| Literature DB >> 31663301 |
L Franza1,2, V Carusi1,2, S Altamura1,2, Al Caraffa3, C E Gallenga4, S K Kritas5, G Ronconi6, P Conti7, F Pandolfi1,2.
Abstract
It is now well-known that interleukins (ILs) play a pivotal role in shaping innate immunity: inflammatory ILs are responsible for all innate aspects of immune response, from the very first vascular reactions to the chronic non-specific response to inflammation; while anti-inflammatory ILs are responsible for keeping adaptive immunity at bay. The interactions between ILs and adaptive immunity have been long considered secondary to the effects on the innate immune system, but in recent years it has appeared more clearly that IL direct interactions with adaptive immunity are extremely important both in physiologic and pathologic immune response. In the present review we analyze the role of inflammatory ILs (IL-1, IL-6, IL-33 and IL-37) on adaptive immunity and briefly discuss the possible therapeutic perspectives of IL-blockade in adaptive immunity disorders. Copyright 2019 Biolife Sas. www.biolifesas.org.Entities:
Keywords: IL-37; IL-6; inflammatory cytokines; innate immunity
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Year: 2019 PMID： 31663301 DOI： 10.23812/Editorial
Source DB: PubMed Journal: J Biol Regul Homeost Agents ISSN： 0393-974X Impact factor: 1.711