Literature DB >> 31701858

Case Report: Highlighting Male Genital Schistosomiasis (MGS) in Fishermen from the Southwestern Shoreline of Lake Malawi, Mangochi District.

Sekeleghe A Kayuni1,2, E James LaCourse1, Peter Makaula3, Fanuel Lampiao4, Lazarus Juziwelo5, Joanna Fawcett1, Alexandra Shaw1, Mohammad H Alharbi1, Jaco J Verweij6, J Russell Stothard1.   

Abstract

Urogenital schistosomiasis causes morbidity within the genitalia but is underreported and infrequently examined in men. To draw attention to male genital schistosomiasis (MGS), a longitudinal cohort study was conducted among fishermen along the southwestern shoreline of Lake Malawi. A case series of five participants is presented inclusive of questionnaire interviews, parasitological examinations, ultrasonography, and provision of a standard dose (40 mg/kg) of praziquantel (PZQ) treatment at baseline, 1-, 3-, 6-, and 12-month follow-up time points. Eggs of Schistosoma haematobium were observed in urine or semen across all time points; parasitological diagnostics were bolstered by real-time PCR for Schistosoma DNA in semen and by portable ultrasonography to document putative MGS-associated morbidity. We highlight the importance of developing standard diagnostic tests for MGS and increasing the accessibility of PZQ treatment to men, especially those in at-risk endemic areas.

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Year:  2019        PMID: 31701858      PMCID: PMC6896877          DOI: 10.4269/ajtmh.19-0562

Source DB:  PubMed          Journal:  Am J Trop Med Hyg        ISSN: 0002-9637            Impact factor:   2.345


  15 in total

1.  Considering treatment of male genital schistosomiasis as a tool for future HIV prevention: a systematic review.

Authors:  Chalotte Willemann Stecher; Per Kallestrup; Eyrun Floerecke Kjetland; Birgitte Vennervald; Eskild Petersen
Journal:  Int J Public Health       Date:  2015-08-23       Impact factor: 3.380

2.  Impact of short-time urine freezing on the sensitivity of an established Schistosoma real-time PCR assay.

Authors:  Hilaire M Kenguele; Ayola A Adegnika; Anne-Marie Nkoma; Ulysse Ateba-Ngoa; Mirabeau Mbong; Jeannot Zinsou; Bertrand Lell; Jaco J Verweij
Journal:  Am J Trop Med Hyg       Date:  2014-04-07       Impact factor: 2.345

Review 3.  Schistosomiasis.

Authors:  Donald P McManus; David W Dunne; Moussa Sacko; Jürg Utzinger; Birgitte J Vennervald; Xiao-Nong Zhou
Journal:  Nat Rev Dis Primers       Date:  2018-08-09       Impact factor: 52.329

4.  Schistosomiasis of the male pelvic organs. Severity of infection as determined by digestion of tissue and histologic methods in 300 cadavers.

Authors:  M Gelfand; C M Ross; D M Blair; W M Castle; M C Weber
Journal:  Am J Trop Med Hyg       Date:  1970-09       Impact factor: 2.345

5.  Community-based study of genital schistosomiasis in men from Madagascar.

Authors:  P Leutscher; C E Ramarokoto; C Reimert; H Feldmeier; P Esterre; B J Vennervald
Journal:  Lancet       Date:  2000-01-08       Impact factor: 79.321

6.  Coexistence of urogenital schistosomiasis and sexually transmitted infection in women and men living in an area where Schistosoma haematobium is endemic.

Authors:  Peter Derek Christian Leutscher; Charles-Emile Ramarokoto; S Hoffmann; Jørgen S Jensen; V Ramaniraka; B Randrianasolo; C Raharisolo; R Migliani; N Christensen
Journal:  Clin Infect Dis       Date:  2008-09-15       Impact factor: 9.079

7.  Decrease in Seminal HIV-1 RNA Load After Praziquantel Treatment of Urogenital Schistosomiasis Coinfection in HIV-Positive Men-An Observational Study.

Authors:  Nicholas Midzi; Takafira Mduluza; Boniface Mudenge; Leslie Foldager; Peter D C Leutscher
Journal:  Open Forum Infect Dis       Date:  2017-09-15       Impact factor: 3.835

Review 8.  Schistosomiasis in Malawi: a systematic review.

Authors:  Peter Makaula; John R Sadalaki; Adamson S Muula; Sekeleghe Kayuni; Samuel Jemu; Paul Bloch
Journal:  Parasit Vectors       Date:  2014-12-10       Impact factor: 3.876

9.  Knowledge and awareness of genital involvement and reproductive health consequences of urogenital schistosomiasis in endemic communities in Ghana: a cross-sectional study.

Authors:  Dzidzo R Yirenya-Tawiah; Mercy M Ackumey; Kwabena M Bosompem
Journal:  Reprod Health       Date:  2016-09-21       Impact factor: 3.223

Review 10.  A systematic review with epidemiological update of male genital schistosomiasis (MGS): A call for integrated case management across the health system in sub-Saharan Africa.

Authors:  Sekeleghe Kayuni; Fanuel Lampiao; Peter Makaula; Lazarus Juziwelo; E James Lacourse; Jutta Reinhard-Rupp; Peter D C Leutscher; J Russell Stothard
Journal:  Parasite Epidemiol Control       Date:  2018-11-23
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  5 in total

1.  Schistosomiasis Control Under Changing Ecological Settings in Lake Malawi.

Authors:  Henry Madsen; Jay Richard Stauffer
Journal:  Ecohealth       Date:  2022-08-05       Impact factor: 4.464

Review 2.  The Road to Elimination: Current State of Schistosomiasis Research and Progress Towards the End Game.

Authors:  Paul Ogongo; Ruth K Nyakundi; Gerald K Chege; Lucy Ochola
Journal:  Front Immunol       Date:  2022-05-03       Impact factor: 8.786

Review 3.  The parasitology of female genital schistosomiasis.

Authors:  Verner N Orish; Emmanuel Komla Senanu Morhe; Wisdom Azanu; Robert K Alhassan; Margaret Gyapong
Journal:  Curr Res Parasitol Vector Borne Dis       Date:  2022-05-27

4.  An assessment of implementation and effectiveness of mass drug administration for prevention and control of schistosomiasis and soil-transmitted helminths in selected southern Malawi districts.

Authors:  Peter Makaula; Sekeleghe Amos Kayuni; Kondwani Chidzammbuyo Mamba; Grace Bongololo; Mathias Funsanani; Janelisa Musaya; Lazarus Tito Juziwelo; Peter Furu
Journal:  BMC Health Serv Res       Date:  2022-04-19       Impact factor: 2.908

5.  Pathological Abnormalities Observed on Ultrasonography among Fishermen Associated with Male Genital Schistosomiasis (MGS) along the South Lake Malawi Shoreline in Mangochi District, Malawi.

Authors:  Sekeleghe A Kayuni; Mohammad H Al-Harbi; Peter Makaula; Boniface Injesi; Bright Mainga; Fanuel Lampiao; Lazarus Juziwelo; E James LaCourse; J Russell Stothard
Journal:  Trop Med Infect Dis       Date:  2022-08-05
  5 in total

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