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Literature DB >> 31747016

Alterations in Blood Chemistry Levels Associated With Nipah Virus Disease in the Syrian Hamster Model.

Sarah C Genzer¹, Stephen R Welch², Florine E M Scholte², Jessica R Harmon², JoAnn D Coleman-McCray², Michael K Lo², Joel M Montgomery², Stuart T Nichol², Christina F Spiropoulou², Jessica R Spengler².

Abstract

Nipah virus (NiV; family Paramyxoviridae, genus Henipavirus) infection can cause severe respiratory and neurological disease in humans. The pathophysiology of disease is not fully understood, and it may vary by presentation and clinical course. In this study, we investigate changes in blood chemistry in NiV-infected Syrian hamsters that survived or succumbed to disease. Increased sodium and magnesium and decreased albumin and lactate levels were detected in animals euthanized with severe clinical disease compared with mock-infected controls. When subjects were grouped by clinical syndrome, additional trends were discernable, highlighting changes associated with either respiratory or neurological disease. Published by Oxford University Press for the Infectious Diseases Society of America 2019.

Entities: Chemical Disease Gene Species

Keywords: Nipah virus; Syrian hamster; blood; neurological; respiratory

Mesh：

Substances：

Year: 2020 PMID： 31747016 PMCID： PMC7368165 DOI： 10.1093/infdis/jiz552

Source DB: PubMed Journal: J Infect Dis ISSN： 0022-1899 Impact factor: 5.226

14 in total

1. Nipah virus infection: pathology and pathogenesis of an emerging paramyxoviral zoonosis.

Authors: Kum Thong Wong; Wun-Ju Shieh; Shalini Kumar; Karim Norain; Wahidah Abdullah; Jeannette Guarner; Cynthia S Goldsmith; Kaw Bing Chua; Sai Kit Lam; Chong Tin Tan; Khean Jin Goh; Heng Thay Chong; Rani Jusoh; Pierre E Rollin; Thomas G Ksiazek; Sherif R Zaki
Journal: Am J Pathol Date: 2002-12 Impact factor: 4.307

2. Late clinical and magnetic resonance imaging follow up of Nipah virus infection.

Authors: C C T Lim; W L Lee; Y S Leo; K E Lee; K P Chan; A E Ling; H Oh; A P Auchus; N I Paton; F Hui; P A Tambyah
Journal: J Neurol Neurosurg Psychiatry Date: 2003-01 Impact factor: 10.154

Review 3. Nipah virus disease: A rare and intractable disease.

Authors: Sayantan Banerjee; Nitin Gupta; Parul Kodan; Ankit Mittal; Yogiraj Ray; Neeraj Nischal; Manish Soneja; Ashutosh Biswas; Naveet Wig
Journal: Intractable Rare Dis Res Date: 2019-02

4. Late presentation of Nipah virus encephalitis and kinetics of the humoral immune response.

Authors: S C Wong; M H Ooi; M N Wong; P H Tio; T Solomon; M J Cardosa
Journal: J Neurol Neurosurg Psychiatry Date: 2001-10 Impact factor: 10.154

5. Clinical features of Nipah virus encephalitis among pig farmers in Malaysia.

Authors: K J Goh; C T Tan; N K Chew; P S Tan; A Kamarulzaman; S A Sarji; K T Wong; B J Abdullah; K B Chua; S K Lam
Journal: N Engl J Med Date: 2000-04-27 Impact factor: 91.245

6. Clinical outcome of henipavirus infection in hamsters is determined by the route and dose of infection.

Authors: Barry Rockx; Douglas Brining; Joshua Kramer; Julie Callison; Hideki Ebihara; Keith Mansfield; Heinz Feldmann
Journal: J Virol Date: 2011-05-18 Impact factor: 5.103

7. Therapeutic treatment of Nipah virus infection in nonhuman primates with a neutralizing human monoclonal antibody.

Authors: Thomas W Geisbert; Chad E Mire; Joan B Geisbert; Yee-Peng Chan; Krystle N Agans; Friederike Feldmann; Karla A Fenton; Zhongyu Zhu; Dimiter S Dimitrov; Dana P Scott; Katharine N Bossart; Heinz Feldmann; Christopher C Broder
Journal: Sci Transl Med Date: 2014-06-25 Impact factor: 17.956

8. Evaluation of a Single-Dose Nucleoside-Modified Messenger RNA Vaccine Encoding Hendra Virus-Soluble Glycoprotein Against Lethal Nipah virus Challenge in Syrian Hamsters.

Authors: Michael K Lo; Jessica R Spengler; Stephen R Welch; Jessica R Harmon; JoAnn D Coleman-McCray; Florine E M Scholte; Punya Shrivastava-Ranjan; Joel M Montgomery; Stuart T Nichol; Drew Weissman; Christina F Spiropoulou
Journal: J Infect Dis Date: 2020-05-11 Impact factor: 5.226

Alterations in Blood Chemistry Levels Associated With Nipah Virus Disease in the Syrian Hamster Model.

1. Nipah virus infection: pathology and pathogenesis of an emerging paramyxoviral zoonosis.

2. Late clinical and magnetic resonance imaging follow up of Nipah virus infection.

Review 3. Nipah virus disease: A rare and intractable disease.

4. Late presentation of Nipah virus encephalitis and kinetics of the humoral immune response.

5. Clinical features of Nipah virus encephalitis among pig farmers in Malaysia.

6. Clinical outcome of henipavirus infection in hamsters is determined by the route and dose of infection.

7. Therapeutic treatment of Nipah virus infection in nonhuman primates with a neutralizing human monoclonal antibody.

8. Evaluation of a Single-Dose Nucleoside-Modified Messenger RNA Vaccine Encoding Hendra Virus-Soluble Glycoprotein Against Lethal Nipah virus Challenge in Syrian Hamsters.

9. In Situ Imaging of Fluorescent Nipah Virus Respiratory and Neurological Tissue Tropism in the Syrian Hamster Model.

10. Suboptimal Handling of Piccolo Samples or Reagent Discs for Consideration in Ebola Response.

1. Dynamic Changes of the Blood Chemistry in Syrian Hamsters Post-Acute COVID-19.

Review 2. Drivers and Distribution of Henipavirus-Induced Syncytia: What Do We Know?