Literature DB >> 31751453

Evaluation of a Single-Dose Nucleoside-Modified Messenger RNA Vaccine Encoding Hendra Virus-Soluble Glycoprotein Against Lethal Nipah virus Challenge in Syrian Hamsters.

Michael K Lo1, Jessica R Spengler1, Stephen R Welch1, Jessica R Harmon1, JoAnn D Coleman-McCray1, Florine E M Scholte1, Punya Shrivastava-Ranjan1, Joel M Montgomery1, Stuart T Nichol1, Drew Weissman2, Christina F Spiropoulou1.   

Abstract

In the absence of approved vaccines and therapeutics for use in humans, Nipah virus (NiV) continues to cause fatal outbreaks of encephalitis and respiratory disease in Bangladesh and India on a near-annual basis. We determined that a single dose of a lipid nanoparticle nucleoside-modified messenger RNA vaccine encoding the soluble Hendra virus glycoprotein protected up to 70% of Syrian hamsters from lethal NiV challenge, despite animals having suboptimally primed immune responses before challenge. These data provide a foundation from which to optimize future messenger RNA vaccination studies against NiV and other highly pathogenic viruses. Published by Oxford University Press for the Infectious Diseases Society of America 2019.

Entities:  

Keywords:  Nipah virus; CNS; Syrian hamster; brain; disease; hemorrhagic fever; lung; mRNA vaccine; neurological; respiratory; soluble Hendra virus glycoprotein; virus

Mesh：

Substances：

Year:  2020        PMID： 31751453      PMCID： PMC7368163          DOI： 10.1093/infdis/jiz553

Source DB:  PubMed          Journal:  J Infect Dis        ISSN： 0022-1899            Impact factor:   5.226


  14 in total

1.  Nipah Virus Outbreaks: Still Small but Extremely Lethal.

Authors:  Christina F Spiropoulou
Journal:  J Infect Dis       Date:  2019-05-24       Impact factor: 5.226

2.  HPLC purification of in vitro transcribed long RNA.

Authors:  Drew Weissman; Norbert Pardi; Hiro Muramatsu; Katalin Karikó
Journal:  Methods Mol Biol       Date:  2013

Review 3.  mRNA vaccines - a new era in vaccinology.

Authors:  Norbert Pardi; Michael J Hogan; Frederick W Porter; Drew Weissman
Journal:  Nat Rev Drug Discov       Date:  2018-01-12       Impact factor: 84.694

4.  Modified mRNA-Based Vaccines Elicit Robust Immune Responses and Protect Guinea Pigs From Ebola Virus Disease.

Authors:  Michelle Meyer; Eric Huang; Olga Yuzhakov; Palaniappan Ramanathan; Giuseppe Ciaramella; Alexander Bukreyev
Journal:  J Infect Dis       Date:  2018-01-17       Impact factor: 5.226

5.  Single-dose live-attenuated vesicular stomatitis virus-based vaccine protects African green monkeys from Nipah virus disease.

Authors:  Joseph Prescott; Blair L DeBuysscher; Friederike Feldmann; Donald J Gardner; Elaine Haddock; Cynthia Martellaro; Dana Scott; Heinz Feldmann
Journal:  Vaccine       Date:  2015-04-10       Impact factor: 3.641

6.  Single-dose replication-defective VSV-based Nipah virus vaccines provide protection from lethal challenge in Syrian hamsters.

Authors:  Michael K Lo; Brian H Bird; Anasuya Chattopadhyay; Clifton P Drew; Brock E Martin; Joann D Coleman; John K Rose; Stuart T Nichol; Christina F Spiropoulou
Journal:  Antiviral Res       Date:  2013-10-30       Impact factor: 5.970

7.  Zika virus protection by a single low-dose nucleoside-modified mRNA vaccination.

Authors:  Norbert Pardi; Michael J Hogan; Rebecca S Pelc; Hiromi Muramatsu; Hanne Andersen; Christina R DeMaso; Kimberly A Dowd; Laura L Sutherland; Richard M Scearce; Robert Parks; Wendeline Wagner; Alex Granados; Jack Greenhouse; Michelle Walker; Elinor Willis; Jae-Sung Yu; Charles E McGee; Gregory D Sempowski; Barbara L Mui; Ying K Tam; Yan-Jang Huang; Dana Vanlandingham; Veronica M Holmes; Harikrishnan Balachandran; Sujata Sahu; Michelle Lifton; Stephen Higgs; Scott E Hensley; Thomas D Madden; Michael J Hope; Katalin Karikó; Sampa Santra; Barney S Graham; Mark G Lewis; Theodore C Pierson; Barton F Haynes; Drew Weissman
Journal:  Nature       Date:  2017-02-02       Impact factor: 49.962

8.  Nucleoside-modified mRNA vaccines induce potent T follicular helper and germinal center B cell responses.

Authors:  Norbert Pardi; Michael J Hogan; Martin S Naradikian; Kaela Parkhouse; Derek W Cain; Letitia Jones; M Anthony Moody; Hans P Verkerke; Arpita Myles; Elinor Willis; Celia C LaBranche; David C Montefiori; Jenna L Lobby; Kevin O Saunders; Hua-Xin Liao; Bette T Korber; Laura L Sutherland; Richard M Scearce; Peter T Hraber; István Tombácz; Hiromi Muramatsu; Houping Ni; Daniel A Balikov; Charles Li; Barbara L Mui; Ying K Tam; Florian Krammer; Katalin Karikó; Patricia Polacino; Laurence C Eisenlohr; Thomas D Madden; Michael J Hope; Mark G Lewis; Kelly K Lee; Shiu-Lok Hu; Scott E Hensley; Michael P Cancro; Barton F Haynes; Drew Weissman
Journal:  J Exp Med       Date:  2018-05-08       Impact factor: 17.579

9.  An antibody against the F glycoprotein inhibits Nipah and Hendra virus infections.

Authors:  Ha V Dang; Yee-Peng Chan; Young-Jun Park; Joost Snijder; Sofia Cheliout Da Silva; Bang Vu; Lianying Yan; Yan-Ru Feng; Barry Rockx; Thomas W Geisbert; Chad E Mire; Christopher C Broder; David Veesler
Journal:  Nat Struct Mol Biol       Date:  2019-09-30       Impact factor: 15.369

10.  Vaccination of ferrets with a recombinant G glycoprotein subunit vaccine provides protection against Nipah virus disease for over 12 months.

Authors:  Jackie A Pallister; Reuben Klein; Rachel Arkinstall; Jessica Haining; Fenella Long; John R White; Jean Payne; Yan-Ru Feng; Lin-Fa Wang; Christopher C Broder; Deborah Middleton
Journal:  Virol J       Date:  2013-07-16       Impact factor: 4.099
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  13 in total

1.  Alterations in Blood Chemistry Levels Associated With Nipah Virus Disease in the Syrian Hamster Model.

Authors:  Sarah C Genzer; Stephen R Welch; Florine E M Scholte; Jessica R Harmon; JoAnn D Coleman-McCray; Michael K Lo; Joel M Montgomery; Stuart T Nichol; Christina F Spiropoulou; Jessica R Spengler
Journal:  J Infect Dis       Date:  2020-05-11       Impact factor: 5.226

Review 2.  mRNA vaccines: Past, present, future.

Authors:  Mia Karam; Georges Daoud
Journal:  Asian J Pharm Sci       Date:  2022-06-30       Impact factor: 9.273

Review 3.  mRNA-based therapeutics: powerful and versatile tools to combat diseases.

Authors:  Shugang Qin; Xiaoshan Tang; Yuting Chen; Kepan Chen; Na Fan; Wen Xiao; Qian Zheng; Guohong Li; Yuqing Teng; Min Wu; Xiangrong Song
Journal:  Signal Transduct Target Ther       Date:  2022-05-21

Review 4.  The Immunobiology of Nipah Virus.

Authors:  Yvonne Jing Mei Liew; Puteri Ainaa S Ibrahim; Hui Ming Ong; Chee Ning Chong; Chong Tin Tan; Jie Ping Schee; Raúl Gómez Román; Neil George Cherian; Won Fen Wong; Li-Yen Chang
Journal:  Microorganisms       Date:  2022-06-06

Review 5.  The legacy of mRNA engineering: A lineup of pioneers for the Nobel Prize.

Authors:  Miroslaw Janowski; Anna Andrzejewska
Journal:  Mol Ther Nucleic Acids       Date:  2022-07-13       Impact factor: 10.183

Review 6.  RNA Vaccines: A Suitable Platform for Tackling Emerging Pandemics?

Authors:  Jonas B Sandbrink; Robin J Shattock
Journal:  Front Immunol       Date:  2020-12-22       Impact factor: 7.561

Review 7.  Evolution of Nipah Virus Infection: Past, Present, and Future Considerations.

Authors:  Naomi Hauser; Alexis C Gushiken; Shivakumar Narayanan; Shyam Kottilil; Joel V Chua
Journal:  Trop Med Infect Dis       Date:  2021-02-14

8.  Lipid nanoparticle encapsulated nucleoside-modified mRNA vaccines elicit polyfunctional HIV-1 antibodies comparable to proteins in nonhuman primates.

Authors:  Kevin O Saunders; Norbert Pardi; Robert Parks; Sampa Santra; Zekun Mu; Laura Sutherland; Richard Scearce; Maggie Barr; Amanda Eaton; Giovanna Hernandez; Derrick Goodman; Michael J Hogan; Istvan Tombacz; David N Gordon; R Wes Rountree; Yunfei Wang; Mark G Lewis; Theodore C Pierson; Chris Barbosa; Ying Tam; Xiaoying Shen; Guido Ferrari; Georgia D Tomaras; David C Montefiori; Drew Weissman; Barton F Haynes
Journal:  NPJ Vaccines       Date:  2021-04-09       Impact factor: 7.344

Review 9.  Medical countermeasures against henipaviruses: a review and public health perspective.

Authors:  Raúl Gómez Román; Nadia Tornieporth; Neil George Cherian; Amy C Shurtleff; Maïna L'Azou Jackson; Debra Yeskey; Adam Hacker; Eric Mungai; Tung Thanh Le
Journal:  Lancet Infect Dis       Date:  2021-11-01       Impact factor: 25.071

10.  Vaccines to Emerging Viruses: Nipah and Hendra.

Authors:  Moushimi Amaya; Christopher C Broder
Journal:  Annu Rev Virol       Date:  2020-09-29       Impact factor: 10.431
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