Literature DB >> 3170

The action of chelating agents on human liver aldehyde dehydrogenase.

R S Sidhu, A H Blair.   

Abstract

Human liver aldehyde dehydrogenase was inhibited by aromatic chelating agents. However, structurally related compounds with much lower metal-complexing ability displayed affinities for enzyme essentially equal to those of their respective chelating analogues. Inhibition was competitive with respect to the coenzyme. It is suggested that hydrophobic interactions between the inhibitors and the coenzyme-binding site of the enzyme are responsible for the observed effects on activity.

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Year:  1975        PMID： 3170      PMCID： PMC1172377          DOI： 10.1042/bj1510443

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  12 in total

1.  Computer programmes for processing enzyme kinetic data.

Authors:  W W CLELAND
Journal:  Nature       Date:  1963-05-04       Impact factor: 49.962

2.  Complex formation of 1,10-phenanthroline with zinc ions and the zinc of alcohol dehydrogenase of horse liver.

Authors:  B L VALLEE; T L COOMBS
Journal:  J Biol Chem       Date:  1959-10       Impact factor: 5.157

3.  The effect of metal-binding agents on aldehyde dehydrogenases.

Authors:  M N SCHWARCZ; A O STOPPANI
Journal:  Biochim Biophys Acta       Date:  1960-04-08

4.  Structure of liver alcohol dehydrogenase at 2.9-angstrom resolution.

Authors:  C I Brändén; H Eklund; B Nordström; T Boiwe; G Söderlund; E Zeppezauer; I Ohlsson; A Akeson
Journal:  Proc Natl Acad Sci U S A       Date:  1973-08       Impact factor: 11.205

5.  Human liver aldehyde dehydrogenase: partial purification and properties.

Authors:  A H Blair; F H Bodley
Journal:  Can J Biochem       Date:  1969-03

6.  Yeast aldehyde dehydrogenase. I. Purification and crystallization.

Authors:  C R Steinman; W B Jakoby
Journal:  J Biol Chem       Date:  1967-11-10       Impact factor: 5.157

7.  Nitrogen base inhibition of yeast alcohol dehydrogenase.

Authors:  B M Anderson; M L Reynolds; C D Anderson
Journal:  Biochim Biophys Acta       Date:  1966-02-14

8.  Action of zinc-complexing agents on nicotinamide adenine dinucleotide-linked aldehyde dehydrogenases from yeast and liver.

Authors:  A O Stoppani; M N Schwarcz; C E Freda
Journal:  Arch Biochem Biophys       Date:  1966-02       Impact factor: 4.013

9.  Differential chemical reactivities of zinc in horse liver alcohol dehydrogenase.

Authors:  D E Drum; B L Vallee
Journal:  Biochemistry       Date:  1970-10-13       Impact factor: 3.162

10.  Considerations in evaluating the zinc content of horse liver alcohol dehydrogenase preparations.

Authors:  D E Drum; T K Li; B L Vallee
Journal:  Biochemistry       Date:  1969-09       Impact factor: 3.162
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  3 in total

1.  Evidence for the nonhydrophobic interaction of aromatic, nitrogen-containing compounds with the coenzyme binding site of a NAD-linked D-lactate dehydrogenase.

Authors:  G L Long; J R Cook; W R Ellington
Journal:  Experientia       Date:  1978-05-15

2.  The action of progesterone and diethylstilboestrol on the dehydrogenase and esterase activities of a purified aldehyde dehydrogenase from rabbit liver.

Authors:  R Julian; S Duncan
Journal:  Biochem J       Date:  1977-01-01       Impact factor: 3.857

3.  The activation of aldehyde dehydrogenase by diethylstilboestrol and 2,2'-dithiodipyridine.

Authors:  T M Kitson
Journal:  Biochem J       Date:  1982-10-01       Impact factor: 3.857
  3 in total

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