Literature DB >> 31697892

Neisseria gonorrhoeae Becomes Susceptible to Polymyxin B and Colistin in the Presence of PBT2.

Freda E-C Jen1, Arun V Everest-Dass1, Ibrahim M El-Deeb1, Sanjesh Singh1, Thomas Haselhorst1, Mark J Walker2, Mark von Itzstein1, Michael P Jennings1.   

Abstract

Neisseria gonorrhoeae (N. gonorrhoeae) causes the sexually transmitted disease gonorrhea, which has a global incidence of 106 million cases per year. No vaccine is available to prevent the disease, and the emergence of multidrug resistant (MDR) strains makes N. gonorrhoeae an immediate public health threat. Here, we show that an ionophore, PBT2, can reverse the intrinsic resistance of N. gonorrhoeae to polymyxin B and colistin. These antibiotics administered in combination with PBT2 may be an effective path to treat MDR gonococcal infections.

Entities:  

Keywords:  Gram-negative bacteria; PBT2; colistin; multidrug resistant Neisseria gonorrhoeae; polymyxin B; synergy

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Substances：

Year:  2019        PMID： 31697892     DOI： 10.1021/acsinfecdis.9b00307

Source DB:  PubMed          Journal:  ACS Infect Dis        ISSN： 2373-8227            Impact factor:   5.084


  5 in total

Review 1.  Antimicrobial Resistance in ESKAPE Pathogens.

Authors:  David M P De Oliveira; Brian M Forde; Timothy J Kidd; Patrick N A Harris; Mark A Schembri; Scott A Beatson; David L Paterson; Mark J Walker
Journal:  Clin Microbiol Rev       Date:  2020-05-13       Impact factor: 26.132

2.  Repurposing the Ionophore, PBT2, for Treatment of Multidrug-Resistant Neisseria gonorrhoeae Infections.

Authors:  Freda E-C Jen; Jennifer L Edwards; Ibrahim M El-Deeb; Mark J Walker; Mark von Itzstein; Michael P Jennings
Journal:  Antimicrob Agents Chemother       Date:  2022-08-18       Impact factor: 5.938

3.  Transcriptomic Data Sets To Determine Gene Expression Changes Mediated by the Presence of PBT2 in Growth Medium of Multidrug-Resistant Neisseria gonorrhoeae WHO Z.

Authors:  Freda E-C Jen; Ibrahim M El-Deeb; John M Atack; Mark von Itzstein; Michael P Jennings
Journal:  Microbiol Resour Announc       Date:  2020-05-21

4.  Rescuing Tetracycline Class Antibiotics for the Treatment of Multidrug-Resistant Acinetobacter baumannii Pulmonary Infection.

Authors:  David M P De Oliveira; Brian M Forde; Minh-Duy Phan; Bernhard Steiner; Bing Zhang; Johannes Zuegg; Ibrahim M El-Deeb; Gen Li; Nadia Keller; Stephan Brouwer; Nichaela Harbison-Price; Amanda J Cork; Michelle J Bauer; Saleh F Alquethamy; Scott A Beatson; Jason A Roberts; David L Paterson; Alastair G McEwan; Mark A T Blaskovich; Mark A Schembri; Christopher A McDevitt; Mark von Itzstein; Mark J Walker
Journal:  mBio       Date:  2022-01-11       Impact factor: 7.867

5.  Dysregulation of Streptococcus pneumoniae zinc homeostasis breaks ampicillin resistance in a pneumonia infection model.

Authors:  Erin B Brazel; Aimee Tan; Stephanie L Neville; Amy R Iverson; Saumya R Udagedara; Bliss A Cunningham; Mwilye Sikanyika; David M P De Oliveira; Bernhard Keller; Lisa Bohlmann; Ibrahim M El-Deeb; Katherine Ganio; Bart A Eijkelkamp; Alastair G McEwan; Mark von Itzstein; Megan J Maher; Mark J Walker; Jason W Rosch; Christopher A McDevitt
Journal:  Cell Rep       Date:  2022-01-11       Impact factor: 9.995
  5 in total

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