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Literature DB >> 31712215

Activity of Aerosolized Levofloxacin against Burkholderia cepacia in a Mouse Model of Chronic Lung Infection.

Abstract

Burkholderia cepacia complex is an opportunistic pathogen capable of causing chronic pulmonary infections. These studies were conducted to demonstrate the activity of aerosolized levofloxacin in a chronic mouse lung infection model caused by B. cepacia isolates from patients with cystic fibrosis. Treatment with aerosolized levofloxacin for 4 days produced at least 1 log CFU of bacterial killing against all strains tested, suggesting possible utility in the treatment of lung infections caused by B. cepacia isolates.

Entities: Chemical Disease Species

Keywords: B. cepaciazzm321990; aerosolized levofloxacin; mouse lung infection

Mesh：

Substances：

Year: 2020 PMID： 31712215 PMCID： PMC6985725 DOI： 10.1128/AAC.01988-19

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

16 in total

Review 1. A decade of Burkholderia cenocepacia virulence determinant research.

Authors: Slade A Loutet; Miguel A Valvano
Journal: Infect Immun Date: 2010-07-19 Impact factor: 3.441

Review 2. Burkholderia cepacia complex outbreaks among non-cystic fibrosis patients in the intensive care units: A review of adult and pediatric literature.

Authors: Mohammad Abdallah; Hassan A Abdallah; Ziad A Memish
Journal: Infez Med Date: 2018-12-01

3. Distribution of Burkholderia cepacia complex species among isolates recovered from persons with or without cystic fibrosis.

Authors: Rebecca Reik; Theodore Spilker; John J Lipuma
Journal: J Clin Microbiol Date: 2005-06 Impact factor: 5.948

4. Molecular epidemiology and antibiotic susceptibility of Burkholderia cepacia-complex isolates from an Italian cystic fibrosis centre.

Authors: G Golini; G Cazzola; R Fontana
Journal: Eur J Clin Microbiol Infect Dis Date: 2006-03 Impact factor: 3.267

5. Prevalence of Burkholderia species, including members of Burkholderia cepacia complex, among UK cystic and non-cystic fibrosis patients.

Authors: Dervla T D Kenna; Daniel Lilley; Amy Coward; Kate Martin; Claire Perry; Rachel Pike; Robert Hill; Jane F Turton
Journal: J Med Microbiol Date: 2017-04 Impact factor: 2.472

Review 6. Pseudomonas cepacia: biology, mechanisms of virulence, epidemiology.

Authors: D A Goldmann; J D Klinger
Journal: J Pediatr Date: 1986-05 Impact factor: 4.406

Review 7. Aerosol antibiotics: considerations in pharmacological and clinical evaluation.

Authors: Michael N Dudley; Jeff Loutit; David C Griffith
Journal: Curr Opin Biotechnol Date: 2008-11-25 Impact factor: 9.740

8. In vitro pharmacodynamics of levofloxacin and other aerosolized antibiotics under multiple conditions relevant to chronic pulmonary infection in cystic fibrosis.

Authors: Paula King; Olga Lomovskaya; David C Griffith; Jane L Burns; Michael N Dudley
Journal: Antimicrob Agents Chemother Date: 2009-10-05 Impact factor: 5.191

Review 9. Antibiotic treatment for Burkholderia cepacia complex in people with cystic fibrosis experiencing a pulmonary exacerbation.

Authors: Alex Horsley; Andrew M Jones; Robert Lord
Journal: Cochrane Database Syst Rev Date: 2016-01-20

Review 10. Burkholderia cenocepacia Infections in Cystic Fibrosis Patients: Drug Resistance and Therapeutic Approaches.

Authors: Viola C Scoffone; Laurent R Chiarelli; Gabriele Trespidi; Massimo Mentasti; Giovanna Riccardi; Silvia Buroni
Journal: Front Microbiol Date: 2017-08-22 Impact factor: 5.640

1 in total

Review 1. Methodological tools to study species of the genus Burkholderia.

Authors: Viola Camilla Scoffone; Gabriele Trespidi; Giulia Barbieri; Samuele Irudal; Aygun Israyilova; Silvia Buroni
Journal: Appl Microbiol Biotechnol Date: 2021-11-10 Impact factor: 4.813

1 in total