Ganesh M Babulal1,2, Sarah H Stout3,4, Monique M Williams5, Ganesh Rajasekar3,4, Annie Harmon6, Jonathon Vivoda7, Megan Zuelsdorff8, Tammie L S Benzinger3,9,10, John C Morris3,4,9,11,12,13,14, Beau Ances3,4,11, Catherine M Roe3,4. 1. Charles F. and Joanne Knight Alzheimer's Disease Research Center, 660 S. Euclid Ave., Campus Box, St. Louis, MO, 8111, USA. babulalg@wustl.edu. 2. Department of Neurology, Washington University, St. Louis, MO, USA. babulalg@wustl.edu. 3. Charles F. and Joanne Knight Alzheimer's Disease Research Center, 660 S. Euclid Ave., Campus Box, St. Louis, MO, 8111, USA. 4. Department of Neurology, Washington University, St. Louis, MO, USA. 5. BJC Medical Group, St. Louis, MO, USA. 6. Department of Medicine, Washington University, St. Louis, MO, USA. 7. Miami University, Oxford, OH, USA. 8. University of Wisconsin, Madison, WI, USA. 9. Department of Radiology, Washington University, St. Louis, MO, USA. 10. Department of Neurosurgery, Washington University, St. Louis, MO, USA. 11. Hope Center for Neurological Disorders, Washington University, St. Louis, MO, USA. 12. Department of Pathology and Immunology, Washington University, St. Louis, MO, USA. 13. Department of Physical Therapy, Washington University, St. Louis, MO, USA. 14. Department of Occupational Therapy, Washington University, St. Louis, MO, USA.
Abstract
OBJECTIVE: To examine the effect of race in driving performance and behavior prospectively among cognitively normal older adults. METHODS: Cognitively normal participants (Clinical Dementia Rating 0), ≥ 65 years of age (n = 177) were selected from prospective, longitudinal studies at the Knight Alzheimer Disease Research Center at Washington University. Self-reported driving behavior (Driving Habits Questionnaire) and driving performance (road test) were annually assessed. Daily driving behavior data were collected using the Driving Real World In-Vehicle Evaluation System (DRIVES). Baseline differences between African Americans and Caucasians were tested using t tests and general linear models. Amyloid imaging and cerebrospinal fluid Alzheimer disease (AD) biomarkers were compared across groups. Linear mixed models examined change in daily driving behavior over time. Survival analyses tested time to a marginal or fail rating on the road test. RESULTS: There were no differences between African Americans (n = 34) and Caucasians (n = 143) in age, sex, education, or vascular risk factors. Baseline self-reported driving behavior and road test performance were largely similar for both races. Longitudinal analyses using the DRIVES data aggregated monthly showed that African Americans had a greater reduction in number of trips made per month, miles driven per month, and trips with aggressive behavior compared to Caucasians. These effects remained after controlling for AD biomarkers, age, education, and sex. CONCLUSIONS: In this sample of cognitively normal older adults, African Americans had a greater reduction of daily driving behavior compared to Caucasians. Observed racial differences may reflect differences in environmental/social factors, changes in cognition, and/or physical functioning.
OBJECTIVE: To examine the effect of race in driving performance and behavior prospectively among cognitively normal older adults. METHODS: Cognitively normal participants (Clinical Dementia Rating 0), ≥ 65 years of age (n = 177) were selected from prospective, longitudinal studies at the Knight Alzheimer Disease Research Center at Washington University. Self-reported driving behavior (Driving Habits Questionnaire) and driving performance (road test) were annually assessed. Daily driving behavior data were collected using the Driving Real World In-Vehicle Evaluation System (DRIVES). Baseline differences between African Americans and Caucasians were tested using t tests and general linear models. Amyloid imaging and cerebrospinal fluid Alzheimer disease (AD) biomarkers were compared across groups. Linear mixed models examined change in daily driving behavior over time. Survival analyses tested time to a marginal or fail rating on the road test. RESULTS: There were no differences between African Americans (n = 34) and Caucasians (n = 143) in age, sex, education, or vascular risk factors. Baseline self-reported driving behavior and road test performance were largely similar for both races. Longitudinal analyses using the DRIVES data aggregated monthly showed that African Americans had a greater reduction in number of trips made per month, miles driven per month, and trips with aggressive behavior compared to Caucasians. These effects remained after controlling for AD biomarkers, age, education, and sex. CONCLUSIONS: In this sample of cognitively normal older adults, African Americans had a greater reduction of daily driving behavior compared to Caucasians. Observed racial differences may reflect differences in environmental/social factors, changes in cognition, and/or physical functioning.
Authors: Anne E Dickerson; Lisa J Molnar; Michel Bédard; David W Eby; Marla Berg-Weger; Moon Choi; Jenai Grigg; Amy Horowitz; Thomas Meuser; Anita Myers; Melissa O'Connor; Nina M Silverstein Journal: Gerontologist Date: 2019-03-14
Authors: Ganesh M Babulal; Sarah H Stout; Tammie L S Benzinger; Brian R Ott; David B Carr; Mollie Webb; Cindy M Traub; Aaron Addison; John C Morris; David K Warren; Catherine M Roe Journal: J Appl Gerontol Date: 2017-01-29
Authors: Jennifer C Howell; Kelly D Watts; Monica W Parker; Junjie Wu; Alexander Kollhoff; Thomas S Wingo; Cornelya D Dorbin; Deqiang Qiu; William T Hu Journal: Alzheimers Res Ther Date: 2017-11-02 Impact factor: 6.982
Authors: Catherine M Roe; Sayeh Bayet; Jamie Hicks; Ann M Johnson; Samantha Murphy; Jason M Doherty; Ganesh M Babulal Journal: J Appl Gerontol Date: 2022-05-11