BACKGROUND: Autobiographical memory retrieval is impaired in schizophrenia. AIMS: To determine the neural basis of this impairment. METHOD: Thirteen patients with schizophrenia and 14 healthy controls performed an autobiographical memory retrieval task based on cue words during functional magnetic resonance imaging. Patients were selected on the basis of their ability to perform the task and all participants received training. RESULTS: Although patients and controls activated a similar brain network during autobiographical memory retrieval, patients displayed decreased activation in several of these regions, including the anterior cingulate cortex, left lateral prefrontal cortex, right cerebellum and ventral tegmental area (k≥10, P<0.001, uncorrected). In addition, activation of the caudate nuclei was negatively correlated with retrieval performance in controls but positively correlated with performance in patients. CONCLUSIONS: The autobiographical memory retrieval brain network is impaired in schizophrenia. Patients with schizophrenia display decreased activation of the cognitive control network during retrieval, possibly due to aberrant functioning of the dorsal striatum.
BACKGROUND: Autobiographical memory retrieval is impaired in schizophrenia. AIMS: To determine the neural basis of this impairment. METHOD: Thirteen patients with schizophrenia and 14 healthy controls performed an autobiographical memory retrieval task based on cue words during functional magnetic resonance imaging. Patients were selected on the basis of their ability to perform the task and all participants received training. RESULTS: Although patients and controls activated a similar brain network during autobiographical memory retrieval, patients displayed decreased activation in several of these regions, including the anterior cingulate cortex, left lateral prefrontal cortex, right cerebellum and ventral tegmental area (k≥10, P<0.001, uncorrected). In addition, activation of the caudate nuclei was negatively correlated with retrieval performance in controls but positively correlated with performance in patients. CONCLUSIONS: The autobiographical memory retrieval brain network is impaired in schizophrenia. Patients with schizophrenia display decreased activation of the cognitive control network during retrieval, possibly due to aberrant functioning of the dorsal striatum.
Authors: Romane Dassing; Mélissa C Allé; Mathieu Cerbai; Alexandre Obrecht; Nicolas Meyer; Pierre Vidailhet; Jean-Marie Danion; Amaury C Mengin; Fabrice Berna Journal: Front Psychiatry Date: 2020-05-08 Impact factor: 4.157
Authors: Marta Martin-Subero; Paola Fuentes-Claramonte; Pilar Salgado-Pineda; Josep Salavert; Antoni Arevalo; Clara Bosque; Carmen Sarri; Amalia Guerrero-Pedraza; Aniol Santo-Angles; Antoni Capdevila; Salvador Sarró; Raymond Salvador; Peter J McKenna; Edith Pomarol-Clotet Journal: Psychol Med Date: 2019-11-04 Impact factor: 7.723
Authors: Irene Y Huang; Yu-Luan Hsu; Chien-Chang Chen; Mei-Fang Chen; Zhi-Hong Wen; Hsien-Ting Huang; Ingrid Y Liu Journal: Mar Drugs Date: 2018-10-25 Impact factor: 5.118