Shuzhen Chen1, Malam Djibo Issa2, Chenghong Wang1, Liang Feng2, Fei Teng2, Bing Li2, Yougui Pan2, Xiaolong Zhang2, Yifei Xu2, Zhuoyu Zhang2, Junhui Su2, Hongxing Ma3, Lingjing Jin4. 1. Department of Nuclear Medicine, Tongji Hospital, Tongji University School of Medicine, No.389 Xincun Road, Putuo District, Shanghai, 200065, China. 2. Department of Neurology, Tongji Hospital, Tongji University School of Medicine, No.389 Xincun Road, Putuo District, Shanghai, 200065, China. 3. Department of Nuclear Medicine, Tongji Hospital, Tongji University School of Medicine, No.389 Xincun Road, Putuo District, Shanghai, 200065, China. 1075828841@qq.com. 4. Department of Neurology, Tongji Hospital, Tongji University School of Medicine, No.389 Xincun Road, Putuo District, Shanghai, 200065, China. lingjingjin@163.com.
Abstract
PURPOSE: This study aimed to evaluate the usefulness of [99mTc]sestamibi ([99mTc]MIBI) single photon emission computed tomography (SPECT)/X-ray computed tomography (CT) imaging for the identification of dystonic muscles in primary cervical dystonia (PCD) patients who underwent botulinum neurotoxin type A (BoNT-A) therapy. PROCEDURES: Thirty-six patients with PCD and 10 healthy subjects (control group) who underwent [99mTc]MIBI SPECT/CT were enrolled. The image characteristics of dystonic muscles and normal muscles were evaluated. Muscle/background ratio (MBR) of six representative muscles was calculated for dystonic muscles in PCD group and normal muscles in control group. In PCD patients, target muscles injected with BoNT-A were selected by clinical evaluations and the results of needle electromyography (EMG) were considered as the gold standard. The sensitivity, specificity, and diagnostic efficacy of SPECT/CT were obtained from the receiver operator characteristic (ROC) curve. RESULTS: Twenty-four PCD patients were included in our study eventually, because three PCD patients whose follow-up were lost and 9 PCD patients whose maximum reduction of Tsui scale scores was < 80 % were ruled out. Normal muscles of healthy subjects showed mild symmetrical radioactivity distribution, while in PCD patients, [99mTc]MIBI uptake in dystonic muscles abnormally increased. The mean MBRs of dystonic muscles were significantly higher than those of normal muscles. The sensitivity, specificity, and area under the curve (AUC) of SPECT/CT were 93.2 %, 88.5 %, and 0.908, respectively. CONCLUSIONS: Our study indicated that [99mTc]MIBI SPECT/CT may be a useful method for identifying dystonic muscles and a guide to BoNT-A therapy in PCD patients.
PURPOSE: This study aimed to evaluate the usefulness of [99mTc]sestamibi ([99mTc]MIBI) single photon emission computed tomography (SPECT)/X-ray computed tomography (CT) imaging for the identification of dystonic muscles in primary cervical dystonia (PCD) patients who underwent botulinum neurotoxin type A (BoNT-A) therapy. PROCEDURES: Thirty-six patients with PCD and 10 healthy subjects (control group) who underwent [99mTc]MIBI SPECT/CT were enrolled. The image characteristics of dystonic muscles and normal muscles were evaluated. Muscle/background ratio (MBR) of six representative muscles was calculated for dystonic muscles in PCD group and normal muscles in control group. In PCDpatients, target muscles injected with BoNT-A were selected by clinical evaluations and the results of needle electromyography (EMG) were considered as the gold standard. The sensitivity, specificity, and diagnostic efficacy of SPECT/CT were obtained from the receiver operator characteristic (ROC) curve. RESULTS: Twenty-four PCDpatients were included in our study eventually, because three PCDpatients whose follow-up were lost and 9 PCDpatients whose maximum reduction of Tsui scale scores was < 80 % were ruled out. Normal muscles of healthy subjects showed mild symmetrical radioactivity distribution, while in PCDpatients, [99mTc]MIBI uptake in dystonic muscles abnormally increased. The mean MBRs of dystonic muscles were significantly higher than those of normal muscles. The sensitivity, specificity, and area under the curve (AUC) of SPECT/CT were 93.2 %, 88.5 %, and 0.908, respectively. CONCLUSIONS: Our study indicated that [99mTc]MIBI SPECT/CT may be a useful method for identifying dystonic muscles and a guide to BoNT-A therapy in PCDpatients.
Authors: G Arsos; A Kyparos; E Moralidis; D Kyparos; S Georga; S Sotiriadou; C Matziari; C Karakatsanis Journal: Physiol Res Date: 2008-01-17 Impact factor: 1.881