Literature DB >> 316755

The effect of irradiation on T-cell suppression of ELISA-determined Ig production by human blood B-cells in vitro.

J Wasserman, L V Von Stedingk, G Biberfeld, B Petrini, H Blomgren, E Baral.   

Abstract

Human blood B-lymphocytes were co-cultured with in vitro irradiated allogeneic or autologous T-lymphocytes in the presence of pokeweed mitogen (PWM). The production of IgG, IgM and IgA, as assessed by the enzyme-linked immunosorbent assay (ELISA) was increased 2--7 times, as compared to values obtained with non-irradiated T-lymphocytes. It is suggested that the increase of Ig production is due to the selective radiosensitivity of T-lymphocytes with suppressor function.

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Year:  1979        PMID： 316755      PMCID： PMC1537871     

Source DB:  PubMed          Journal:  Clin Exp Immunol        ISSN： 0009-9104            Impact factor:   4.330


  7 in total

1.  Subpopulations of human T lymphocytes. II. Effect of thymopoietin, corticosteroids, and irradiation.

Authors:  S Gupta; R A Good
Journal:  Cell Immunol       Date:  1977-11       Impact factor: 4.868

2.  Blood lymphocyte subpopulations in breast cancer patients following radiotherapy.

Authors:  B Petrini; J Wasserman; H Blomgren; E Baral
Journal:  Clin Exp Immunol       Date:  1977-07       Impact factor: 4.330

3.  Enzyme-linked immunosorbent assay, Elisa. 3. Quantitation of specific antibodies by enzyme-labeled anti-immunoglobulin in antigen-coated tubes.

Authors:  E Engvall; P Perlmann
Journal:  J Immunol       Date:  1972-07       Impact factor: 5.422

4.  Enhancement by irradiated T cells of human plasma cell production: dissection of helper and suppressor functions in vitro.

Authors:  F P Siegal; M Siegal
Journal:  J Immunol       Date:  1977-02       Impact factor: 5.422

5.  Thyroiditis in T cell-depleted rats. Influence of strain, radiation dose, adjuvants and antilymphocyte serum.

Authors:  W J Penhale; A Farmer; W J Irvine
Journal:  Clin Exp Immunol       Date:  1975-09       Impact factor: 4.330

6.  Response of human lymphocytes to mitogenic stimuli after irradiation in vitro.

Authors:  E Baral; H Blomgren
Journal:  Acta Radiol Ther Phys Biol       Date:  1976-04

7.  Functional analysis of two human T-cell subpopulations: help and suppression of B-cell responses by T cells bearing receptors for IgM or IgG.

Authors:  L Moretta; S R Webb; C E Grossi; P M Lydyard; M D Cooper
Journal:  J Exp Med       Date:  1977-07-01       Impact factor: 14.307
  7 in total
  11 in total

1.  Influence of alpha-interferon therapy on blood lymphoid cells. Studies on antibody production, mixed lymphocyte culture response, mitogen responsiveness and 2'-5'oligoadenylate synthetase activity.

Authors:  S Einhorn; P Ling; N Einhorn; H Strander; J Wasserman
Journal:  Cancer Immunol Immunother       Date:  1987       Impact factor: 6.968

2.  T8 cell suppression of antigen- and mitogen-induced T4 cell dependent immunoglobulin production.

Authors:  E Nilsson; L V von Stedingk; G Biberfeld
Journal:  Clin Exp Immunol       Date:  1986-10       Impact factor: 4.330

3.  PPD-induced viral antibody production in human blood lymphocytes.

Authors:  G Biberfeld; M Forsgren; L V Von Stedingk; P Arneborn
Journal:  Clin Exp Immunol       Date:  1980-11       Impact factor: 4.330

4.  Clinical evaluation of B cell and T-regulator cell function using a protein A haemolytic plaque assay.

Authors:  B M Jones
Journal:  Clin Exp Immunol       Date:  1981-10       Impact factor: 4.330

5.  Inhibition of suppressor T cells in pokeweed mitogen-stimulated cultures of T and B cells by levamisole in vitro and in vivo.

Authors:  P Hersey; K Ho; J Werkmeister; U Abele
Journal:  Clin Exp Immunol       Date:  1981-11       Impact factor: 4.330

6.  Single cell protein as an occupational hazard.

Authors:  L Ekenvall; B Dölling; C J Göthe; L Ebbinghaus; L V von Stedingk; J Wasserman
Journal:  Br J Ind Med       Date:  1983-05

7.  Regulation of human immunoglobulin production in vitro by prostaglandin E2.

Authors:  N D Staite; G S Panayi
Journal:  Clin Exp Immunol       Date:  1982-07       Impact factor: 4.330

8.  Specific and non-specific B cell activation in measles and varicella.

Authors:  P Arneborn; G Biberfeld; M Forsgren; L V von Stedingk
Journal:  Clin Exp Immunol       Date:  1983-01       Impact factor: 4.330

9.  Indomethacin inhibits in vitro immunoglobulin production by human B-lymphocytes.

Authors:  G S Panayi; N D Staite; A Unger
Journal:  Agents Actions       Date:  1981-12

Review 10.  Epstein-Barr virus (EBV)-specific cell-mediated and humoral immune responses in ataxia-telangectasia patients.

Authors:  G Masucci; I Berkel; M G Masucci; I Ernberg; R Szigeti; F Ersoy; O Sanal; O Yegin; G Henle; W Henle
Journal:  J Clin Immunol       Date:  1984-09       Impact factor: 8.317
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