Literature DB >> 31676563

Androgen Receptor Interaction with Mediator Complex Is Enhanced in Castration-Resistant Prostate Cancer by CDK7 Phosphorylation of MED1.

Joshua W Russo1, Mannan Nouri1, Steven P Balk2.   

Abstract

In this issue of Cancer Discovery, Rasool and colleagues show that TF11H/CDK7 phosphorylates the MED1 component of the Mediator complex, which enhances its interaction with androgen receptor (AR), and that this phosphorylation is increased in prostate cancer that is resistant to castration and enzalutamide. A covalent CDK7-specific inhibitor (THZ1) impairs AR-mediated MED1 recruitment to chromatin, and can suppress enzalutamide resistance in vitro and induce tumor regression in a castration-resistant prostate cancer xenograft model, suggesting a novel therapeutic approach for advanced prostate cancer.See related article by Rasool et al., p. 1538. ©2019 American Association for Cancer Research.

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Year:  2019        PMID： 31676563      PMCID： PMC6830511          DOI： 10.1158/2159-8290.CD-19-1028

Source DB:  PubMed          Journal:  Cancer Discov        ISSN： 2159-8274            Impact factor:   39.397


  10 in total

1.  MED1 phosphorylation promotes its association with mediator: implications for nuclear receptor signaling.

Authors:  Madesh Belakavadi; Pradeep K Pandey; Ravi Vijayvargia; Joseph D Fondell
Journal:  Mol Cell Biol       Date:  2008-04-07       Impact factor: 4.272

2.  A Pliable Mediator Acts as a Functional Rather Than an Architectural Bridge between Promoters and Enhancers.

Authors:  Laila El Khattabi; Haiyan Zhao; Jens Kalchschmidt; Natalie Young; Seolkyoung Jung; Peter Van Blerkom; Philippe Kieffer-Kwon; Kyong-Rim Kieffer-Kwon; Solji Park; Xiang Wang; Jordan Krebs; Subhash Tripathi; Noboru Sakabe; Débora R Sobreira; Su-Chen Huang; Suhas S P Rao; Nathanael Pruett; Daniel Chauss; Erica Sadler; Andrea Lopez; Marcelo A Nóbrega; Erez Lieberman Aiden; Francisco J Asturias; Rafael Casellas
Journal:  Cell       Date:  2019-08-08       Impact factor: 41.582

3.  CDK7 Inhibition Suppresses Castration-Resistant Prostate Cancer through MED1 Inactivation.

Authors:  Reyaz Ur Rasool; Ramakrishnan Natesan; Qu Deng; Shweta Aras; Priti Lal; Samuel Sander Effron; Erick Mitchell-Velasquez; Jessica M Posimo; Shannon Carskadon; Sylvan C Baca; Mark M Pomerantz; Javed Siddiqui; Lauren E Schwartz; Daniel J Lee; Nallasivam Palanisamy; Goutham Narla; Robert B Den; Matthew L Freedman; Donita C Brady; Irfan A Asangani
Journal:  Cancer Discov       Date:  2019-08-29       Impact factor: 39.397

Review 4.  Targeting the androgen receptor and overcoming resistance in prostate cancer.

Authors:  David J Einstein; Seiji Arai; Steven P Balk
Journal:  Curr Opin Oncol       Date:  2019-05       Impact factor: 3.645

5.  Regulation of androgen receptor-dependent transcription by coactivator MED1 is mediated through a newly discovered noncanonical binding motif.

Authors:  Feng Jin; Frank Claessens; Joseph D Fondell
Journal:  J Biol Chem       Date:  2011-11-18       Impact factor: 5.157

6.  CDK9 regulates AR promoter selectivity and cell growth through serine 81 phosphorylation.

Authors:  Vicki Gordon; Shriti Bhadel; Winfried Wunderlich; JoAnn Zhang; Scott B Ficarro; Sahana A Mollah; Jeffrey Shabanowitz; Donald F Hunt; Ioannis Xenarios; William C Hahn; Mark Conaway; Michael F Carey; Daniel Gioeli
Journal:  Mol Endocrinol       Date:  2010-10-27

7.  Proteomic analysis of coregulators bound to ERα on DNA and nucleosomes reveals coregulator dynamics.

Authors:  Charles E Foulds; Qin Feng; Chen Ding; Suzanna Bailey; Tamra L Hunsaker; Anna Malovannaya; Ross A Hamilton; Leah A Gates; Zheng Zhang; Chunshu Li; Doug Chan; Amol Bajaj; Celetta G Callaway; Dean P Edwards; David M Lonard; Sophia Y Tsai; Ming-Jer Tsai; Jun Qin; Bert W O'Malley
Journal:  Mol Cell       Date:  2013-07-11       Impact factor: 17.970

8.  Specific structural motifs determine TRAP220 interactions with nuclear hormone receptors.

Authors:  Y Ren; E Behre; Z Ren; J Zhang; Q Wang; J D Fondell
Journal:  Mol Cell Biol       Date:  2000-08       Impact factor: 4.272

9.  The phosphorylation of the androgen receptor by TFIIH directs the ubiquitin/proteasome process.

Authors:  Pierre Chymkowitch; Nicolas Le May; Pierre Charneau; Emmanuel Compe; Jean-Marc Egly
Journal:  EMBO J       Date:  2010-12-14       Impact factor: 11.598

10.  Androgen Receptor Pathway-Independent Prostate Cancer Is Sustained through FGF Signaling.

Authors:  Eric G Bluemn; Ilsa M Coleman; Jared M Lucas; Roger T Coleman; Susana Hernandez-Lopez; Robin Tharakan; Daniella Bianchi-Frias; Ruth F Dumpit; Arja Kaipainen; Alexandra N Corella; Yu Chi Yang; Michael D Nyquist; Elahe Mostaghel; Andrew C Hsieh; Xiaotun Zhang; Eva Corey; Lisha G Brown; Holly M Nguyen; Kenneth Pienta; Michael Ittmann; Michael Schweizer; Lawrence D True; David Wise; Paul S Rennie; Robert L Vessella; Colm Morrissey; Peter S Nelson
Journal:  Cancer Cell       Date:  2017-10-09       Impact factor: 31.743
  10 in total
  7 in total

1.  TcoFBase: a comprehensive database for decoding the regulatory transcription co-factors in human and mouse.

Authors:  Yuexin Zhang; Chao Song; Yimeng Zhang; Yuezhu Wang; Chenchen Feng; Jiaxin Chen; Ling Wei; Qi Pan; Desi Shang; Yanbing Zhu; Jiang Zhu; Shuangsang Fang; Jun Zhao; Yongsan Yang; Xilong Zhao; Xiaozheng Xu; Qiuyu Wang; Jincheng Guo; Chunquan Li
Journal:  Nucleic Acids Res       Date:  2022-01-07       Impact factor: 16.971

2.  Epigenetic Coregulation of Androgen Receptor Signaling.

Authors:  Rayzel C Fernandes; Damien A Leach; Charlotte L Bevan
Journal:  Adv Exp Med Biol       Date:  2022       Impact factor: 3.650

3.  Identification of the Transcription Co-Factor-Related Gene Signature and Risk Score Model for Osteosarcoma.

Authors:  Zhijian Jin; Jintao Wu; Jianwei Lin; Jun Wang; Yuhui Shen
Journal:  Front Genet       Date:  2022-06-06       Impact factor: 4.772

Review 4.  Biomolecular Condensates and Cancer.

Authors:  Ann Boija; Isaac A Klein; Richard A Young
Journal:  Cancer Cell       Date:  2021-01-07       Impact factor: 31.743

Review 5.  Super-enhancer in prostate cancer: transcriptional disorders and therapeutic targets.

Authors:  Xuanrong Chen; Qianwang Ma; Zhiqun Shang; Yuanjie Niu
Journal:  NPJ Precis Oncol       Date:  2020-11-19

6.  Med1 controls CD8 T cell maintenance through IL-7R-mediated cell survival signalling.

Authors:  Lei Lei; Xiaofeng Yang; Yanhong Su; Huiqiang Zheng; Jun Liu; Haiyan Liu; Yujing Zou; Anjun Jiao; Xin Wang; Cangang Zhang; Xingzhe Zhang; Jiahui Zhang; Dan Zhang; Xiaobo Zhou; Lin Shi; Enqi Liu; Liang Bai; Chenming Sun; Baojun Zhang
Journal:  J Cell Mol Med       Date:  2021-03-17       Impact factor: 5.310

7.  Identification of Therapeutic Targets and Prognostic Biomarkers among Genes from the Mediator Complex Family in the Hepatocellular Carcinoma Tumour-Immune Microenvironment.

Authors:  Wei Tan; Shuai Peng; Zhuokai Li; Ruiqian Zhang; Yangrui Xiao; Xiao Chen; Jinde Zhu; Bingrong Li; Xinliang Lv
Journal:  Comput Math Methods Med       Date:  2022-01-13       Impact factor: 2.238
  7 in total

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