| Literature DB >> 31672891 |
Michael J Mina1,2,3, Tomasz Kula4,2, Yumei Leng4, Mamie Li2, Rory D de Vries5, Mikael Knip6,7, Heli Siljander6,7, Marian Rewers8, David F Choy9, Mark S Wilson9, H Benjamin Larman10, Ashley N Nelson11, Diane E Griffin11, Rik L de Swart5, Stephen J Elledge1,2,12.
Abstract
Measles virus is directly responsible for more than 100,000 deaths yearly. Epidemiological studies have associated measles with increased morbidity and mortality for years after infection, but the reasons why are poorly understood. Measles virus infects immune cells, causing acute immune suppression. To identify and quantify long-term effects of measles on the immune system, we used VirScan, an assay that tracks antibodies to thousands of pathogen epitopes in blood. We studied 77 unvaccinated children before and 2 months after natural measles virus infection. Measles caused elimination of 11 to 73% of the antibody repertoire across individuals. Recovery of antibodies was detected after natural reexposure to pathogens. Notably, these immune system effects were not observed in infants vaccinated against MMR (measles, mumps, and rubella), but were confirmed in measles-infected macaques. The reduction in humoral immune memory after measles infection generates potential vulnerability to future infections, underscoring the need for widespread vaccination.Entities:
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Year: 2019 PMID： 31672891 DOI： 10.1126/science.aay6485
Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728