Literature DB >> 31713164

Design and Implementing Pharmacogenomics Study in Cancer.

María Luisa Romero Lagunes1, Francisco Emilio Vera Badillo2,3.   

Abstract

The advances in technology has shifted healthcare from a "one size fits all" model to focus on personalized therapy. Understanding the relationship of genome variations and its effect on drug response has led to individualized drug selection, maximizing drug efficacy and improving toxicity profile. The developments in pharmacogenomics has led to the discovery of predictive and prognostic biomarkers, and has transformed cancer research leading to the creation of pharmacogenomics databases. While challenges associated with the implementation of pharmacogenomics based medicine exist, integrating data amongst collaborative networks will be crucial for researchers to identify all the functional elements of the human genome sequence. Future advances in the area of pharmacogenomics research will eventually lead to the identification of the right therapeutic drug for the right patient.

Entities:  

Keywords:  Computer-based systems; Germline mutations, somatic mutations; Health-care system; Molecular tumor board; Personalized medicine; Pharmacogenetics; Point-of-care method; Randomized trials; Whole exome sequencing

Mesh:

Year:  2019        PMID: 31713164     DOI: 10.1007/978-3-030-24100-1_4

Source DB:  PubMed          Journal:  Adv Exp Med Biol        ISSN: 0065-2598            Impact factor:   2.622


  2 in total

1.  Overview of Research on Germline Genetic Variation in Immune Genes and Cancer Outcomes.

Authors:  Brittany N Chao; Danielle M Carrick; Kelly K Filipski; Stefanie A Nelson
Journal:  Cancer Epidemiol Biomarkers Prev       Date:  2022-03-01       Impact factor: 4.090

Review 2.  Germline Variants That Affect Tumor Progression.

Authors:  Ajay Chatrath; Aakrosh Ratan; Anindya Dutta
Journal:  Trends Genet       Date:  2020-11-14       Impact factor: 11.639

  2 in total

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