Ceren Kizmazoglu1, Hasan Emre Aydin2, Ismail Kaya2, Murat Atar3, Bugra Husemoglu4, Orhan Kalemci1, Gulden Sozer5, Hasan Havitcioglu4,6. 1. Department of Neurosurgery, Dokuz Eylul University School of Medicine, Izmir, Turkey. 2. Department of Neurosurgery, Kutahya Health Science University Evliya Celebi Training and Research Hospital, Kutahya, Turkey. 3. Department of Neurosurgery, Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey. 4. Department of Biomechanics, Dokuz Eylul University School of Medicine Health Science Institute, Izmir, Turkey. 5. Department of Pathology, Forensic Medicine Institution, Izmir, Turkey. 6. Department of Orthopedics and Traumatology, Dokuz Eylul University School of Medicine, Izmir, Turkey.
Abstract
OBJECTIVE: The aim of this study was to investigate the biomechanical differences between human dura mater and dura mater substitutes to optimize biomimetic materials. METHODS: Four groups were investigated. Group I used cranial dura mater (n=10), group II used Gore-Tex® Expanded Cardiovascular Patch (W.L. Gore & Associates Inc., Flagstaff, AZ, USA) (n=6), group III used Durepair® (Medtronic Inc., Goleta, CA, USA) (n=6), and group IV used Tutopatch® (Tutogen Medical GmbH, Neunkirchen am Brand, Germany) (n=6). We used an axial compression machine to measure maximum tensile strength. RESULTS: The mean tensile strengths were 7.01±0.77 MPa for group I, 22.03±0.60 MPa for group II, 19.59±0.65 MPa for group III, and 3.51±0.63 MPa for group IV. The materials in groups II and III were stronger than those in group I. However, the materials in group IV were weaker than those in group I. CONCLUSION: An important dura mater graft property is biomechanical similarity to cranial human dura mater. This biomechanical study contributed to the future development of artificial dura mater substitutes with biomechanical properties similar to those of human dura mater.
OBJECTIVE: The aim of this study was to investigate the biomechanical differences between human dura mater and dura mater substitutes to optimize biomimetic materials. METHODS: Four groups were investigated. Group I used cranial dura mater (n=10), group II used Gore-Tex® Expanded Cardiovascular Patch (W.L. Gore & Associates Inc., Flagstaff, AZ, USA) (n=6), group III used Durepair® (Medtronic Inc., Goleta, CA, USA) (n=6), and group IV used Tutopatch® (Tutogen Medical GmbH, Neunkirchen am Brand, Germany) (n=6). We used an axial compression machine to measure maximum tensile strength. RESULTS: The mean tensile strengths were 7.01±0.77 MPa for group I, 22.03±0.60 MPa for group II, 19.59±0.65 MPa for group III, and 3.51±0.63 MPa for group IV. The materials in groups II and III were stronger than those in group I. However, the materials in group IV were weaker than those in group I. CONCLUSION: An important dura mater graft property is biomechanical similarity to cranial human dura mater. This biomechanical study contributed to the future development of artificial dura mater substitutes with biomechanical properties similar to those of human dura mater.
Authors: Daniel Azzam; Prasanth Romiyo; Thien Nguyen; John P Sheppard; Yasmine Alkhalid; Carlito Lagman; Giyarpuram N Prashant; Isaac Yang Journal: World Neurosurg Date: 2018-01-31 Impact factor: 2.104
Authors: Vasilios A Zerris; Kenneth S James; Julie B Roberts; Eugene Bell; Carl B Heilman Journal: J Biomed Mater Res B Appl Biomater Date: 2007-11 Impact factor: 3.368