Liling Zhu1,2, Kai Chen1,2, Lisa K Jacobs3, Rebecca Aft4. 1. Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China. 2. Breast Tumor Center, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China. 3. Departments of Surgery and Oncology, Johns Hopkins Medical Institutions, Baltimore, MD, USA. ljacob14@jhmi.edu. 4. Washington University, Siteman Cancer Center, St. Louis, MO, USA.