Katherine J Bangen1,2, Sarah R Preis3,4, Lisa Delano-Wood1,2, Philip A Wolf3,5, David J Libon6, Mark W Bondi1,2, Rhoda Au3,5, Charles DeCarli7, Adam M Brickman8,9,10. 1. VA San Diego Healthcare System. 2. Department of Psychiatry, University of California, San Diego, San Diego. 3. Framingham Heart Study, Framingham. 4. Department of Biostatistics, Boston University School of Public Health. 5. Department of Neurology, Boston University School of Medicine, Boston, MA. 6. Departments of Geriatrics and Gerontology and the Department of Psychology, New Institute for Successful Aging, School of Osteopathic Medicine, Rowan University, Stratford, NJ. 7. Department of Neurology and Center for Neuroscience, University of California at Davis, Sacramento, CA. 8. Taub Institute for Research on Alzheimer's Disease and the Aging Brain. 9. Gertrude H. Sergievsky Center. 10. Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY.
Abstract
INTRODUCTION: We examined associations between magnetic resonance imaging (MRI) markers of cerebrovascular disease and neurodegeneration with mild cognitive impairment (MCI) diagnosis at baseline and conversion from normal cognition to MCI at follow-up. METHODS: Framingham Offspring participants underwent brain MRI and neuropsychological assessment at baseline (n=1049) and follow-up (n=561). Participants were classified at baseline and at follow-up as cognitively normal or MCI using sensitive neuropsychological criteria. White matter hyperintensity (WMH) volume, covert brain infarcts, hippocampal volume, and total cerebral brain volume were quantified. RESULTS: Baseline measures of WMH and hippocampal volume were associated with MCI status cross-sectionally and also with conversion from normal cognition to MCI at 6.5-year follow-up. Annualized change rates in total cerebral brain volume and hippocampal volume were associated with conversion from normal cognition to MCI to follow-up. DISCUSSION: Baseline WMH and hippocampal volume are markers that are both associated with conversion from normal cognition to MCI, highlighting the role of both vascular lesions and neurodegeneration in MCI.
INTRODUCTION: We examined associations between magnetic resonance imaging (MRI) markers of cerebrovascular disease and neurodegeneration with mild cognitive impairment (MCI) diagnosis at baseline and conversion from normal cognition to MCI at follow-up. METHODS: Framingham Offspring participants underwent brain MRI and neuropsychological assessment at baseline (n=1049) and follow-up (n=561). Participants were classified at baseline and at follow-up as cognitively normal or MCI using sensitive neuropsychological criteria. White matter hyperintensity (WMH) volume, covert brain infarcts, hippocampal volume, and total cerebral brain volume were quantified. RESULTS: Baseline measures of WMH and hippocampal volume were associated with MCI status cross-sectionally and also with conversion from normal cognition to MCI at 6.5-year follow-up. Annualized change rates in total cerebral brain volume and hippocampal volume were associated with conversion from normal cognition to MCI to follow-up. DISCUSSION: Baseline WMH and hippocampal volume are markers that are both associated with conversion from normal cognition to MCI, highlighting the role of both vascular lesions and neurodegeneration in MCI.
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