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Literature DB >> 31693723

Nucleoli and Promyelocytic Leukemia Protein (PML) bodies are phase separated nuclear protein quality control compartments for misfolded proteins.

L Mediani¹, J Guillén-Boixet², S Alberti^2,3, S Carra¹.

Abstract

We uncovered a role for nucleoli and PML-bodies as phase-separated protein quality control organelles that compartmentalize protein quality control factors and misfolded proteins for their efficient clearance. Failure to dispose misfolded proteins converts nucleoli and PML-bodies into a solid state that immobilizes ubiquitin, limiting its recycling for genome integrity maintenance.

Entities: Gene

Keywords: Protein quality control; genome instability; membraneless organelles; nucleus

Year: 2019 PMID： 31693723 PMCID： PMC6816371 DOI： 10.1080/23723556.2019.1652519

Source DB: PubMed Journal: Mol Cell Oncol ISSN： 2372-3556

10 in total

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