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Literature DB >> 3166361

No cytogenetic effects of quinolone treatment in humans.

F Mitelman¹, A M Kolnig, B Strömbeck, R Norrby, B Kromann-Andersen, P Sommer, J Wadstein.

Abstract

Cytogenetic effects of ciprofloxacin (500 to 2,000 mg daily) and ofloxacin (200 mg daily) were studied in lymphocytes from 31 patients treated for 1 to 10 weeks. Blood samples for cytogenetic analysis were taken before the start of treatment from all patients, after 1 week from 25 patients, and after 2, 4, 6, and 10 weeks from six patients. No chromosome-damaging effect could be demonstrated in any treatment group. The mean aberration yields for each cytogenetic parameter studied and the total number of aberrations were all normal at each sampling occasion.

Entities: Chemical Species

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Year: 1988 PMID： 3166361 PMCID： PMC172312 DOI： 10.1128/AAC.32.6.936

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

8 in total

1. A twin study of structural chromosome aberrations in lymphocytes.

Authors: K Hedner; A M Kolnig; B Strömbeck; A Nordén; F Mitelman
Journal: Cytogenet Cell Genet Date: 1986

2. Metronidazole exhibits no clastogenic activity in a double-blind cross-over study on Crohn's patients.

Authors: F Mitelman; B Strömbeck; B Ursing; O Nordle; B Hartley-Asp
Journal: Hereditas Date: 1982 Impact factor: 3.271

3. Chromosome aberrations and micronuclei in bone marrow cells and peripheral blood lymphocytes in humans exposed to ethylene oxide.

Authors: B Högstedt; B Gullberg; K Hedner; A M Kolnig; F Mitelman; S Skerfving; B Widegren
Journal: Hereditas Date: 1983 Impact factor: 3.271

4. Relationship between sister chromatid exchanges and structural chromosome aberrations in lymphocytes of 100 individuals.

Authors: K Hedner; B Högstedt; A M Kolnig; E Mark-Vendel; B Strömbeck; F Mitelman
Journal: Hereditas Date: 1982 Impact factor: 3.271

5. Mechanism of inhibition of DNA gyrase by analogues of nalidixic acid: the target of the drugs is DNA.

Authors: L L Shen; A G Pernet
Journal: Proc Natl Acad Sci U S A Date: 1985-01 Impact factor: 11.205

6. Effects of ciprofloxacin on eucaryotic pyrimidine nucleotide biosynthesis and cell growth.

Authors: A Forsgren; A Bredberg; A B Pardee; S F Schlossman; T F Tedder
Journal: Antimicrob Agents Chemother Date: 1987-05 Impact factor: 5.191

7. 4-Quinolone drugs affect cell cycle progression and function of human lymphocytes in vitro.

Authors: A Forsgren; S F Schlossman; T F Tedder
Journal: Antimicrob Agents Chemother Date: 1987-05 Impact factor: 5.191

8. Quinolones affect thymidine incorporation into the DNA of human lymphocytes.

Authors: A Forsgren; A K Bergh; M Brandt; G Hansson
Journal: Antimicrob Agents Chemother Date: 1986-03 Impact factor: 5.191

8 in total

7 in total

7. Characterization of Abcc4 gene amplification in stepwise-selected mouse J774 macrophages resistant to the topoisomerase II inhibitor ciprofloxacin.

Authors: Béatrice Marquez; Geneviève Ameye; Coralie M Vallet; Paul M Tulkens; Hélène A Poirel; Françoise Van Bambeke
Journal: PLoS One Date: 2011-12-05 Impact factor: 3.240

7 in total

No cytogenetic effects of quinolone treatment in humans.

1. A twin study of structural chromosome aberrations in lymphocytes.

2. Metronidazole exhibits no clastogenic activity in a double-blind cross-over study on Crohn's patients.

3. Chromosome aberrations and micronuclei in bone marrow cells and peripheral blood lymphocytes in humans exposed to ethylene oxide.

4. Relationship between sister chromatid exchanges and structural chromosome aberrations in lymphocytes of 100 individuals.

5. Mechanism of inhibition of DNA gyrase by analogues of nalidixic acid: the target of the drugs is DNA.

6. Effects of ciprofloxacin on eucaryotic pyrimidine nucleotide biosynthesis and cell growth.

7. 4-Quinolone drugs affect cell cycle progression and function of human lymphocytes in vitro.

8. Quinolones affect thymidine incorporation into the DNA of human lymphocytes.

Review 1. Quinolone antimicrobial agents: adverse effects and bacterial resistance.

Review 2. Inhibitory effects of quinolone antibacterial agents on eucaryotic topoisomerases and related test systems.

Review 3. Clinical features and management of adverse effects of quinolone antibacterials.

4. In vitro activity of AT-4140 against clinical bacterial isolates.

5. Activity of quinolones in the Ames Salmonella TA102 mutagenicity test and other bacterial genotoxicity assays.

Review 6. Mutagenicity of quinolone antibacterials.

7. Characterization of Abcc4 gene amplification in stepwise-selected mouse J774 macrophages resistant to the topoisomerase II inhibitor ciprofloxacin.