Literature DB >> 3171921

Biosynthesis of anthracyclinones.

K Eckardt1, C Wagner.   

Abstract

Recent biosynthetic studies confirmed that anthraquinones are involved as intermediates in the pathway to anthracyclines. The present knowledge in this field has been reviewed. Furthermore, a new generalized order of biosynthetic intermediates from the hypothetical polyketide to aklavinone and related anthracyclinones has been proposed involving tricyclic precursors and 7-hydroxy-naphthacenequinones, which also have been found in mutants of anthracycline-producing strains.

Entities:  

Mesh：

Substances：

Year:  1988        PMID： 3171921     DOI： 10.1002/jobm.3620280117

Source DB:  PubMed          Journal:  J Basic Microbiol        ISSN： 0233-111X            Impact factor:   2.281


  8 in total

1.  Cloning, sequencing, and analysis of aklaviketone reductase from Streptomyces sp. strain C5.

Authors:  M L Dickens; J Ye; W R Strohl
Journal:  J Bacteriol       Date:  1996-06       Impact factor: 3.490

Review 2.  Streptomycetes producing daunomycin and related compounds: do we know enough about them after 25 years?

Authors:  J Huk; M Blumauerova
Journal:  Folia Microbiol (Praha)       Date:  1989       Impact factor: 2.099

3.  Isolation and characterization of stable mutants of Streptomyces peucetius defective in daunorubicin biosynthesis.

Authors:  K S Vetrivel; K Dharmalingam
Journal:  J Genet       Date:  2001-04       Impact factor: 1.166

4.  Nucleotide sequences and expression of genes from Streptomyces purpurascens that cause the production of new anthracyclines in Streptomyces galilaeus.

Authors:  J Niemi; P Mäntsälä
Journal:  J Bacteriol       Date:  1995-05       Impact factor: 3.490

5.  Nucleotide sequence analysis of five putative Streptomyces griseus genes, one of which complements an early function in daunorubicin biosynthesis that is linked to a putative gene cluster involved in TDP-daunosamine formation.

Authors:  H Krügel; G Schumann; F Hänel; G Fiedler
Journal:  Mol Gen Genet       Date:  1993-10

6.  A bacterial analog of the mdr gene of mammalian tumor cells is present in Streptomyces peucetius, the producer of daunorubicin and doxorubicin.

Authors:  P G Guilfoile; C R Hutchinson
Journal:  Proc Natl Acad Sci U S A       Date:  1991-10-01       Impact factor: 11.205

7.  Aclacinomycin oxidoreductase (AknOx) from the biosynthetic pathway of the antibiotic aclacinomycin is an unusual flavoenzyme with a dual active site.

Authors:  Igor Alexeev; Azmiri Sultana; Pekka Mäntsälä; Jarmo Niemi; Gunter Schneider
Journal:  Proc Natl Acad Sci U S A       Date:  2007-03-29       Impact factor: 11.205

8.  Functional characterization and transcriptional analysis of a gene cluster governing early and late steps in daunorubicin biosynthesis in Streptomyces peucetius.

Authors:  K Madduri; C R Hutchinson
Journal:  J Bacteriol       Date:  1995-07       Impact factor: 3.490
  8 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.