Literature DB >> 31728384

Lower T cell inhibitory receptor level in mononuclear cells from cord blood compared with peripheral blood.

Ying Lin1, Jinrong Lin2, Jingying Huang3, Youchun Chen3, Jiaxiong Tan4, Yangqiu Li3,4, Shaohua Chen3.   

Abstract

T cell inhibitory receptors play important role in maintaining T cell homeostasis. The feature of such negative costimulator signal transduction pathway in cord blood (CB) T cells remains unclear. In this study, the expression levels of T cell inhibitory receptors including programmed death-1 (PD-1), cytotoxic T lymphocyte antigen-4 (CTLA-4), T cell immunoglobulin mucin-3 (Tim-3), lymphocyte activation gene-3 (LAG-3) and B and T lymphocyte attenuator (BTLA) were characterized in CB and compared with peripheral blood (PB). Significant lower expression of PD-1, CTLA-4, LAG-3 and BTLA was found in CB, while similar expression level of Tim-3 was showed between CB and PB. Together, different expression pattern of such T cell inhibitory receptor in CB is worthy to further discuss their role on immune response when CB is used in cord blood stem cell transplantation as well as allogeneic chimeric antigen receptor T-cell producing. 2019 Stem Cell Investigation. All rights reserved.

Entities:  

Keywords:  Cord blood (CB); T cell; T cell inhibitory receptor; gene expression

Year:  2019        PMID： 31728384      PMCID： PMC6851436          DOI： 10.21037/sci.2019.09.01

Source DB:  PubMed          Journal:  Stem Cell Investig        ISSN： 2306-9759


  24 in total

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4.  Increased exhausted CD8+ T cells with programmed death-1, T-cell immunoglobulin and mucin-domain-containing-3 phenotype in patients with multiple myeloma.

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Journal:  J Hematol Oncol       Date:  2018-03-02       Impact factor: 17.388

6.  Reduced CTLA-4 protein and messenger RNA expression in umbilical cord blood T lymphocytes.

Authors:  Robin E Miller; John D Fayen; Shaden F Mohammad; Kevin Stein; Suzanne Kadereit; Kathleen Daum Woods; R Michael Sramkoski; James W Jacobberger; Dennis Templeton; Susan B Shurin; Mary J Laughlin
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Authors:  Danlin Yao; Ling Xu; Jiaxiong Tan; Yikai Zhang; Shuai Lu; Mingde Li; Sichun Lu; Lijian Yang; Shaohua Chen; Jie Chen; Jing Lai; Yuhong Lu; Xiuli Wu; Xianfeng Zha; Yangqiu Li
Journal:  Oncotarget       Date:  2017-09-16

Review 10.  Recent developments in immunotherapy of acute myeloid leukemia.

Authors:  Felix S Lichtenegger; Christina Krupka; Sascha Haubner; Thomas Köhnke; Marion Subklewe
Journal:  J Hematol Oncol       Date:  2017-07-25       Impact factor: 17.388
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Journal:  Cancers (Basel)       Date:  2022-06-28       Impact factor: 6.575

2.  Homeostatic cytokines tune naivety and stemness of cord blood-derived transgenic T cells.

Authors:  Chrystel Marton; Patricia Mercier-Letondal; Romain Loyon; Olivier Adotévi; Christophe Borg; Jeanne Galaine; Yann Godet
Journal:  Cancer Gene Ther       Date:  2021-10-13       Impact factor: 5.854
  2 in total

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