Literature DB >> 31705229

Disparities in the use of stereotactic radiosurgery for the treatment of lung cancer brain metastases: a SEER-Medicare study.

Mustafa S Ascha1, Kaitlyn Funk2, Andrew E Sloan3, Carol Kruchko4, Jill S Barnholtz-Sloan5.   

Abstract

Stereotactic radiosurgery (SRS) is a costly procedure used to irradiate disease tissue while sparing healthy tissue, ideally limiting the side effects of treatment. SRS is frequently used in the setting of lung cancer, which is associated with greater rates of BM, though its cost may lead to potentially inequitable use across patient populations. This study investigates potential disparities in the use of SRS to treat Medicare patients. Surveillance, Epidemiology, and End-Results cancer registry data for patients diagnosed between the years 2010 and 2012 were examined to identify lung cancer patients diagnosed with BM at the same time as their primary cancer (SBM). Medicare claims for SRS were identified; the odds of having SRS claims and hazards of mortality associated with those odds were examined with respect to various clinical and demographic characteristics. Of 74,142 Medicare-enrolled patients diagnosed with lung cancer, 9192 were diagnosed with SBM and 3259 of those patients received SRS. Adjusting for clinical and demographic characteristics, males with SBM had 0.85 times the odds of SRS compared to females with SBM. Black patients and those of other race had significantly lower odds of evidence of SRS compared to WNH patients. SRS may not be delivered equitably among Medicare patients. Males and minority patients may have decreased odds of SRS and worse survival compared to female and WNH patients, respectively.

Entities:  

Keywords:  Lung cancer brain metastases; Observational study; Real-world evidence; SEER-Medicare; Stereotactic radiosurgery

Year:  2019        PMID: 31705229     DOI: 10.1007/s10585-019-10005-2

Source DB:  PubMed          Journal:  Clin Exp Metastasis        ISSN: 0262-0898            Impact factor:   5.150


  20 in total

1.  EGFR mutation and brain metastasis in pulmonary adenocarcinomas.

Authors:  Dong-Yeop Shin; Im Il Na; Cheol Hyeon Kim; Sunhoo Park; HeeJong Baek; Sung Hyun Yang
Journal:  J Thorac Oncol       Date:  2014-02       Impact factor: 15.609

2.  Comparative effectiveness of stereotactic radiosurgery versus whole-brain radiation therapy for patients with brain metastases from breast or non-small cell lung cancer.

Authors:  Lia M Halasz; Hajime Uno; Melissa Hughes; Thomas D'Amico; Elisabeth U Dexter; Stephen B Edge; James A Hayman; Joyce C Niland; Gregory A Otterson; Katherine M W Pisters; Richard Theriault; Jane C Weeks; Rinaa S Punglia
Journal:  Cancer       Date:  2016-04-18       Impact factor: 6.860

3.  Comparative survival in patients with brain metastases from non-small-cell lung cancer treated before and after implementation of radiosurgery.

Authors:  J N Greenspoon; P M Ellis; G Pond; S Caetano; J Broomfield; A Swaminath
Journal:  Curr Oncol       Date:  2017-04-27       Impact factor: 3.677

4.  Use of Stereotactic Radiosurgery in Elderly and Very Elderly Patients With Brain Metastases to Limit Toxicity Associated With Whole Brain Radiation Therapy.

Authors:  Linda Chen; Colette Shen; Kristin J Redmond; Brandi R Page; Megan Kummerlowe; Todd Mcnutt; Chetan Bettegowda; Daniele Rigamonti; Michael Lim; Lawrence Kleinberg
Journal:  Int J Radiat Oncol Biol Phys       Date:  2017-02-21       Impact factor: 7.038

5.  Regularization Paths for Generalized Linear Models via Coordinate Descent.

Authors:  Jerome Friedman; Trevor Hastie; Rob Tibshirani
Journal:  J Stat Softw       Date:  2010       Impact factor: 6.440

Review 6.  Treatment of brain metastases from lung cancer: chemotherapy.

Authors:  Wolfgang Schuette
Journal:  Lung Cancer       Date:  2004-08       Impact factor: 5.705

7.  Estimating the annual frequency of synchronous brain metastasis in the United States 2010-2013: a population-based study.

Authors:  Courtney Kromer; Jordan Xu; Quinn T Ostrom; Haley Gittleman; Carol Kruchko; Raymond Sawaya; Jill S Barnholtz-Sloan
Journal:  J Neurooncol       Date:  2017-05-31       Impact factor: 4.130

8.  The Burden of Cancer in Asian Americans: A Report of National Mortality Trends by Asian Ethnicity.

Authors:  Caroline A Thompson; Scarlett Lin Gomez; Katherine G Hastings; Kristopher Kapphahn; Peter Yu; Salma Shariff-Marco; Ami S Bhatt; Heather A Wakelee; Manali I Patel; Mark R Cullen; Latha P Palaniappan
Journal:  Cancer Epidemiol Biomarkers Prev       Date:  2016-10       Impact factor: 4.254

9.  Lung cancer incidence trends by gender, race and histology in the United States, 1973-2010.

Authors:  Rafael Meza; Clare Meernik; Jihyoun Jeon; Michele L Cote
Journal:  PLoS One       Date:  2015-03-30       Impact factor: 3.240

10.  Racial and Gender Disparities in Incidence of Lung and Bronchus Cancer in the United States: A Longitudinal Analysis.

Authors:  Mohammad A Tabatabai; Jean-Jacques Kengwoung-Keumo; Gabriela R Oates; Juliette T Guemmegne; Akinola Akinlawon; Green Ekadi; Mona N Fouad; Karan P Singh
Journal:  PLoS One       Date:  2016-09-29       Impact factor: 3.240

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  4 in total

1.  Impact of socio-economic factors on radiation treatment after resection of metastatic brain tumors: trends from a private insurance database.

Authors:  David Y A Dadey; Adrian Rodrigues; Ghani Haider; Erqi L Pollom; John R Adler; Anand Veeravagu
Journal:  J Neurooncol       Date:  2022-05-21       Impact factor: 4.130

2.  Racial disparities in supportive medication use among older patients with brain metastases: a population-based analysis.

Authors:  Nayan Lamba; Elie Mehanna; Rachel B Kearney; Paul J Catalano; Daphne A Haas-Kogan; Brian M Alexander; Daniel N Cagney; Kathleen A Lee; Ayal A Aizer
Journal:  Neuro Oncol       Date:  2020-09-29       Impact factor: 12.300

3.  Improved Survival With Surgical Treatment of Primary Lung Lesions in Non-Small Cell Lung Cancer With Brain Metastases: A Propensity-Matched Analysis of Surveillance, Epidemiology, and End Results Database.

Authors:  Qing Wang; Jing Li; Xiaohua Liang; Qiong Zhan
Journal:  Front Oncol       Date:  2022-07-22       Impact factor: 5.738

Review 4.  Sociodemographic disparities in the management of advanced lung cancer: a narrative review.

Authors:  Jacob Newton Stein; M Patricia Rivera; Ashley Weiner; Narjust Duma; Louise Henderson; Gita Mody; Marjory Charlot
Journal:  J Thorac Dis       Date:  2021-06       Impact factor: 3.005

  4 in total

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