Literature DB >> 31698143

Cytochrome P450 derived epoxidized fatty acids as a therapeutic tool against neuroinflammatory diseases.

Jogen Atone1, Karen Wagner1, Kenji Hashimoto2, Bruce D Hammock3.   

Abstract

Cytochrome P450 (CYP) metabolism of arachidonic acid (ARA) produces epoxy fatty acids (EpFAs) such as epoxyeicosatrienoic acids (EETs) that are known to exert protective effects in inflammatory disorders. Endogenous EpFAs are further metabolized into corresponding diols by the soluble epoxide hydrolase (sEH). Through inhibition of sEH, many studies have demonstrated the cardioprotective and renoprotective effects of EpFAs; however, the role of sEH inhibition in modulating the pathogenesis of neuroinflammatory disorders is less well described. In this review, we discuss the current knowledge surrounding the effects of sEH inhibition and EpFA action in neuroinflammatory disorders such as Parkinson's Disease (PD), stroke, depression, epilepsy, and Alzheimer's Disease (AD), as well as the potential mechanisms that underlie the therapeutic effects of sEH inhibition.
Copyright © 2019 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  Alzheimer’s disease (AD); Depression; Epoxyeicosatrienoic acid (EET); Neuroinflammation; Parkinson’s disease (PD); Soluble epoxide hydrolase (sEH); Stroke

Mesh：

Substances：

Year:  2019        PMID： 31698143      PMCID： PMC7067627          DOI： 10.1016/j.prostaglandins.2019.106385

Source DB:  PubMed          Journal:  Prostaglandins Other Lipid Mediat        ISSN： 1098-8823            Impact factor:   3.072


  174 in total

1.  Neurotoxin-induced ER stress in mouse dopaminergic neurons involves downregulation of TRPC1 and inhibition of AKT/mTOR signaling.

Authors:  Senthil Selvaraj; Yuyang Sun; John A Watt; Shouping Wang; Saobo Lei; Lutz Birnbaumer; Brij B Singh
Journal:  J Clin Invest       Date:  2012-03-26       Impact factor: 14.808

2.  Metabolic products of soluble epoxide hydrolase are essential for monocyte chemotaxis to MCP-1 in vitro and in vivo.

Authors:  Suman Kundu; Talat Roome; Ashish Bhattacharjee; Kevin A Carnevale; Valentin P Yakubenko; Renliang Zhang; Sung Hee Hwang; Bruce D Hammock; Martha K Cathcart
Journal:  J Lipid Res       Date:  2012-11-15       Impact factor: 5.922

3.  14,15-epoxyeicosatrienoic Acid suppresses cigarette smoke extract-induced apoptosis in lung epithelial cells by inhibiting endoplasmic reticulum stress.

Authors:  Ganggang Yu; Xiangjun Zeng; Hongxia Wang; Qi Hou; Chunting Tan; Qiufen Xu; Haoyan Wang
Journal:  Cell Physiol Biochem       Date:  2015-05-11

4.  Soluble epoxide hydrolase plays a key role in the pathogenesis of Parkinson's disease.

Authors:  Qian Ren; Min Ma; Jun Yang; Risa Nonaka; Akihiro Yamaguchi; Kei-Ichi Ishikawa; Kenta Kobayashi; Shigeo Murayama; Sung Hee Hwang; Shinji Saiki; Wado Akamatsu; Nobutaka Hattori; Bruce D Hammock; Kenji Hashimoto
Journal:  Proc Natl Acad Sci U S A       Date:  2018-05-07       Impact factor: 11.205

Review 5.  The role of cytochrome P450 enzymes in endogenous signalling pathways and environmental carcinogenesis.

Authors:  Daniel W Nebert; Timothy P Dalton
Journal:  Nat Rev Cancer       Date:  2006-12       Impact factor: 60.716

6.  5-Lipoxygenase gene disruption reduces amyloid-beta pathology in a mouse model of Alzheimer's disease.

Authors:  Omidreza Firuzi; Jiamin Zhuo; Cinzia M Chinnici; Thomas Wisniewski; Domenico Praticò
Journal:  FASEB J       Date:  2007-11-12       Impact factor: 5.191

7.  Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes.

Authors:  Umut Ozcan; Qiong Cao; Erkan Yilmaz; Ann-Hwee Lee; Neal N Iwakoshi; Esra Ozdelen; Gürol Tuncman; Cem Görgün; Laurie H Glimcher; Gökhan S Hotamisligil
Journal:  Science       Date:  2004-10-15       Impact factor: 47.728

Review 8.  The influence of dietary docosahexaenoic acid and arachidonic acid on central nervous system polyunsaturated fatty acid composition.

Authors:  J Thomas Brenna; Guan-Yeu Diau
Journal:  Prostaglandins Leukot Essent Fatty Acids       Date:  2007-11-26       Impact factor: 4.006

Review 9.  Epoxyeicosatrienoic acids (EETs): metabolism and biochemical function.

Authors:  Arthur A Spector; Xiang Fang; Gary D Snyder; Neal L Weintraub
Journal:  Prog Lipid Res       Date:  2004-01       Impact factor: 16.195

10.  Intracellular signaling in the regulation of renal Na-K-ATPase. II. Role of eicosanoids.

Authors:  T Satoh; H T Cohen; A I Katz
Journal:  J Clin Invest       Date:  1993-02       Impact factor: 14.808
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  16 in total

1.  Designing a Small Fluorescent Inhibitor to Investigate Soluble Epoxide Hydrolase Engagement in Living Cells.

Authors:  Steffen Brunst; Julia Schönfeld; Peter Breunig; Luisa D Burgers; Murphy DeMeglio; Johanna H M Ehrler; Felix F Lillich; Lilia Weizel; Jasmin K Hefendehl; Robert Fürst; Ewgenij Proschak; Kerstin Hiesinger
Journal:  ACS Med Chem Lett       Date:  2022-06-14       Impact factor: 4.632

2.  The epoxy fatty acid pathway enhances cAMP in mammalian cells through multiple mechanisms.

Authors:  Naoki Matsumoto; Nalin Singh; Kin Sing Lee; Bogdan Barnych; Christophe Morisseau; Bruce D Hammock
Journal:  Prostaglandins Other Lipid Mediat       Date:  2022-06-30       Impact factor: 3.813

Review 3.  Soluble Epoxide Hydrolase as a Therapeutic Target for Neuropsychiatric Disorders.

Authors:  Jiajing Shan; Kenji Hashimoto
Journal:  Int J Mol Sci       Date:  2022-04-29       Impact factor: 6.208

4.  Maternal glyphosate exposure causes autism-like behaviors in offspring through increased expression of soluble epoxide hydrolase.

Authors:  Yaoyu Pu; Jun Yang; Lijia Chang; Youge Qu; Siming Wang; Kai Zhang; Zhongwei Xiong; Jiancheng Zhang; Yunfei Tan; Xingming Wang; Yuko Fujita; Tamaki Ishima; Debin Wang; Sung Hee Hwang; Bruce D Hammock; Kenji Hashimoto
Journal:  Proc Natl Acad Sci U S A       Date:  2020-05-12       Impact factor: 11.205

Review 5.  Epoxy Fatty Acids Are Promising Targets for Treatment of Pain, Cardiovascular Disease and Other Indications Characterized by Mitochondrial Dysfunction, Endoplasmic Stress and Inflammation.

Authors:  Cindy McReynolds; Christophe Morisseau; Karen Wagner; Bruce Hammock
Journal:  Adv Exp Med Biol       Date:  2020       Impact factor: 2.622

6.  A Distinct Metabolically Defined Central Nucleus Circuit Bidirectionally Controls Anxiety-Related Behaviors.

Authors:  Jing Ren; Cheng-Lin Lu; Jie Huang; Jun Fan; Fang Guo; Jia-Wen Mo; Wei-Yuan Huang; Peng-Li Kong; Xiao-Wen Li; Li-Rong Sun; Xiang-Dong Sun; Xiong Cao
Journal:  J Neurosci       Date:  2022-02-01       Impact factor: 6.709

Review 7.  Soluble Epoxide Hydrolase Inhibition to Face Neuroinflammation in Parkinson's Disease: A New Therapeutic Strategy.

Authors:  Mercè Pallàs; Santiago Vázquez; Coral Sanfeliu; Carles Galdeano; Christian Griñán-Ferré
Journal:  Biomolecules       Date:  2020-05-01

8.  Ingestion of Faecalibaculum rodentium causes depression-like phenotypes in resilient Ephx2 knock-out mice: A role of brain-gut-microbiota axis via the subdiaphragmatic vagus nerve.

Authors:  Siming Wang; Tamaki Ishima; Youge Qu; Jiajing Shan; Lijia Chang; Yan Wei; Jiancheng Zhang; Yaoyu Pu; Yuko Fujita; Yunfei Tan; Xingming Wang; Li Ma; Xiayun Wan; Bruce D Hammock; Kenji Hashimoto
Journal:  J Affect Disord       Date:  2021-06-11       Impact factor: 6.533

9.  The Impact of Nutrition and Intestinal Microbiome on Elderly Depression-A Systematic Review.

Authors:  Blanka Klimova; Michal Novotny; Martin Valis
Journal:  Nutrients       Date:  2020-03-07       Impact factor: 5.717

Review 10.  Cytochrome P450 Metabolism of Polyunsaturated Fatty Acids and Neurodegeneration.

Authors:  Morteza Sarparast; Devon Dattmore; Jamie Alan; Kin Sing Stephen Lee
Journal:  Nutrients       Date:  2020-11-16       Impact factor: 5.717
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