| Literature DB >> 31748707 |
Richard J Weaver1, Eric A Blomme2, Amy E Chadwick3, Ian M Copple3, Helga H J Gerets4, Christopher E Goldring3, Andre Guillouzo5, Philip G Hewitt6, Magnus Ingelman-Sundberg7, Klaus Gjervig Jensen8, Satu Juhila9, Ursula Klingmüller10, Gilles Labbe11, Michael J Liguori2, Cerys A Lovatt12, Paul Morgan13, Dean J Naisbitt3, Raymond H H Pieters14, Jan Snoeys15, Bob van de Water16, Dominic P Williams13, B Kevin Park17.
Abstract
Drug-induced liver injury (DILI) is a patient-specific, temporal, multifactorial pathophysiological process that cannot yet be recapitulated in a single in vitro model. Current preclinical testing regimes for the detection of human DILI thus remain inadequate. A systematic and concerted research effort is required to address the deficiencies in current models and to present a defined approach towards the development of new or adapted model systems for DILI prediction. This Perspective defines the current status of available models and the mechanistic understanding of DILI, and proposes our vision of a roadmap for the development of predictive preclinical models of human DILI.Entities:
Mesh：
Year: 2019 PMID： 31748707 DOI： 10.1038/s41573-019-0048-x
Source DB: PubMed Journal: Nat Rev Drug Discov ISSN： 1474-1776 Impact factor: 84.694