Feeha Azeem1, Romella Durrani1,2, Charlotte Zerna1,2,3,4, Eric E Smith5,6,7,8. 1. Neurology, Department of Clinical Neurosciences, University of Calgary, 3330 Hospital Drive NW, Calgary, AB, T2N 4N1, Canada. 2. Hotchkiss Brain Institute, Calgary, AB, Canada. 3. Calgary Stroke Program, Calgary, AB, Canada. 4. Department of Community Health Sciences, University of Calgary, Calgary, AB, Canada. 5. Neurology, Department of Clinical Neurosciences, University of Calgary, 3330 Hospital Drive NW, Calgary, AB, T2N 4N1, Canada. eesmith@ucalgary.ca. 6. Hotchkiss Brain Institute, Calgary, AB, Canada. eesmith@ucalgary.ca. 7. Calgary Stroke Program, Calgary, AB, Canada. eesmith@ucalgary.ca. 8. Department of Community Health Sciences, University of Calgary, Calgary, AB, Canada. eesmith@ucalgary.ca.
Abstract
BACKGROUND: Silent brain infarction (SBI) may be associated with cognitive decline in the general population. We systematically reviewed prior literature on: (1) SBI and cognition cross-sectionally; (2) baseline SBI and future cognitive decline and risk for cognitive disorders including dementia, and (3) incident SBI and the emergence of cognitive decline or cognitive disorders. METHODS: The MEDLINE and EMBASE databases were searched for relevant studies. Data were independently extracted by two reviewers. Quality was assessed using the Newcastle Ottawa Scale. Data were pooled using a random effects model when more than two comparable estimates were found. RESULTS: Thirty relevant studies were identified: 17 had a cross-sectional design, 10 evaluated the association of baseline SBI with future cognitive decline, and 5 evaluated the association of incident SBI with cognitive decline. Most cross-sectional studies reported lower cognitive performance in persons with SBI. The pooled risk for incident dementia in persons with SBI was 1.48 (95% CI 1.12-1.97), but there was significant heterogeneity (p = 0.009); removing one outlier eliminated the heterogeneity (p = 0.53), giving a lower but still significant estimate (hazard ratio 1.27, 95% CI 1.06-1.51). The pooled risk for incident MCI was not increased in persons with SBI (hazard ratio 0.83, 95% CI 0.40 to 1.72), but there was significant heterogeneity (p < 0.001). The appearance of new SBI was associated with steeper rate of cognitive decline and the appearance of dementia. CONCLUSIONS: SBI are associated with worse cognition and increased risk for dementia. More standardization of cognitive assessment methods would facilitate future cross-study comparisons.
BACKGROUND:Silent brain infarction (SBI) may be associated with cognitive decline in the general population. We systematically reviewed prior literature on: (1) SBI and cognition cross-sectionally; (2) baseline SBI and future cognitive decline and risk for cognitive disorders including dementia, and (3) incident SBI and the emergence of cognitive decline or cognitive disorders. METHODS: The MEDLINE and EMBASE databases were searched for relevant studies. Data were independently extracted by two reviewers. Quality was assessed using the Newcastle Ottawa Scale. Data were pooled using a random effects model when more than two comparable estimates were found. RESULTS: Thirty relevant studies were identified: 17 had a cross-sectional design, 10 evaluated the association of baseline SBI with future cognitive decline, and 5 evaluated the association of incident SBI with cognitive decline. Most cross-sectional studies reported lower cognitive performance in persons with SBI. The pooled risk for incident dementia in persons with SBI was 1.48 (95% CI 1.12-1.97), but there was significant heterogeneity (p = 0.009); removing one outlier eliminated the heterogeneity (p = 0.53), giving a lower but still significant estimate (hazard ratio 1.27, 95% CI 1.06-1.51). The pooled risk for incident MCI was not increased in persons with SBI (hazard ratio 0.83, 95% CI 0.40 to 1.72), but there was significant heterogeneity (p < 0.001). The appearance of new SBI was associated with steeper rate of cognitive decline and the appearance of dementia. CONCLUSIONS:SBI are associated with worse cognition and increased risk for dementia. More standardization of cognitive assessment methods would facilitate future cross-study comparisons.
Entities:
Keywords:
Dementia; Magnetic resonance imaging; Mild cognitive impairment; Stroke
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