Literature DB >> 3171110

The effects of calcitonin on idiopathic nephrolithiasis. Evidence of bone involvement in fasting hypercalciuria.

P Filipponi1, C Mannarelli, G Gubbiotti, A Blass, I Moretti, S Tini, N Giuseppetti, S Ballanti, P Morucci.   

Abstract

This study was performed to evaluate the antihypercalciuric effect of calcitonin (CT), a potent inhibitor of bone osteoclastic activity, on idiopathic hypercalciuria (IH). Forty-two stone formers were studied: 18 suffered from fasting hypercalciuria (FH), 12 from nonfasting hypercalciuria (NFH) and 12 were normocalciuric stone formers (NSF). All patients received CT, 25 U/day sc for a period of 15 days. CT caused a statistically significant drop in urine calcium, phosphorus and hydroxyproline (OH-proline) excretion in FH patients and a concomitant increase in serum PTH levels. In this group the percentage variation (D%) of urine calcium decrease was linearly correlated with D% decrease in urine OH-proline. These results support the hypothesis that pathological bone reabsorption might be involved in the genesis of FH.

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Year:  1988        PMID： 3171110     DOI： 10.1007/BF03350171

Source DB:  PubMed          Journal:  J Endocrinol Invest        ISSN： 0391-4097            Impact factor:   4.256


  17 in total

1.  The role of 1 alpha, 25-dihydroxyvitamin D in the mediation of intestinal hyperabsorption of calcium in primary hyperparathyroidism and absorptive hypercalciuria.

Authors:  R A Kaplan; M R Haussler; L J Deftos; H Bone; C Y Pak
Journal:  J Clin Invest       Date:  1977-05       Impact factor: 14.808

2.  Bone mineral density in patients with urolithiasis. A preliminary report.

Authors:  E M Alhava; M Juuti; P Karjalainen
Journal:  Scand J Urol Nephrol       Date:  1976

3.  Bone mineral content in idiopathic calcium nephrolithiasis.

Authors:  J Barkin; D R Wilson; M A Manuel; A Bayley; T Murray; J Harrison
Journal:  Miner Electrolyte Metab       Date:  1985

4.  Pathophysiology of spontaneous hypercalciuria in laboratory rats. Role of deranged vitamin D metabolism.

Authors:  K Lau; D Thomas; C Langman; B Eby
Journal:  J Clin Invest       Date:  1985-08       Impact factor: 14.808

5.  Effects of sulindac and ibuprofen in patients with chronic glomerular disease. Evidence for the dependence of renal function on prostacyclin.

Authors:  G Ciabattoni; G A Cinotti; A Pierucci; B M Simonetti; M Manzi; F Pugliese; P Barsotti; G Pecci; F Taggi; C Patrono
Journal:  N Engl J Med       Date:  1984-02-02       Impact factor: 91.245

6.  Secondary hyperparathyroidism in idiopathic renal hypercalciuria: fact or theory?

Authors:  P Burckhardt; P Jaeger
Journal:  J Clin Endocrinol Metab       Date:  1981-09       Impact factor: 5.958

7.  Effect of calcitonin on calcium and magnesium transport in rat nephron.

Authors:  G A Quamme
Journal:  Am J Physiol       Date:  1980-06

8.  Effects of low-calcium diet on urine calcium excretion, parathyroid function and serum 1,25(OH)2D3 levels in patients with idiopathic hypercalciuria and in normal subjects.

Authors:  F L Coe; M J Favus; T Crockett; A L Strauss; J H Parks; A Porat; C L Gantt; L M Sherwood
Journal:  Am J Med       Date:  1982-01       Impact factor: 4.965

9.  Classification of idiopathic hypercalciuric patients by isotopic calcium absorption: a comparison with oral calcium tolerance test.

Authors:  R Pacifici; P Filipponi; C Mannarelli; G Vespasiani; M Porena; L Fedeli; V Morucci; L V Avioli
Journal:  Calcif Tissue Int       Date:  1985-09       Impact factor: 4.333

10.  Evidence that calcitonin stimulates 1,25-dihydroxyvitamin D production and intestinal absorption of calcium in vivo.

Authors:  P Jaeger; W Jones; T L Clemens; J P Hayslett
Journal:  J Clin Invest       Date:  1986-08       Impact factor: 14.808
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  2 in total

1.  Markers of bone turnover in patients with nephrolithiasis.

Authors:  M Kuczera; A Wiecek; F Kokot
Journal:  Int Urol Nephrol       Date:  1997       Impact factor: 2.370

2.  The cause of maintained hypercalciuria after the surgical cure of primary hyperparathyroidism is a defect in renal calcium reabsorption.

Authors:  M L Farias; A G Delgado; D Rosenthal; J G Vieira; T Kasamatsu; M J Lazarevitch; M F Pereira; M B Lima
Journal:  J Endocrinol Invest       Date:  1996-01       Impact factor: 4.256
  2 in total

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