Riccardo Arisio1, Fulvio Borella2, Mauro Porpiglia2,3, Antonio Durando3,4, Roberto Bellino3,4, Maria Grazia Bau3,5, Corrado DE Sanctis3,5, Saverio Danese3,6, Chiara Benedetto2, Dionyssios Katsaros7,3. 1. Department of Surgical Sciences, Sant'Anna Hospital, Turin, Italy. 2. Gynecology and Obstetrics 1, Department of Surgical Sciences, University of Turin, Turin, Italy. 3. Breast Unit, Sant'Anna Hospital, Turin, Italy. 4. Gynecology and Obstetrics 2, Department of Surgical Sciences, University of Turin, Turin, Italy. 5. Gynecology and Obstetrics 3, Sant'Anna Hospital, Turin, Italy. 6. Gynecology and Obstetrics 4, Sant'Anna Hospital, Turin, Italy. 7. Gynecology and Obstetrics 1, Department of Surgical Sciences, University of Turin, Turin, Italy d.katsaros@libero.it.
Abstract
BACKGROUND/AIM: Axillary surgery of breast cancer patients is undergoing a paradigm shift, as axillary lymph node dissection's (ALND) usefulness is being questioned in the treatment of patients with tumor-positive sentinel lymph node biopsy (SLNB). The aim of this study was to investigate the overall survival (OS) and relapse-free survival (RFS) of patients with positive SLNB treated with ALND or not. PATIENTS AND METHODS: We investigated 617 consecutive patients with cN0 operable breast cancer with positive SLNB undergoing mastectomy or conservative surgery. A total of 406 patients underwent ALND and 211 were managed expectantly. RESULTS: No significant difference in OS and RFS was found between the two groups. The incidence of loco-regional recurrence in the SLNB-only group and the ALND group was low and not significant. CONCLUSION: The type of breast cancer surgery and the omission of ALND does not improve OS or RSF rate in cases with metastatic SLN. Copyright
BACKGROUND/AIM: Axillary surgery of breast cancerpatients is undergoing a paradigm shift, as axillary lymph node dissection's (ALND) usefulness is being questioned in the treatment of patients with tumor-positive sentinel lymph node biopsy (SLNB). The aim of this study was to investigate the overall survival (OS) and relapse-free survival (RFS) of patients with positive SLNB treated with ALND or not. PATIENTS AND METHODS: We investigated 617 consecutive patients with cN0 operable breast cancer with positive SLNB undergoing mastectomy or conservative surgery. A total of 406 patients underwent ALND and 211 were managed expectantly. RESULTS: No significant difference in OS and RFS was found between the two groups. The incidence of loco-regional recurrence in the SLNB-only group and the ALND group was low and not significant. CONCLUSION: The type of breast cancer surgery and the omission of ALND does not improve OS or RSF rate in cases with metastatic SLN. Copyright
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