Literature DB >> 31663818

Exploiting phage strategies to modulate bacterial transcription.

Markus C Wahl1,2, Ranjan Sen3.   

Abstract

Bacteriophages employ small proteins to usurp host molecular machinery, thereby interfering with central metabolic processes in infected bacteria. Generally, phages inhibit or redirect host transcription to favor transcription of their own genomes. Mechanistic and structural studies of phage-modulated host transcription may provide inspirations for the development of novel antibacterial substances.

Entities:  

Keywords:  Antimicrobial peptides; bacteriophage antibacterial proteins; structural biology; transcription regulation in bacteria

Mesh：

Substances：

Year:  2019        PMID： 31663818      PMCID： PMC6948966          DOI： 10.1080/21541264.2019.1684137

Source DB:  PubMed          Journal:  Transcription        ISSN： 2154-1272


  64 in total

1.  The remarkable specificity of a new transcription termination factor suggests that the mechanisms of termination and antitermination are similar.

Authors:  J Robert; S B Sloan; R A Weisberg; M E Gottesman; R Robledo; D Harbrecht
Journal:  Cell       Date:  1987-11-06       Impact factor: 41.582

2.  RNA Polymerase Accommodates a Pause RNA Hairpin by Global Conformational Rearrangements that Prolong Pausing.

Authors:  Jin Young Kang; Tatiana V Mishanina; Michael J Bellecourt; Rachel Anne Mooney; Seth A Darst; Robert Landick
Journal:  Mol Cell       Date:  2018-03-01       Impact factor: 17.970

Review 3.  Transcriptional antitermination.

Authors:  J Greenblatt; J R Nodwell; S W Mason
Journal:  Nature       Date:  1993-07-29       Impact factor: 49.962

Review 4.  Regulation of Transcript Elongation.

Authors:  Georgiy A Belogurov; Irina Artsimovitch
Journal:  Annu Rev Microbiol       Date:  2015-06-24       Impact factor: 15.500

5.  Identification and validation of small molecule modulators of the NusB-NusE interaction.

Authors:  Peter J Cossar; Cong Ma; Christopher P Gordon; Joseph I Ambrus; Peter J Lewis; Adam McCluskey
Journal:  Bioorg Med Chem Lett       Date:  2016-12-01       Impact factor: 2.823

6.  The site of action of the antiterminator protein N from the lambdoid phage H-19B.

Authors:  Anoop Cheeran; Nanci R Kolli; Ranjan Sen
Journal:  J Biol Chem       Date:  2007-08-13       Impact factor: 5.157

7.  Structural basis for promoter specificity switching of RNA polymerase by a phage factor.

Authors:  Shunsuke Tagami; Shun-ichi Sekine; Leonid Minakhin; Daria Esyunina; Ryogo Akasaka; Mikako Shirouzu; Andrey Kulbachinskiy; Konstantin Severinov; Shigeyuki Yokoyama
Journal:  Genes Dev       Date:  2014-03-01       Impact factor: 11.361

Review 8.  Transcriptional control in the prereplicative phase of T4 development.

Authors:  Deborah M Hinton
Journal:  Virol J       Date:  2010-10-28       Impact factor: 4.099

9.  Antimicrobial peptides.

Authors:  Ali Adem Bahar; Dacheng Ren
Journal:  Pharmaceuticals (Basel)       Date:  2013-11-28

10.  A Thermus phage protein inhibits host RNA polymerase by preventing template DNA strand loading during open promoter complex formation.

Authors:  Wei-Yang Ooi; Yuko Murayama; Vladimir Mekler; Leonid Minakhin; Konstantin Severinov; Shigeyuki Yokoyama; Shun-Ichi Sekine
Journal:  Nucleic Acids Res       Date:  2018-01-09       Impact factor: 16.971
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  2 in total

Review 1.  The Context-Dependent Influence of Promoter Sequence Motifs on Transcription Initiation Kinetics and Regulation.

Authors:  Drake Jensen; Eric A Galburt
Journal:  J Bacteriol       Date:  2021-03-23       Impact factor: 3.490

2.  Transcription complexes as RNA chaperones.

Authors:  Nelly Said; Markus C Wahl
Journal:  Transcription       Date:  2021-11-01
  2 in total

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