| Literature DB >> 31703966 |
Paula Desplats1, Ashley M Gutierrez2, Marta C Antonelli3, Martin G Frasch4.
Abstract
We review evidence supporting the role of early life programming in the susceptibility for adult neurodegenerative diseases while highlighting questions and proposing avenues for future research to advance our understanding of this fundamental process. The key elements of this phenomenon are chronic stress, neuroinflammation triggering microglial polarization, microglial memory and their connection to neurodegeneration. We review the mediating mechanisms which may function as early biomarkers of increased susceptibility for neurodegeneration. Can we devise novel early life modifying interventions to steer developmental trajectories to their optimum?Entities:
Keywords: Alzheimer's; Animal models; CHRNA7; Early life; Enriched environment; Glia; Neuroinflammation; Parkinson's; Policy; Pregnancy stress
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Year: 2019 PMID： 31703966 PMCID： PMC7198341 DOI： 10.1016/j.neubiorev.2019.10.013
Source DB: PubMed Journal: Neurosci Biobehav Rev ISSN： 0149-7634 Impact factor: 8.989