| Literature DB >> 31682416 |
Xiaozhen Li1, Lu Liu2, Shengliang Li1, Yingpeng Wan1, Jia-Xiong Chen1,3, Shuang Tian1, Zhongming Huang1, Ya-Fang Xiao1, Xiao Cui1, Chengyang Xiang4, Qinglong Tan4, Xiao-Hong Zhang3, Weisheng Guo4, Xing-Jie Liang2, Chun-Sing Lee1.
Abstract
We developed a biodegradable photothermal therapeutic (PTT) agent, π-conjugated oligomer nanoparticles (F8-PEG NPs), for highly efficient cancer theranostics. By exploiting an oligomer with excellent near-infrared (NIR) absorption, the nanoparticles show a high photothermal conversion efficiency (PCE) up to 82%, surpassing those of reported inorganic and organic PTT agents. In addition, the oligomer nanoparticles show excellent photostability and good biodegradability. The F8-PEG NPs are also demonstrated to have excellent biosafety and PTT efficacy both in vitro and in vivo. This contribution not only proposes a promising oligomer-based PTT agent but also provides insight into developing highly efficient nanomaterials for cancer theranostics.Entities:
Keywords: biodegradability; conjugated oligomer; nanoparticle; photothermal conversion efficiency; photothermal therapy
Mesh：
Year: 2019 PMID： 31682416 DOI： 10.1021/acsnano.9b05383
Source DB: PubMed Journal: ACS Nano ISSN： 1936-0851 Impact factor: 15.881