Shantanu Solanki1, Khwaja Fahad Haq2, Raja Chandra Chakinala3, Zubair Khan4, Wilbert S Aronow5, Muhammad Ali Khan6, Mohamed Tausif Siddiqui3, Khwaja Saad Haq7, Shalom Frager8, Maryam Alimirah9, Christopher Nabors3, David J Samson10, Edward Lebovics8, David Cary Wolf8. 1. Hospitalist Department, Guthrie Robert Packer Hospital, Sayre, PA, USA. 2. Division of Gastroenterology, Henry Ford Hospital, Detroit, MI, USA. 3. Department of Medicine, New York Medical College at Westchester Medical Center, Valhalla, NY, USA. 4. Department of Gastroenterology, Hepatology & Nutrition, The University of Texas Health Science Center at Houston, Houston, TX, USA. 5. Department of Cardiology, New York Medical College at Westchester Medical Center, Valhalla, NY, USA. 6. Division of Gastroenterology, University of Tennessee Health Science Center, Memphis, TN, USA. 7. Department of Medicine, Kingsbrook Jewish Medical Center, Brooklyn, NY, USA. 8. Division of Gastroenterology & Hepatobiliary Diseases, New York Medical College at Westchester Medical Center, Valhalla, NY, USA. 9. Department of Medicine, Henry Ford Hospital, Detroit, MI, USA. 10. Clinical Research Unit, Department of Surgery, Westchester Medical Center, Valhalla, NY, USA.
Abstract
BACKGROUND: Esophageal variceal bleeding remains a common reason for hospitalization in the United States. The main objective of this study was to analyze demographic variations and outcomes in hospitalizations related to esophageal varices (EV) in the US. METHODS: We performed a retrospective observational cohort study using National Inpatient Sample (NIS) database for all hospitalizations with discharge diagnoses of EV, with and without hemorrhage from 2001 to 2011. RESULTS: In 2001, there were 19,167 hospitalizations with discharge diagnoses of EV with and without bleeding compared to 45,578 in 2011 (P<0.001). There was a 138% increase in the number of total EV hospitalizations, a 221% increase in hospitalizations with EV without hemorrhage, and a 7% increase in hospitalizations for patients with EV and hemorrhage. Age group 50-64 was the most affected, accounting for 31.4% of EV hospitalizations in 2001 and 46.7% of EV hospitalizations in 2011 (P<0.001). The overall in-hospital mortality rate was 3.4% for patients with EV without hemorrhage and 8.7% for patients with EV with hemorrhage (P=0.0003). CONCLUSIONS: The number of hospitalizations for patients with asymptomatic EV increased significantly between 2001 to 2011, with only a small concurrent increase in the number of hospitalizations for patients with esophageal variceal bleeding. 2019 Annals of Translational Medicine. All rights reserved.
BACKGROUND: Esophageal variceal bleeding remains a common reason for hospitalization in the United States. The main objective of this study was to analyze demographic variations and outcomes in hospitalizations related to esophageal varices (EV) in the US. METHODS: We performed a retrospective observational cohort study using National Inpatient Sample (NIS) database for all hospitalizations with discharge diagnoses of EV, with and without hemorrhage from 2001 to 2011. RESULTS: In 2001, there were 19,167 hospitalizations with discharge diagnoses of EV with and without bleeding compared to 45,578 in 2011 (P<0.001). There was a 138% increase in the number of total EV hospitalizations, a 221% increase in hospitalizations with EV without hemorrhage, and a 7% increase in hospitalizations for patients with EV and hemorrhage. Age group 50-64 was the most affected, accounting for 31.4% of EV hospitalizations in 2001 and 46.7% of EV hospitalizations in 2011 (P<0.001). The overall in-hospital mortality rate was 3.4% for patients with EV without hemorrhage and 8.7% for patients with EV with hemorrhage (P=0.0003). CONCLUSIONS: The number of hospitalizations for patients with asymptomatic EV increased significantly between 2001 to 2011, with only a small concurrent increase in the number of hospitalizations for patients with esophageal variceal bleeding. 2019 Annals of Translational Medicine. All rights reserved.
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