Literature DB >> 3169966

Effect of recombinant DNA-produced tumor necrosis factor on various parameters of neutrophil function.

Y Ozaki1, T Ohashi, Y Niwa, S Kume.   

Abstract

The effect of recombinant DNA-produced human tumor necrosis factor (TNF) on various parameters of neutrophil function was evaluated. TNF was a weak direct activator of oxygen radical production. It released the specific granule contents to a limited extent, but the azurophilic granule contents were retained even in the presence of cytochalasin B. It had a chemotactic activity for neutrophils, as determined by the use of a modified Boyden's chamber. Pretreatment of neutrophils with TNF increased phagocytosis of opsonized particles and markedly potentiated in a dose-dependent manner oxygen radical production induced by opsonized zymosan. The inhibitors of lipoxygenase, but not those of cyclooxygenase, reduced the potentiating effect of TNF on phagocytosis, suggesting that the products of lipoxygenase play an important role in mediating the effect of TNF on neutrophils.

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Year:  1988        PMID： 3169966     DOI： 10.1007/bf00915767

Source DB:  PubMed          Journal:  Inflammation        ISSN： 0360-3997            Impact factor:   4.092


  30 in total

1.  Intracellular control of human neutrophil secretion. I. C5a-induced stimulus-specific desensitization and the effects of cytochalasin B.

Authors:  P M Henson; B Zanolari; N A Schwartzman; S R Hong
Journal:  J Immunol       Date:  1978-09       Impact factor: 5.422

2.  Evaluation of opsonic and leukocyte function with a spectrophotometric test in patients with infection and with phagocytic disorders.

Authors:  T P Stossel
Journal:  Blood       Date:  1973-07       Impact factor: 22.113

3.  A comparative study on the effects of inhibitors of the lipoxygenase pathway on neutrophil function. Inhibitory effects on neutrophil function may not be attributed to inhibition of the lipoxygenase pathway.

Authors:  Y Ozaki; T Ohashi; Y Niwa
Journal:  Biochem Pharmacol       Date:  1986-10-15       Impact factor: 5.858

4.  Oxygen radical production by neutrophils from patients with bacterial infection and rheumatoid arthritis. Measurement of hydrogen peroxide may most accurately represent enhancement of oxygen radical production during infection.

Authors:  Y Ozaki; T Ohashi; Y Niwa
Journal:  Inflammation       Date:  1986-06       Impact factor: 4.092

5.  Human leukocytic pyrogen induces release of specific granule contents from human neutrophils.

Authors:  M S Klempner; C A Dinarello; J I Gallin
Journal:  J Clin Invest       Date:  1978-05       Impact factor: 14.808

6.  Pharmacological profile of AA-861, a 5-lipoxygenase inhibitor.

Authors:  Y Ashida; T Saijo; H Kuriki; H Makino; S Terao; Y Maki
Journal:  Prostaglandins       Date:  1983-12

7.  H2O2 release from human granulocytes during phagocytosis. Relationship to superoxide anion formation and cellular catabolism of H2O2: studies with normal and cytochalasin B-treated cells.

Authors:  R K Root; J A Metcalf
Journal:  J Clin Invest       Date:  1977-12       Impact factor: 14.808

8.  Stimulation of the adherence of neutrophils to umbilical vein endothelium by human recombinant tumor necrosis factor.

Authors:  J R Gamble; J M Harlan; S J Klebanoff; M A Vadas
Journal:  Proc Natl Acad Sci U S A       Date:  1985-12       Impact factor: 11.205

9.  Hyperactivity of neutrophil leukotactic responses during active bacterial infection.

Authors:  H R Hill; J M Gerrard; N A Hogan; P G Quie
Journal:  J Clin Invest       Date:  1974-04       Impact factor: 14.808

10.  Cloning and expression in Escherichia coli of the gene for human tumour necrosis factor.

Authors:  T Shirai; H Yamaguchi; H Ito; C W Todd; R B Wallace
Journal:  Nature       Date:  1985 Feb 28-Mar 6       Impact factor: 49.962
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  6 in total

1.  Re-evaluation of the chemotactic activity of tumour necrosis factor for monocytes.

Authors:  J M Wang; S Walter; A Mantovani
Journal:  Immunology       Date:  1990-11       Impact factor: 7.397

2.  Effect of platelet-activating factor on tumor necrosis factor-induced superoxide generation from human neutrophils. Possible involvement of G proteins.

Authors:  P Braquet; D Hosford; P Koltz; J Guilbaud; M Paubert-Braquet
Journal:  Lipids       Date:  1991-12       Impact factor: 1.880

3.  Neutrophil-potentiating factors released from stimulated lymphocytes; special reference to the increase in neutrophil-potentiating factors from streptococcus-stimulated lymphocytes of patients with Behçet's disease.

Authors:  Y Niwa; Y Mizushima
Journal:  Clin Exp Immunol       Date:  1990-03       Impact factor: 4.330

4.  Priming of human neutrophil functions by tumor necrosis factor: enhancement of superoxide anion generation, degranulation, and chemotaxis to chemoattractants C5a and F-Met-Leu-Phe.

Authors:  M S Bajaj; R R Kew; R O Webster; T M Hyers
Journal:  Inflammation       Date:  1992-06       Impact factor: 4.092

5.  Lactoferrin release and interleukin-1, interleukin-6, and tumor necrosis factor production by human polymorphonuclear cells stimulated by various lipopolysaccharides: relationship to growth inhibition of Candida albicans.

Authors:  C Palma; A Cassone; D Serbousek; C A Pearson; J Y Djeu
Journal:  Infect Immun       Date:  1992-11       Impact factor: 3.441

6.  Undetectable interleukin (IL)-10 and persistent IL-8 expression early in hyaline membrane disease: a possible developmental basis for the predisposition to chronic lung inflammation in preterm newborns.

Authors:  C A Jones; R G Cayabyab; K Y Kwong; C Stotts; B Wong; H Hamdan; P Minoo; R A deLemos
Journal:  Pediatr Res       Date:  1996-06       Impact factor: 3.756
  6 in total

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