Literature DB >> 31745968

Overexpression of EIF5A2 is associated with poor survival and aggressive tumor biology in gallbladder cancer.

Xin Zheng1,2, Lei Gao1,3, Bo-Tao Wang1,3, Ping Shen1,3, Xiang-Fei Yuan1, Lan-Qiu Zhang1, Lei Yang1, Da-Peng Zhang1, Qi Zhang4, Xi-Mo Wang3,5.   

Abstract

Gallbladder cancer (GBC) is a malignant tumor of the biliary tract. The main problem affecting the treatment of gallbladder cancer is late diagnosis and poor prognosis. EIF5A2 is one of two isoforms of the EIF5A family and is reported to be a new oncogenic protein in many human cancers. In this study, our results showed for the first time that EIF5A2 was overexpressed in GBC samples compared with non-tumor tissue. Overexpression of EIF5A2 was associated with lymph node metastasis, tumor differentiation, UICC (Union for International Cancer Control) staging, histological type, metastasis, and tumor size. Overexpression of EIF5A2 in gallbladder carcinoma tissues is also associated with poor prognosis in patients. The interference of EIF5A2 significantly inhibited the proliferation, cell cycle, migration and colony formation of GBC-SD cells in vitro. Our results suggest that EIF5A2 is a target oncogene and may be an important prognostic biomarker in the pathogenesis of gallbladder cancer.

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Year:  2019        PMID： 31745968     DOI： 10.14670/HH-18-186

Source DB:  PubMed          Journal:  Histol Histopathol        ISSN： 0213-3911            Impact factor:   2.303


  28 in total

1.  Recurrent chromosome changes in 62 primary gastric carcinomas detected by comparative genomic hybridization.

Authors:  X Y Guan; S B Fu; J C Xia; Y Fang; J S Sham; B D Du; H Zhou; S Lu; B Q Wang; Y Z Lin; Q Liang; X M Li; B Du; X M Ning; J R Du; P Li; J M Trent
Journal:  Cancer Genet Cytogenet       Date:  2000-11

2.  Isolation of a novel candidate oncogene within a frequently amplified region at 3q26 in ovarian cancer.

Authors:  X Y Guan; J S Sham; T C Tang; Y Fang; K K Huo; J M Yang
Journal:  Cancer Res       Date:  2001-05-01       Impact factor: 12.701

Review 3.  Molecular cytogenetic characterization of pancreas cancer cell lines reveals high complexity chromosomal alterations.

Authors:  C A Griffin; L Morsberger; A L Hawkins; M Haddadin; A Patel; T Ried; E Schrock; E J Perlman; E Jaffee
Journal:  Cytogenet Genome Res       Date:  2007       Impact factor: 1.636

Review 4.  eIF5A isoforms and cancer: two brothers for two functions?

Authors:  M Caraglia; M H Park; E C Wolff; M Marra; A Abbruzzese
Journal:  Amino Acids       Date:  2011-12-03       Impact factor: 3.520

5.  Overexpression of eIF5A-2 is an adverse prognostic marker of survival in stage I non-small cell lung cancer patients.

Authors:  Li-Ru He; Hong-Yun Zhao; Bin-Kui Li; Yan-Hui Liu; Meng-Zhong Liu; Xin-Yuan Guan; Xiu-Wu Bian; Yi-Xin Zeng; Dan Xie
Journal:  Int J Cancer       Date:  2011-07-01       Impact factor: 7.396

6.  Comparative genomic hybridization analysis of 38 breast cancer cell lines: a basis for interpreting complementary DNA microarray data.

Authors:  F Forozan; E H Mahlamäki; O Monni; Y Chen; R Veldman; Y Jiang; G C Gooden; S P Ethier; A Kallioniemi; O P Kallioniemi
Journal:  Cancer Res       Date:  2000-08-15       Impact factor: 12.701

7.  Geographic variation of gallbladder cancer mortality and risk factors in Chile: a population-based ecologic study.

Authors:  Marcelo E Andia; Ann W Hsing; Gabriella Andreotti; Catterina Ferreccio
Journal:  Int J Cancer       Date:  2008-09-15       Impact factor: 7.396

8.  Recurrent genetic alterations in 26 colorectal carcinomas and 21 adenomas from Chinese patients.

Authors:  Qiao-Jie He; Wei-Fen Zeng; Jonathan S T Sham; Dan Xie; Xing-Wu Yang; Han-Liang Lin; Wen-Hua Zhan; Feng Lin; Sui-De Zeng; Daping Nie; Lin-Fei Ma; Chu-Jun Li; Shen Lu; Xin-Yuan Guan
Journal:  Cancer Genet Cytogenet       Date:  2003-07-15

9.  Overexpression of EIF-5A2 is an independent predictor of outcome in patients of urothelial carcinoma of the bladder treated with radical cystectomy.

Authors:  Wei Chen; Jun-Hang Luo; Wen-Feng Hua; Fang-Jian Zhou; Marie C Lin; Hsiang-Fu Kung; Yi-Xin Zeng; Xin-Yuan Guan; Dan Xie
Journal:  Cancer Epidemiol Biomarkers Prev       Date:  2009-01-20       Impact factor: 4.254

10.  Combined use of AFP, CEA, CA125 and CAl9-9 improves the sensitivity for the diagnosis of gastric cancer.

Authors:  Chao-Zhu He; Kun-He Zhang; Qing Li; Xiao-Hua Liu; Yan Hong; Nong-Hua Lv
Journal:  BMC Gastroenterol       Date:  2013-05-14       Impact factor: 3.067
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  6 in total

1.  Targeting eIF5A2 inhibits prostate carcinogenesis, migration, invasion and metastasis in vitro and in vivo.

Authors:  Xiulong Zhong; Hong Xiu; Yanan Bi; Hongmei Zhang; Laizhen Chang; Huifeng Diao
Journal:  Bioengineered       Date:  2020-01-01       Impact factor: 3.269

2.  Overexpression of lncRNA IRAIN restrains the progression and Temozolomide resistance of glioma via repressing IGF-1R-PI3K-NF-κB signaling pathway.

Authors:  Aishun Guo; Guixia Fang; Zhenrong Lin; Shuishun Zheng; Zhijun Zhuang; Ruisheng Lin; Yanling Lin
Journal:  Histol Histopathol       Date:  2022-02-01       Impact factor: 2.130

3.  Knockdown of eukaryotic translation initiation factor 5A2 enhances the therapeutic efficiency of doxorubicin in hepatocellular carcinoma cells by triggering lethal autophagy.

Authors:  Yuexiao Tang; Ke Chen; Xiaorui Luan; Jinyan Zhang; Rongrong Liu; Xiaoxiao Zheng; Shangzhi Xie; Haiping Ke; Xianning Zhang; Wei Chen
Journal:  Int J Oncol       Date:  2020-11-02       Impact factor: 5.650

4.  EIF5A2 Is Highly Expressed in Anaplastic Thyroid Carcinoma and Is Associated With Tumor Growth by Modulating TGF- Signals.

Authors:  Fengyun Hao; Qingli Zhu; Lingwei Lu; Shukai Sun; Yichuan Huang; Jinna Zhang; Zhaohui Liu; Yuanqing Miao; Xuelong Jiao; Dong Chen
Journal:  Oncol Res       Date:  2020-03-05       Impact factor: 5.574

5.  EIF5A2 controls ovarian tumor growth and metastasis by promoting epithelial to mesenchymal transition via the TGFβ pathway.

Authors:  Guannan Zhao; Wenjing Zhang; Peixin Dong; Hidemichi Watari; Yuqi Guo; Lawrence M Pfeffer; Gabor Tigyi; Junming Yue
Journal:  Cell Biosci       Date:  2021-04-07       Impact factor: 7.133

6.  Prognostic Nomograms to Predict Survival of Patients with Resectable Gallbladder Cancer: A Surveillance, Epidemiology, and End Results (SEER)-Based Analysis.

Authors:  Yan Lin; Hua Chen; Fan Pan
Journal:  Med Sci Monit       Date:  2021-03-30
  6 in total

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