| Literature DB >> 31748690 |
Gerome Breen1,2, Thalia C Eley3,4, Kirstin L Purves5, Jonathan R I Coleman5,6, Sandra M Meier7,8,9, Christopher Rayner5, Katrina A S Davis6,10, Rosa Cheesman5, Marie Bækvad-Hansen9,11, Anders D Børglum9,12,13, Shing Wan Cho5, J Jürgen Deckert14, Héléna A Gaspar5,6, Jonas Bybjerg-Grauholm9,11, John M Hettema15, Matthew Hotopf6,10, David Hougaard9,11, Christopher Hübel5,6,16, Carol Kan17, Andrew M McIntosh18,19, Ole Mors8,9, Preben Bo Mortensen9,13,20, Merete Nordentoft9,21, Thomas Werge9,22,23, Kristin K Nicodemus24, Manuel Mattheisen9,12,14,25.
Abstract
Anxiety disorders are common, complex psychiatric disorders with twin heritabilities of 30-60%. We conducted a genome-wide association study of Lifetime Anxiety Disorder (ncase = 25 453, ncontrol = 58 113) and an additional analysis of Current Anxiety Symptoms (ncase = 19 012, ncontrol = 58 113). The liability scale common variant heritability estimate for Lifetime Anxiety Disorder was 26%, and for Current Anxiety Symptoms was 31%. Five novel genome-wide significant loci were identified including an intergenic region on chromosome 9 that has previously been associated with neuroticism, and a locus overlapping the BDNF receptor gene, NTRK2. Anxiety showed significant positive genetic correlations with depression and insomnia as well as coronary artery disease, mirroring findings from epidemiological studies. We conclude that common genetic variation accounts for a substantive proportion of the genetic architecture underlying anxiety.Entities:
Mesh：
Year: 2019 PMID： 31748690 PMCID： PMC7237282 DOI： 10.1038/s41380-019-0559-1
Source DB: PubMed Journal: Mol Psychiatry ISSN： 1359-4184 Impact factor: 15.992