Sijing Xia1, Qin Chen1, Bing Niu1.
Abstract
BACKGROUND: CD28, a cell surface glycoprotein receptor, predominantly expressed on activated T cells, belongs to the Ig superfamily and provides a critical co-stimulatory signal. CTLA-4 has sequence homology to CD28, and is expressed on T cells after activation. It provides an inhibition signal coordinated with CD28 to regulate T cell activation. Both of them regulate T cell proliferation and differentiation and play an important role in the immune response pathway in vivo.
OBJECTIVE: We studied the special role of different structural sites of CD28 in producing costimulatory signals.
METHODS: We reviewed the relevant literature, mainly regarding the structure of CD28 to clarify its biological function, and its role in the immune response.
RESULTS: In recent years, increasingly attention has been paid to CD28, which is considered as a key therapeutic target for many modern diseases, especially some immune diseases.
CONCLUSION: In this paper, we mainly introduce the structure of CD28 and its related biological functions, as well as the application of costimulatory pathways targeting CD28 in disease treatment. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.
BACKGROUND: CD28, a cell surface glycoprotein receptor, predominantly expressed on activated T cells, belongs to the Ig superfamily and provides a critical co-stimulatory signal. CTLA-4 has sequence homology to CD28, and is expressed on T cells after activation. It provides an inhibition signal coordinated with CD28 to regulate T cell activation. Both of them regulate T cell proliferation and differentiation and play an important role in the immune response pathway in vivo.
OBJECTIVE: We studied the special role of different structural sites of CD28 in producing costimulatory signals.
METHODS: We reviewed the relevant literature, mainly regarding the structure of CD28 to clarify its biological function, and its role in the immune response.
RESULTS: In recent years, increasingly attention has been paid to CD28, which is considered as a key therapeutic target for many modern diseases, especially some immune diseases.
CONCLUSION: In this paper, we mainly introduce the structure of CD28 and its related biological functions, as well as the application of costimulatory pathways targeting CD28 in disease treatment. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.
Entities:
Keywords:
CD28; CTLA-4; T cell activation; costimulation; human disease; immune-responses; ligand.
Mesh：
Substances：
Year: 2020
PMID： 31729942 DOI： 10.2174/1389450120666191114102830
Source DB: PubMed Journal: Curr Drug Targets ISSN： 1389-4501 Impact factor: 3.465