Federico M Asch1, Tatsuya Miyoshi2, Karima Addetia3, Rodolfo Citro4, Masao Daimon5, Sameer Desale2, Pedro Gutierrez Fajardo6, Ravi R Kasliwal7, James N Kirkpatrick8, Mark J Monaghan9, Denisa Muraru10, Kofo O Ogunyankin11, Seung Woo Park12, Ricardo E Ronderos13, Anita Sadeghpour14, Gregory M Scalia15, Masaaki Takeuchi16, Wendy Tsang17, Edwin S Tucay18, Ana Clara Tude Rodrigues19, Amuthan Vivekanandan20, Yun Zhang21, Alexandra Blitz22, Roberto M Lang3. 1. MedStar Health Research Institute, Washington, District of Columbia. Electronic address: federico.asch@medstar.net. 2. MedStar Health Research Institute, Washington, District of Columbia. 3. University of Chicago, Chicago, Illinois. 4. University of Salerno, Salerno, Italy. 5. University of Tokyo, Tokyo, Japan. 6. Hospital Bernardette, Guadalajara, Mexico. 7. Medanta Medicity, Gurgaon, India. 8. University of Washington, Seattle, Washington. 9. King's College Hospital, London, United Kingdom. 10. University of Padua, Padua, Italy. 11. First Cardiology Consultants Hospital Ikoyi, Lagos, Nigeria. 12. Samsung Medical Center/Sungkyunkwan University School of Medicine, Seoul, Korea. 13. Instituto Cardiovascular de Buenos Aires, Buenos Aires, Argentina. 14. Rajaie Cardiovascular Medical and Center, Echocardiography Research Center, IUMS, Tehran, Iran. 15. GenesisCare, Brisbane, Australia. 16. University of Occupational and Environmental Health, Kitakyushu, Japan. 17. Toronto General Hospital/University of Toronto, Toronto, Ontario, Canada. 18. Philippine Heart Center, Quezon City, Philippines. 19. Hospital Israelita Albert Einstein, São Paulo, Brazil. 20. Jeyalakshmi Heart Center, Madurai, India. 21. Qilu Hospital of Shandong University, Jinan, Shandong, China. 22. TomTec Imaging Systems, Unterschleissheim, Germany.
Abstract
BACKGROUND: The World Alliance Societies of Echocardiography (WASE) Normal Values Study evaluates individuals from multiple countries and races with the aim of describing normative values that could be applied to the global community worldwide and to determine differences and similarities among people from different countries and races. The present report focuses specifically on two-dimensional (2D) left ventricular (LV) dimensions, volumes, and systolic function. METHODS: The WASE Normal Values Study is a multicenter international, observational, prospective, cross-sectional study of healthy adult individuals. Participants recruited in each country were evenly distributed among six predetermined subgroups according to age and gender. Comprehensive 2D transthoracic echocardiograms were acquired and analyzed following strict protocols based on recent American Society of Echocardiography and European Association of Cardiovascular Imaging guidelines. Analysis was performed at the WASE 2D core laboratory and included 2D LV dimensions, LV volumes, and LV ejection fraction (LVEF) by the biplane Simpson method and global longitudinal strain (GLS). RESULTS: Two thousand eight subjects were enrolled in 15 countries. The median age was 45 years (interquartile range, 32-65 years), 42.8% were white, 41.8% were Asian, and 9.7% were black. LV dimensions and volumes were larger in male subjects, while LVEF and GLS were higher in female subjects. Global WASE normal ranges for LV dimensions were smaller than those in the guidelines, but the upper limits of normal for LV volumes and the lower limits of normal for LVEF were higher in the WASE study. Significant intercountry variation was identified for all LV parameters reflecting LV size (dimensions, mass, and volumes) even after indexing to body surface area, with LV end-diastolic and end-systolic volumes having the highest variation. The largest volumes were noted in Australia, while the smallest were measured in India for both genders. This finding suggests that in addition to gender and body surface area, specific country should be considered when evaluating LV volumes. Intercountry variation for LVEF and GLS was smaller but still statistically significant (P < .05 for all). CONCLUSIONS: LV dimensions and volumes are larger in men, while LVEF and GLS are higher in women. Current guideline-recommended normal ranges for LV volumes and LVEF should be adjusted. Intercountry variability is significant for LV volumes, and therefore nationality should be considered for defining ranges of normality.
BACKGROUND: The World Alliance Societies of Echocardiography (WASE) Normal Values Study evaluates individuals from multiple countries and races with the aim of describing normative values that could be applied to the global community worldwide and to determine differences and similarities among people from different countries and races. The present report focuses specifically on two-dimensional (2D) left ventricular (LV) dimensions, volumes, and systolic function. METHODS: The WASE Normal Values Study is a multicenter international, observational, prospective, cross-sectional study of healthy adult individuals. Participants recruited in each country were evenly distributed among six predetermined subgroups according to age and gender. Comprehensive 2D transthoracic echocardiograms were acquired and analyzed following strict protocols based on recent American Society of Echocardiography and European Association of Cardiovascular Imaging guidelines. Analysis was performed at the WASE 2D core laboratory and included 2D LV dimensions, LV volumes, and LV ejection fraction (LVEF) by the biplane Simpson method and global longitudinal strain (GLS). RESULTS: Two thousand eight subjects were enrolled in 15 countries. The median age was 45 years (interquartile range, 32-65 years), 42.8% were white, 41.8% were Asian, and 9.7% were black. LV dimensions and volumes were larger in male subjects, while LVEF and GLS were higher in female subjects. Global WASE normal ranges for LV dimensions were smaller than those in the guidelines, but the upper limits of normal for LV volumes and the lower limits of normal for LVEF were higher in the WASE study. Significant intercountry variation was identified for all LV parameters reflecting LV size (dimensions, mass, and volumes) even after indexing to body surface area, with LV end-diastolic and end-systolic volumes having the highest variation. The largest volumes were noted in Australia, while the smallest were measured in India for both genders. This finding suggests that in addition to gender and body surface area, specific country should be considered when evaluating LV volumes. Intercountry variation for LVEF and GLS was smaller but still statistically significant (P < .05 for all). CONCLUSIONS: LV dimensions and volumes are larger in men, while LVEF and GLS are higher in women. Current guideline-recommended normal ranges for LV volumes and LVEF should be adjusted. Intercountry variability is significant for LV volumes, and therefore nationality should be considered for defining ranges of normality.
Authors: Enrico G Ferro; Shafika Abrahams-Gessel; Thiago Veiga Jardim; Ryan Wagner; F Xavier Gomez-Olive; Alisha N Wade; Ferande Peters; Stephen Tollman; Thomas A Gaziano Journal: Circ Cardiovasc Qual Outcomes Date: 2021-11-16
Authors: Marco Merlo; Marco Masè; Andrew Perry; Eluisa La Franca; Elena Deych; Laura Ajello; Diego Bellavia; Andrea Boscutti; Marco Gobbo; Giuseppe Romano; Davide Stolfo; John Gorcsan; Francesco Clemenza; Gianfranco Sinagra; Luigi Adamo Journal: Heart Date: 2021-09-07 Impact factor: 5.994
Authors: Tom Kai Ming Wang; Milind Y Desai; Patrick Collier; Richard A Grimm; Brian P Griffin; Zoran B Popović Journal: Cardiovasc Diagn Ther Date: 2020-12
Authors: William E Moody; Hani M Mahmoud-Elsayed; Jonathan Senior; Uzma Gul; Ayisha M Khan-Kheil; Sebastian Horne; Amitava Banerjee; William M Bradlow; Robert Huggett; Sandeep S Hothi; Muhammad Shahid; Richard P Steeds Journal: CJC Open Date: 2020-09-20