| Literature DB >> 31743875 |
Jiaowen Xu1, Yuanyuan Tu2, Ying Wang3, Xun Xu4, Xiaodong Sun4, Laiqing Xie1, Qingliang Zhao2, Yang Guo1, Yonghui Gu5, Jingxia Du1, Shu Du2, Manhui Zhu6, E Song7.
Abstract
Age-related macular degeneration (AMD) is a leading cause of vision loss in the elderly and is attributed to choroidal neovascularization (CNV), which is a feature of wet AMD. The hypoxia-inducible factor-1α (HIF-1α)/vascular endothelial growth factor (VEGF)/VEGF receptor 2 (VEGFR2) pathway contributes to the pathogenesis of CNV. M1-type macrophages/microglia secrete interleukin-6 (IL-6) and tumor necrosis factor α (TNF-α), facilitating the development of CNV. Epigallocatechin-3-gallate (EGCG) is a kind of polyphenol in green tea that exerts anti-inflammatory and antiangiogenic effects. In this study, a prodrug of EGCG (pro-EGCG) alleviated mouse laser-induced CNV leakage and reduced CNV area by down-regulating HIF-1α/VEGF/VEGFR2 pathway; M1-type macrophage/microglia polarization; as well as endothelial cell viability, proliferation, migration and tube formation, indicating a novel potential therapy for AMD.Entities:
Keywords: Age-related macular degeneration (AMD); Choroidal neovascularization (CNV); HIF-1α/VEGF/VEGFR2 pathway; M1-type macrophages/microglia; Prodrug of epigallocatechin-3-gallate (pro-EGCG)
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Year: 2019 PMID： 31743875 DOI： 10.1016/j.biopha.2019.109606
Source DB: PubMed Journal: Biomed Pharmacother ISSN： 0753-3322 Impact factor: 6.529