| Literature DB >> 31663754 |
Álvaro Velasco-Rubio1, Eric J Alexy1, Makoto Yoritate1, Austin C Wright1, Brian M Stoltz1.
Abstract
A versatile thermal Overman rearrangement of enantioenriched, cyclic allylic alcohols providing tertiary allylic amines has been developed. The vinyl bromide used to control enantioselectivity in a preceding CBS reduction is utilized as a synthetic handle for the preparation of tertiary α-amino ketones and related derivatives in an asymmetric fashion.Entities:
Year: 2019 PMID： 31663754 DOI： 10.1021/acs.orglett.9b03347
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005