Literature DB >> 35980187

Repurposing the Ionophore, PBT2, for Treatment of Multidrug-Resistant Neisseria gonorrhoeae Infections.

Freda E-C Jen1, Jennifer L Edwards2, Ibrahim M El-Deeb1, Mark J Walker3, Mark von Itzstein1, Michael P Jennings1.   

Abstract

Multidrug-resistant (MDR) N. gonorrhoeae is a current public health threat. New therapies are urgently needed. PBT2 is an ionophore that disrupts metal homeostasis. PBT2 administered with zinc is shown to reverse resistance to antibiotics in several bacterial pathogens. Here we show that both N. meningitidis and MDR N. gonorrhoeae are sensitive to killing by PBT2 alone. PBT2 is, thus, a candidate therapeutic for MDR N. gonorrhoeae infections.

Entities:  

Keywords:  Neisseria gonorrhoeae; Neisseria meningitidis; PBT2; antibiotic resistance; gonorrhoea; ionophore

Mesh：

Substances：

Year:  2022        PMID： 35980187      PMCID： PMC9487457          DOI： 10.1128/aac.02318-21

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.938


  22 in total

Review 1.  Antibacterial resistance worldwide: causes, challenges and responses.

Authors:  Stuart B Levy; Bonnie Marshall
Journal:  Nat Med       Date:  2004-12       Impact factor: 53.440

2.  Regulation of mtrF expression in Neisseria gonorrhoeae and its role in high-level antimicrobial resistance.

Authors:  Jason P Folster; William M Shafer
Journal:  J Bacteriol       Date:  2005-06       Impact factor: 3.490

3.  Copper(II) Binding to PBT2 Differs from That of Other 8-Hydroxyquinoline Chelators: Implications for the Treatment of Neurodegenerative Protein Misfolding Diseases.

Authors:  Kelly L Summers; Graham P Roseman; George J Sopasis; Glenn L Millhauser; Hugh H Harris; Ingrid J Pickering; Graham N George
Journal:  Inorg Chem       Date:  2020-11-23       Impact factor: 5.165

4.  Safety, tolerability, and efficacy of PBT2 in Huntington's disease: a phase 2, randomised, double-blind, placebo-controlled trial.

Authors: 
Journal:  Lancet Neurol       Date:  2014-11-14       Impact factor: 44.182

5.  Repurposing a neurodegenerative disease drug to treat Gram-negative antibiotic-resistant bacterial sepsis.

Authors:  David M P De Oliveira; Lisa Bohlmann; Trent Conroy; Freda E-C Jen; Arun Everest-Dass; Karl A Hansford; Raghu Bolisetti; Ibrahim M El-Deeb; Brian M Forde; Minh-Duy Phan; Jake A Lacey; Aimee Tan; Tania Rivera-Hernandez; Stephan Brouwer; Nadia Keller; Timothy J Kidd; Amanda J Cork; Michelle J Bauer; Gregory M Cook; Mark R Davies; Scott A Beatson; David L Paterson; Alastair G McEwan; Jian Li; Mark A Schembri; Mark A T Blaskovich; Michael P Jennings; Christopher A McDevitt; Mark von Itzstein; Mark J Walker
Journal:  Sci Transl Med       Date:  2020-11-18       Impact factor: 17.956

6.  Recombinant truncated AniA of pathogenic Neisseria elicits a non-native immune response and functional blocking antibodies.

Authors:  Lucy K Shewell; Shan C Ku; Benjamin L Schulz; Freda E-C Jen; Tsitsi D Mubaiwa; Margaret R Ketterer; Michael A Apicella; Michael P Jennings
Journal:  Biochem Biophys Res Commun       Date:  2013-01-09       Impact factor: 3.575

7.  Phenotypic and genetic characterization of the 2008 WHO Neisseria gonorrhoeae reference strain panel intended for global quality assurance and quality control of gonococcal antimicrobial resistance surveillance for public health purposes.

Authors:  Magnus Unemo; Oskar Fasth; Hans Fredlund; Athena Limnios; John Tapsall
Journal:  J Antimicrob Chemother       Date:  2009-03-24       Impact factor: 5.790

8.  Transcriptomic Data Sets To Determine Gene Expression Changes Mediated by the Presence of PBT2 in Growth Medium of Multidrug-Resistant Neisseria gonorrhoeae WHO Z.

Authors:  Freda E-C Jen; Ibrahim M El-Deeb; John M Atack; Mark von Itzstein; Michael P Jennings
Journal:  Microbiol Resour Announc       Date:  2020-05-21

9.  Detection of Ciprofloxacin-Resistant, β-Lactamase-Producing Neisseria meningitidis Serogroup Y Isolates - United States, 2019-2020.

Authors:  Lucy A McNamara; Caelin Potts; Amy E Blain; Adam C Retchless; Natashia Reese; Stephanie Swint; David Lonsway; Maria Karlsson; Kristy Lunquest; John J Sweitzer; Xin Wang; Susan Hariri; LeAnne M Fox
Journal:  MMWR Morb Mortal Wkly Rep       Date:  2020-06-19       Impact factor: 17.586

Review 10.  Zinc transporters in Alzheimer's disease.

Authors:  Yingshuo Xu; Guiran Xiao; Li Liu; Minglin Lang
Journal:  Mol Brain       Date:  2019-12-09       Impact factor: 4.041
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