Literature DB >> 31700198

Time-dependent saddle-node bifurcation: Breaking time and the point of no return in a non-autonomous model of critical transitions.

Jeremiah H Li1, Felix X-F Ye2, Hong Qian1, Sui Huang3.   

Abstract

There is a growing awareness that catastrophic phenomena in biology and medicine can be mathematically represented in terms of saddle-node bifurcations. In particular, the term "tipping", or critical transition has in recent years entered the discourse of the general public in relation to ecology, medicine, and public health. The saddle-node bifurcation and its associated theory of catastrophe as put forth by Thom and Zeeman has seen applications in a wide range of fields including molecular biophysics, mesoscopic physics, and climate science. In this paper, we investigate a simple model of a non-autonomous system with a time-dependent parameter p(τ) and its corresponding "dynamic" (time-dependent) saddle-node bifurcation by the modern theory of non-autonomous dynamical systems. We show that the actual point of no return for a system undergoing tipping can be significantly delayed in comparison to the breaking time τ ^ at which the corresponding autonomous system with a time-independent parameter p a = p ( τ ^ ) undergoes a bifurcation. A dimensionless parameter α = λ p 0 3 V - 2 is introduced, in which λ is the curvature of the autonomous saddle-node bifurcation according to parameter p(τ), which has an initial value of p 0 and a constant rate of change V. We find that the breaking time τ ^ is always less than the actual point of no return τ ∗ after which the critical transition is irreversible; specifically, the relation τ * - τ ^ ≃ 2.338 ( λ V ) - 1 3 is analytically obtained. For a system with a small λV, there exists a significant window of opportunity ( τ ^ , τ ∗) during which rapid reversal of the environment can save the system from catastrophe.

Entities:  

Year:  2019        PMID: 31700198      PMCID: PMC6836434          DOI: 10.1016/j.physd.2019.02.005

Source DB:  PubMed          Journal:  Physica D        ISSN: 0167-2789            Impact factor:   2.300


  13 in total

Review 1.  From discrete protein kinetics to continuous Brownian dynamics: a new perspective.

Authors:  Hong Qian
Journal:  Protein Sci       Date:  2002-01       Impact factor: 6.725

Review 2.  Cooperativity in cellular biochemical processes: noise-enhanced sensitivity, fluctuating enzyme, bistability with nonlinear feedback, and other mechanisms for sigmoidal responses.

Authors:  Hong Qian
Journal:  Annu Rev Biophys       Date:  2012-02-23       Impact factor: 12.981

3.  Scaling laws for dynamical hysteresis in a multidimensional laser system.

Authors: 
Journal:  Phys Rev Lett       Date:  1995-03-20       Impact factor: 9.161

Review 4.  The tipping point for combination therapy: cancer vaccines with radiation, chemotherapy, or targeted small molecule inhibitors.

Authors:  James W Hodge; Andressa Ardiani; Benedetto Farsaci; Anna R Kwilas; Sofia R Gameiro
Journal:  Semin Oncol       Date:  2012-06       Impact factor: 4.929

Review 5.  Early-warning signals for critical transitions.

Authors:  Marten Scheffer; Jordi Bascompte; William A Brock; Victor Brovkin; Stephen R Carpenter; Vasilis Dakos; Hermann Held; Egbert H van Nes; Max Rietkerk; George Sugihara
Journal:  Nature       Date:  2009-09-03       Impact factor: 49.962

Review 6.  Systems biology of stem cells: three useful perspectives to help overcome the paradigm of linear pathways.

Authors:  Sui Huang
Journal:  Philos Trans R Soc Lond B Biol Sci       Date:  2011-08-12       Impact factor: 6.237

7.  Stochastic phenotype transition of a single cell in an intermediate region of gene state switching.

Authors:  Hao Ge; Hong Qian; X Sunney Xie
Journal:  Phys Rev Lett       Date:  2015-02-17       Impact factor: 9.161

8.  At the tipping point for epigenetic therapies in cancer.

Authors:  Peter A Jones
Journal:  J Clin Invest       Date:  2014-01-02       Impact factor: 14.808

Review 9.  Tumor progression: chance and necessity in Darwinian and Lamarckian somatic (mutationless) evolution.

Authors:  Sui Huang
Journal:  Prog Biophys Mol Biol       Date:  2012-05-11       Impact factor: 3.667

10.  Detecting early-warning signals for sudden deterioration of complex diseases by dynamical network biomarkers.

Authors:  Luonan Chen; Rui Liu; Zhi-Ping Liu; Meiyi Li; Kazuyuki Aihara
Journal:  Sci Rep       Date:  2012-03-29       Impact factor: 4.379

View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.