Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 TTC5 mediates autoregulation of tubulin via mRNA degradation.

Literature DB >> 31727855

TTC5 mediates autoregulation of tubulin via mRNA degradation.

Zhewang Lin¹, Ivana Gasic², Viswanathan Chandrasekaran¹, Niklas Peters¹, Sichen Shao³, Timothy J Mitchison², Ramanujan S Hegde⁴.

Abstract

Tubulins play crucial roles in cell division, intracellular traffic, and cell shape. Tubulin concentration is autoregulated by feedback control of messenger RNA (mRNA) degradation via an unknown mechanism. We identified tetratricopeptide protein 5 (TTC5) as a tubulin-specific ribosome-associating factor that triggers cotranslational degradation of tubulin mRNAs in response to excess soluble tubulin. Structural analysis revealed that TTC5 binds near the ribosome exit tunnel and engages the amino terminus of nascent tubulins. TTC5 mutants incapable of ribosome or nascent tubulin interaction abolished tubulin autoregulation and showed chromosome segregation defects during mitosis. Our findings show how a subset of mRNAs can be targeted for coordinated degradation by a specificity factor that recognizes the nascent polypeptides they encode.

Entities: Chemical

Mesh：

Substances：

Year: 2019 PMID： 31727855 PMCID： PMC6942541 DOI： 10.1126/science.aaz4352

Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728

49 in total

1. UCSF Chimera--a visualization system for exploratory research and analysis.

Authors: Eric F Pettersen; Thomas D Goddard; Conrad C Huang; Gregory S Couch; Daniel M Greenblatt; Elaine C Meng; Thomas E Ferrin
Journal: J Comput Chem Date: 2004-10 Impact factor: 3.376

2. Early Scanning of Nascent Polypeptides inside the Ribosomal Tunnel by NAC.

Authors: Martin Gamerdinger; Kan Kobayashi; Annalena Wallisch; Stefan G Kreft; Carolin Sailer; Renate Schlömer; Nadine Sachs; Ahmad Jomaa; Florian Stengel; Nenad Ban; Elke Deuerling
Journal: Mol Cell Date: 2019-07-31 Impact factor: 17.970

Review 3. Autoregulated instability of tubulin mRNAs: a novel eukaryotic regulatory mechanism.

Authors: D W Cleveland
Journal: Trends Biochem Sci Date: 1988-09 Impact factor: 13.807

4. The p53 cofactor Strap exhibits an unexpected TPR motif and oligonucleotide-binding (OB)-fold structure.

Authors: Cassandra J Adams; Ashley C W Pike; Sandra Maniam; Timothy D Sharpe; Amanda S Coutts; Stefan Knapp; Nicholas B La Thangue; Alex N Bullock
Journal: Proc Natl Acad Sci U S A Date: 2012-02-23 Impact factor: 11.205

5. Autoregulatory control of beta-tubulin mRNA stability is linked to translation elongation.

Authors: D A Gay; S S Sisodia; D W Cleveland
Journal: Proc Natl Acad Sci U S A Date: 1989-08 Impact factor: 11.205

Review 6. The quantification and regulation of microtubule dynamics in the mitotic spindle.

Authors: Juan Jesus Vicente; Linda Wordeman
Journal: Curr Opin Cell Biol Date: 2019-05-17 Impact factor: 8.382

7. A protein complex required for signal-sequence-specific sorting and translocation.

Authors: B Wiedmann; H Sakai; T A Davis; M Wiedmann
Journal: Nature Date: 1994-08-11 Impact factor: 49.962

Review 8. The translation of translational control by FMRP: therapeutic targets for FXS.

Authors: Jennifer C Darnell; Eric Klann
Journal: Nat Neurosci Date: 2013-04-14 Impact factor: 24.884

9. Tools for macromolecular model building and refinement into electron cryo-microscopy reconstructions.

Authors: Alan Brown; Fei Long; Robert A Nicholls; Jaan Toots; Paul Emsley; Garib Murshudov
Journal: Acta Crystallogr D Biol Crystallogr Date: 2015-01-01

10. MolProbity: all-atom structure validation for macromolecular crystallography.

Authors: Vincent B Chen; W Bryan Arendall; Jeffrey J Headd; Daniel A Keedy; Robert M Immormino; Gary J Kapral; Laura W Murray; Jane S Richardson; David C Richardson
Journal: Acta Crystallogr D Biol Crystallogr Date: 2009-12-21

29 in total

1. Protein Synthesis in the Developing Neocortex at Near-Atomic Resolution Reveals Ebp1-Mediated Neuronal Proteostasis at the 60S Tunnel Exit.

Authors: Matthew L Kraushar; Ferdinand Krupp; Dermot Harnett; Paul Turko; Mateusz C Ambrozkiewicz; Thiemo Sprink; Koshi Imami; Manuel Günnigmann; Ulrike Zinnall; Carlos H Vieira-Vieira; Theres Schaub; Agnieszka Münster-Wandowski; Jörg Bürger; Ekaterina Borisova; Hiroshi Yamamoto; Mladen-Roko Rasin; Uwe Ohler; Dieter Beule; Thorsten Mielke; Victor Tarabykin; Markus Landthaler; Günter Kramer; Imre Vida; Matthias Selbach; Christian M T Spahn
Journal: Mol Cell Date: 2020-12-22 Impact factor: 17.970

2. Zn-regulated GTPase metalloprotein activator 1 modulates vertebrate zinc homeostasis.

Authors: Andy Weiss; Caitlin C Murdoch; Katherine A Edmonds; Matthew R Jordan; Andrew J Monteith; Yasiru R Perera; Aslin M Rodríguez Nassif; Amber M Petoletti; William N Beavers; Matthew J Munneke; Sydney L Drury; Evan S Krystofiak; Kishore Thalluri; Hongwei Wu; Angela R S Kruse; Richard D DiMarchi; Richard M Caprioli; Jeffrey M Spraggins; Walter J Chazin; David P Giedroc; Eric P Skaar
Journal: Cell Date: 2022-05-17 Impact factor: 66.850

Review 3. Regulation of Tubulin Gene Expression: From Isotype Identity to Functional Specialization.

Authors: Ivana Gasic
Journal: Front Cell Dev Biol Date: 2022-05-26

4. Mechanism of an intramembrane chaperone for multipass membrane proteins.

Authors: Luka Smalinskaitė; Min Kyung Kim; Aaron J O Lewis; Robert J Keenan; Ramanujan S Hegde
Journal: Nature Date: 2022-10-19 Impact factor: 69.504

5. Ultrasound-targeted microbubble destruction (UTMD)-mediated miR-150-5p attenuates oxygen and glucose deprivation-induced cardiomyocyte injury by inhibiting TTC5 expression.

Authors: Xin Zhong; Yu Chen; Xiangdang Long; Hongtian Chen; Zhaofen Zheng; Hongwei Pan; Jianqiang Peng; Yanfu Liu; Haijun Wang; Yongjun Hu
Journal: Mol Biol Rep Date: 2022-03-31 Impact factor: 2.742