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Literature DB >> 31712222

PTEN in Regulating Hematopoiesis and Leukemogenesis.

Abstract

PTEN is one of the most frequently mutated tumor suppressor genes in human cancers. By counteracting the PI3K/AKT/mTOR pathway, PTEN plays an essential role in regulating hematopoietic stem cells (HSCs) self-renewal, migration, lineage commitment, and differentiation. PTEN also plays important roles in suppressing leukemogenesis, especially T-cell acute lymphoblastic leukemia (T-ALL). Herein, we will review the function of PTEN in regulating hematopoiesis and leukemogenesis and discuss potential therapeutic approaches against leukemia with PTEN mutations.

Entities: Chemical

Mesh：

Substances：

Year: 2020 PMID： 31712222 PMCID： PMC7528863 DOI： 10.1101/cshperspect.a036244

Source DB: PubMed Journal: Cold Spring Harb Perspect Med ISSN： 2157-1422 Impact factor: 5.159

127 in total

1. Proposal of a genetic classifier for risk group stratification in pediatric T-cell lymphoblastic lymphoma reveals differences from adult T-cell lymphoblastic leukemia.

Authors: S T Balbach; O Makarova; B R Bonn; M Zimmermann; M Rohde; I Oschlies; W Klapper; C Rössig; B Burkhardt
Journal: Leukemia Date: 2015-07-28 Impact factor: 11.528

2. Epigenetic Memory Underlies Cell-Autonomous Heterogeneous Behavior of Hematopoietic Stem Cells.

Authors: Vionnie W C Yu; Rushdia Z Yusuf; Toshihiko Oki; Juwell Wu; Borja Saez; Xin Wang; Colleen Cook; Ninib Baryawno; Michael J Ziller; Eunjung Lee; Hongcang Gu; Alexander Meissner; Charles P Lin; Peter V Kharchenko; David T Scadden
Journal: Cell Date: 2016-11-17 Impact factor: 41.582

3. Negative regulation of neural stem/progenitor cell proliferation by the Pten tumor suppressor gene in vivo.

Authors: M Groszer; R Erickson; D D Scripture-Adams; R Lesche; A Trumpp; J A Zack; H I Kornblum; X Liu; H Wu
Journal: Science Date: 2001-11-01 Impact factor: 47.728

4. Identification of a lineage of multipotent hematopoietic progenitors.

Authors: S J Morrison; A M Wandycz; H D Hemmati; D E Wright; I L Weissman
Journal: Development Date: 1997-05 Impact factor: 6.868

5. Identification of Lin(-)Sca1(+)kit(+)CD34(+)Flt3- short-term hematopoietic stem cells capable of rapidly reconstituting and rescuing myeloablated transplant recipients.

Authors: Liping Yang; David Bryder; Jörgen Adolfsson; Jens Nygren; Robert Månsson; Mikael Sigvardsson; Sten Eirik W Jacobsen
Journal: Blood Date: 2004-11-30 Impact factor: 22.113

6. Myeloid-specific deletion of tumor suppressor PTEN augments neutrophil transendothelial migration during inflammation.

Authors: Bara Sarraj; Steffen Massberg; Yitang Li; Anongnard Kasorn; Kulandayan Subramanian; Fabien Loison; Leslie E Silberstein; Ulrich von Andrian; Hongbo R Luo
Journal: J Immunol Date: 2009-06-01 Impact factor: 5.422

7. Deletion of Pten in CD45-expressing cells leads to development of T-cell lymphoblastic lymphoma but not myeloid malignancies.

Authors: Cristina Mirantes; Maria Alba Dosil; David Hills; Jian Yang; Núria Eritja; Maria Santacana; Sònia Gatius; Felip Vilardell; Alexander Medvinsky; Xavier Matias-Guiu; Xavier Dolcet
Journal: Blood Date: 2016-01-14 Impact factor: 22.113

8. mTOR complex 1 plays critical roles in hematopoiesis and Pten-loss-evoked leukemogenesis.

Authors: Demetrios Kalaitzidis; Stephen M Sykes; Zhu Wang; Natalie Punt; Yuefeng Tang; Christine Ragu; Amit U Sinha; Steven W Lane; Amanda L Souza; Clary B Clish; Dimitrios Anastasiou; D Gary Gilliland; David T Scadden; David A Guertin; Scott A Armstrong
Journal: Cell Stem Cell Date: 2012-09-07 Impact factor: 24.633

9. Single-Cell RNA-Sequencing Reveals a Continuous Spectrum of Differentiation in Hematopoietic Cells.

Authors: Iain C Macaulay; Valentine Svensson; Charlotte Labalette; Lauren Ferreira; Fiona Hamey; Thierry Voet; Sarah A Teichmann; Ana Cvejic
Journal: Cell Rep Date: 2016-01-21 Impact factor: 9.423

10. PU.1 controls fibroblast polarization and tissue fibrosis.

Authors: Thomas Wohlfahrt; Simon Rauber; Steffen Uebe; Markus Luber; Alina Soare; Arif Ekici; Stefanie Weber; Alexandru-Emil Matei; Chih-Wei Chen; Christiane Maier; Emmanuel Karouzakis; Hans P Kiener; Elena Pachera; Clara Dees; Christian Beyer; Christoph Daniel; Kolja Gelse; Andreas E Kremer; Elisabeth Naschberger; Michael Stürzl; Falk Butter; Michael Sticherling; Susetta Finotto; Alexander Kreuter; Mark H Kaplan; Astrid Jüngel; Steffen Gay; Stephen L Nutt; David W Boykin; Gregory M K Poon; Oliver Distler; Georg Schett; Jörg H W Distler; Andreas Ramming
Journal: Nature Date: 2019-01-30 Impact factor: 49.962

3 in total