Marta Martin-Subero1,2,3, Paola Fuentes-Claramonte1,2, Pilar Salgado-Pineda1,2, Josep Salavert1,3,4, Antoni Arevalo1,5, Clara Bosque1,6, Carmen Sarri1,6, Amalia Guerrero-Pedraza1,6, Aniol Santo-Angles1, Antoni Capdevila7,8, Salvador Sarró1,2, Raymond Salvador1,2, Peter J McKenna1,2, Edith Pomarol-Clotet1,2. 1. FIDMAG Germanes Hospitalàries Research Foundation, Barcelona, Spain. 2. CIBERSAM (Centro de Investigación Biomédica en Red de Salud Mental), Madrid, Spain. 3. Department of Psychiatry and Forensic Medicine, Universitat Autònoma de Barcelona, Barcelona, Spain. 4. Psychiatry Department, Hospital Sant Rafael, Barcelona, Spain. 5. Psychiatry Department, Hospital Sagrat Cor Martorell Barcelona, Barcelona, Spain. 6. Benito Menni Centre Assistencial en Salut Mental, Sant Boi de Llobregat, Barcelona, Spain. 7. Radiology Unit, Hospital de la Santa Creu i Sant Pau (HSCSP), Barcelona, Spain. 8. CIBER-BBN (Centro de Investigación Biomédica en Red en Bioingeniería, Biomateriales y Nanomedicina), Zaragoza, Spain.
Abstract
BACKGROUND: The brain functional correlates of autobiographical recall are well established, but have been little studied in schizophrenia. Additionally, autobiographical memory is one of a small number of cognitive tasks that activates rather than de-activates the default mode network, which has been found to be dysfunctional in this disorder. METHODS: Twenty-seven schizophrenic patients and 30 healthy controls underwent functional magnetic resonance imaging while viewing cue words that evoked autobiographical memories. Control conditions included both non-memory-evoking cues and a low level baseline (cross fixation). RESULTS: Compared to both non-memory evoking cues and low level baseline, autobiographical recall was associated with activation in default mode network regions in the controls including the medial frontal cortex, the posterior cingulate cortex and the hippocampus, as well as other areas. Clusters of de-activation were seen outside the default mode network. There were no activation differences between the schizophrenic patients and the controls, but the patients showed clusters of failure of de-activation in non-default mode network regions. CONCLUSIONS: According to this study, patients with schizophrenia show intact activation of the default mode network and other regions associated with recall of autobiographical memories. The finding of failure of de-activation outside the network suggests that schizophrenia may be associated with a general difficulty in de-activation rather than dysfunction of the default mode network per se.
BACKGROUND: The brain functional correlates of autobiographical recall are well established, but have been little studied in schizophrenia. Additionally, autobiographical memory is one of a small number of cognitive tasks that activates rather than de-activates the default mode network, which has been found to be dysfunctional in this disorder. METHODS: Twenty-seven schizophrenicpatients and 30 healthy controls underwent functional magnetic resonance imaging while viewing cue words that evoked autobiographical memories. Control conditions included both non-memory-evoking cues and a low level baseline (cross fixation). RESULTS: Compared to both non-memory evoking cues and low level baseline, autobiographical recall was associated with activation in default mode network regions in the controls including the medial frontal cortex, the posterior cingulate cortex and the hippocampus, as well as other areas. Clusters of de-activation were seen outside the default mode network. There were no activation differences between the schizophrenicpatients and the controls, but the patients showed clusters of failure of de-activation in non-default mode network regions. CONCLUSIONS: According to this study, patients with schizophrenia show intact activation of the default mode network and other regions associated with recall of autobiographical memories. The finding of failure of de-activation outside the network suggests that schizophrenia may be associated with a general difficulty in de-activation rather than dysfunction of the default mode network per se.
Authors: Michael D Fox; Abraham Z Snyder; Justin L Vincent; Maurizio Corbetta; David C Van Essen; Marcus E Raichle Journal: Proc Natl Acad Sci U S A Date: 2005-06-23 Impact factor: 11.205
Authors: Fabien C Schneider; Aurélie Royer; Anne Grosselin; Jacques Pellet; Fabrice-Guy Barral; Bernard Laurent; Denis Brouillet; François Lang Journal: Schizophr Res Date: 2010-12-13 Impact factor: 4.939
Authors: Marta Martin-Subero; Paola Fuentes-Claramonte; Pilar Salgado-Pineda; Josep Salavert; Antoni Arevalo; Clara Bosque; Carmen Sarri; Amalia Guerrero-Pedraza; Aniol Santo-Angles; Antoni Capdevila; Salvador Sarró; Raymond Salvador; Peter J McKenna; Edith Pomarol-Clotet Journal: Psychol Med Date: 2020-05-07 Impact factor: 7.723