| Literature DB >> 31705360 |
Qiuping Guo1,2,3,4,5, Fengna Li6,7,8,9,10, Yehui Duan1, Chaoyue Wen11, Wenlong Wang11, Lingyu Zhang1,2,3,4,5, Ruilin Huang1,2,3,4, Yulong Yin12,13,14,15,16.
Abstract
Free radical-induced oxidative stress contributes to the development of metabolic syndromes (Mets), including overweight, hyperglycemia, insulin resistance and pro-inflammatory state. Most free radicals are generated from the mitochondrial electron transport chain; under physiological conditions, their levels are maintained by efficient antioxidant systems. A variety of transcription factors have been identified and characterized that control gene expression in response to oxidative stress status. Natural antioxidant compounds have been largely studied for their strong antioxidant capacities. This review discusses the recent progress in oxidative stress and mitochondrial dysfunction in Mets and highlights the anti-Mets, anti-oxidative, and anti-inflammatory effect of polyphenols as potential nutritional therapy.Entities:
Keywords: mitochondrial dysfunction; nutritional antioxidant; oxidative stress; polyphenols; reactive oxygen species; signal transduction
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Year: 2019 PMID: 31705360 DOI: 10.1007/s11427-019-9591-5
Source DB: PubMed Journal: Sci China Life Sci ISSN: 1674-7305 Impact factor: 6.038