Malon Van den Hof1, Anne Marleen Ter Haar1, Matthan W A Caan1, Rene Spijker1, Johanna H van der Lee1, Dasja Pajkrt1. 1. Emma Children's Hospital (MVH, AMtH, DP), Amsterdam University Medical Center, location Academic Medical Center, University of Amsterdam, Pediatric Infectious Diseases, Amsterdam, the Netherlands; Biomedical Engineering and Physics (MWAC), Amsterdam University Medical Center, location Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands; Medical Library (RS), Amsterdam University Medical Center, location Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands; Cochrane Netherlands (RS), Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, the Netherlands; and Emma Children's Hospital (JHL), Amsterdam University Medical Centers, location Academic Medical Center, University of Amsterdam, Pediatric Clinical Research Office, Amsterdam, the Netherlands.
Abstract
OBJECTIVE: We aim to give an overview of the available evidence on brain structure and function in PHIV-infected patients (PHIV+) using long-term combination antiretroviral therapy (cART) and how differences change over time. METHODS: We conducted an electronic search using MEDLINE, Embase, and PsycINFO. We used the following selection criteria: cohort and cross-sectional studies that reported on brain imaging differences between PHIV+ of all ages who used cART for at least six months before neuroimaging and HIV-negative controls. Two reviewers independently selected studies, performed data extraction, and assessed quality of studies. RESULTS: After screening 1500 abstracts and 343 full-text articles, we identified 19 eligible articles. All included studies had a cross-sectional design and used MRI with different modalities: structural MRI (n = 7), diffusion tensor imaging (DTI) (n = 6), magnetic resonance spectroscopy (n = 5), arterial spin labeling (n = 1), and resting-state functional neuroimaging (n = 1). Studies showed considerable methodological limitations and heterogeneity, preventing us to perform meta-analyses. DTI data on white matter microstructure suggested poorer directional diffusion in cART-treated PHIV+ compared with controls. Other modalities were inconclusive. CONCLUSION: Evidence may suggest brain structure and function differences in the population of PHIV+ on long-term cART compared with the HIV-negative population. Because of a small study population, and considerable heterogeneity and methodological limitations, the extent of brain structure and function differences on neuroimaging between groups remains unknown.
OBJECTIVE: We aim to give an overview of the available evidence on brain structure and function in PHIV-infected patients (PHIV+) using long-term combination antiretroviral therapy (cART) and how differences change over time. METHODS: We conducted an electronic search using MEDLINE, Embase, and PsycINFO. We used the following selection criteria: cohort and cross-sectional studies that reported on brain imaging differences between PHIV+ of all ages who used cART for at least six months before neuroimaging and HIV-negative controls. Two reviewers independently selected studies, performed data extraction, and assessed quality of studies. RESULTS: After screening 1500 abstracts and 343 full-text articles, we identified 19 eligible articles. All included studies had a cross-sectional design and used MRI with different modalities: structural MRI (n = 7), diffusion tensor imaging (DTI) (n = 6), magnetic resonance spectroscopy (n = 5), arterial spin labeling (n = 1), and resting-state functional neuroimaging (n = 1). Studies showed considerable methodological limitations and heterogeneity, preventing us to perform meta-analyses. DTI data on white matter microstructure suggested poorer directional diffusion in cART-treated PHIV+ compared with controls. Other modalities were inconclusive. CONCLUSION: Evidence may suggest brain structure and function differences in the population of PHIV+ on long-term cART compared with the HIV-negative population. Because of a small study population, and considerable heterogeneity and methodological limitations, the extent of brain structure and function differences on neuroimaging between groups remains unknown.
Authors: C Paula Lewis-de Los Angeles; Kathryn I Alpert; Paige L Williams; Kathleen Malee; Yanling Huo; John G Csernansky; Ram Yogev; Russell B Van Dyke; Elizabeth R Sowell; Lei Wang Journal: J Pediatric Infect Dis Soc Date: 2016-12 Impact factor: 3.164
Authors: Jacqueline Hoare; Jean-Paul Fouche; Nicole Phillips; John A Joska; Robert Paul; Kirsten A Donald; Kevin G F Thomas; Dan J Stein Journal: AIDS Date: 2015-09-10 Impact factor: 4.177
Authors: Kristina A Uban; Megan M Herting; Paige L Williams; Tanvi Ajmera; Prapti Gautam; Yanling Huo; Kathleen M Malee; Ram Yogev; John G Csernansky; Lei Wang; Sharon L Nichols; Elizabeth R Sowell Journal: AIDS Date: 2015-06-01 Impact factor: 4.177
Authors: C Ackermann; S Andronikou; M G Saleh; B Laughton; A A Alhamud; A van der Kouwe; M Kidd; M F Cotton; E M Meintjes Journal: AJNR Am J Neuroradiol Date: 2016-08-18 Impact factor: 3.825
Authors: R Nagarajan; M K Sarma; M A Thomas; L Chang; U Natha; M Wright; J Hayes; K Nielsen-Saines; D E Michalik; J Deville; J A Church; K Mason; T Critton-Mastandrea; S Nazarian; J Jing; M A Keller Journal: J Neuroimmune Pharmacol Date: 2012-10-13 Impact factor: 4.147
Authors: M A Keller; T N Venkatraman; A Thomas; A Deveikis; C LoPresti; J Hayes; N Berman; I Walot; S Padilla; J Johnston-Jones; T Ernst; L Chang Journal: Neurology Date: 2004-05-25 Impact factor: 9.910
Authors: Sophie Cohen; Matthan W A Caan; Henk-Jan Mutsaerts; Henriette J Scherpbier; Taco W Kuijpers; Peter Reiss; Charles B L M Majoie; Dasja Pajkrt Journal: Neurology Date: 2015-11-11 Impact factor: 9.910
Authors: Jason G van Genderen; Cecilia Chia; Malon Van den Hof; Henk J M M Mutsaerts; Liesbeth Reneman; Dasja Pajkrt; Anouk Schrantee Journal: Neurology Date: 2022-08-08 Impact factor: 11.800
Authors: Julie van der Post; Jason G van Genderen; Johannes A Heijst; Charlotte Blokhuis; Charlotte E Teunissen; Dasja Pajkrt Journal: Viruses Date: 2022-03-24 Impact factor: 5.818
Authors: Malon Van den Hof; Pien E J Jellema; Anne Marleen Ter Haar; Henriette J Scherpbier; Anouk Schrantee; Antonia Kaiser; Matthan W A Caan; Charles B L M Majoie; Peter Reiss; Ferdinand W N M Wit; Henk-Jan M M Mutsaerts; Dasja Pajkrt Journal: AIDS Date: 2021-07-01 Impact factor: 4.632
Authors: Noëlle van Biljon; Frances Robertson; Martha Holmes; Mark F Cotton; Barbara Laughton; Andre van der Kouwe; Ernesta Meintjes; Francesca Little Journal: Neuroimage Date: 2021-05-04 Impact factor: 6.556
Authors: C Paula Lewis-de Los Angeles; Paige L Williams; Lisanne M Jenkins; Yanling Huo; Kathleen Malee; Kathryn I Alpert; Kristina A Uban; Megan M Herting; John G Csernansky; Sharon L Nichols; Russell B Van Dyke; Elizabeth R Sowell; Lei Wang Journal: Neuroimage Clin Date: 2020-03-16 Impact factor: 4.881
Authors: Jason G van Genderen; Malon Van den Hof; Anne Marleen Ter Haar; Charlotte Blokhuis; Vera C Keil; Dasja Pajkrt; Henk J M M Mutsaerts Journal: Viruses Date: 2021-10-28 Impact factor: 5.048