Literature DB >> 31662278

Mannogen-ing Central Carbon Metabolism by Leishmania.

Kai Zhang1, Stephen M Beverley2.   

Abstract

Leishmania parasites synthesize mannogens, a unique type of storage carbohydrate, from finely tuned interactions between synthesis and degradation by a family of mannosyltransferase/phosphorylases (MTPs) newly discovered by Sernee et al. The crucial roles of mannogen in regulating central carbon metabolism and in vivo virulence suggest the potential of MTPs as promising drug targets.
Copyright © 2019 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  dual-activity mannosyltransferase/phosphorylase; horizontal gene transfer; reservoir carbohydrate; trypanosomatid protozoan parasite; virulence

Mesh：

Substances：

Year:  2019        PMID： 31662278      PMCID： PMC8018590          DOI： 10.1016/j.pt.2019.10.001

Source DB:  PubMed          Journal:  Trends Parasitol        ISSN： 1471-4922


  8 in total

1.  Characterization of a Leishmania mexicana mutant defective in synthesis of free and protein-linked GPI glycolipids.

Authors:  Thomas Naderer; Malcolm J McConville
Journal:  Mol Biochem Parasitol       Date:  2002 Nov-Dec       Impact factor: 1.759

Review 2.  Lipophosphoglycan (LPG) and the identification of virulence genes in the protozoan parasite Leishmania.

Authors:  S M Beverley; S J Turco
Journal:  Trends Microbiol       Date:  1998-01       Impact factor: 17.079

3.  A Family of Dual-Activity Glycosyltransferase-Phosphorylases Mediates Mannogen Turnover and Virulence in Leishmania Parasites.

Authors:  M Fleur Sernee; Julie E Ralton; Tracy L Nero; Lukasz F Sobala; Joachim Kloehn; Marcel A Vieira-Lara; Simon A Cobbold; Lauren Stanton; Douglas E V Pires; Eric Hanssen; Alexandra Males; Tom Ward; Laurence M Bastidas; Phillip L van der Peet; Michael W Parker; David B Ascher; Spencer J Williams; Gideon J Davies; Malcolm J McConville
Journal:  Cell Host Microbe       Date:  2019-09-11       Impact factor: 21.023

4.  Leishmania beta-1,2-mannan is assembled on a mannose-cyclic phosphate primer.

Authors:  M Fleur Sernee; Julie E Ralton; Zoran Dinev; George N Khairallah; Richard A O'Hair; Spencer J Williams; Malcolm J McConville
Journal:  Proc Natl Acad Sci U S A       Date:  2006-06-09       Impact factor: 11.205

5.  Expression of a PTS2-truncated hexokinase produces glucose toxicity in Leishmania donovani.

Authors:  Ramesh Kumar; Suman Gupta; Rashmi Srivastava; Amogh A Sahasrabuddhe; Chhitar M Gupta
Journal:  Mol Biochem Parasitol       Date:  2009-11-27       Impact factor: 1.759

6.  Characterization and crystal structure determination of β-1,2-mannobiose phosphorylase from Listeria innocua.

Authors:  Tomohiro Tsuda; Takanori Nihira; Kazuhiro Chiku; Erika Suzuki; Takatoshi Arakawa; Mamoru Nishimoto; Motomitsu Kitaoka; Hiroyuki Nakai; Shinya Fushinobu
Journal:  FEBS Lett       Date:  2015-11-26       Impact factor: 4.124

7.  Evidence that intracellular beta1-2 mannan is a virulence factor in Leishmania parasites.

Authors:  Julie E Ralton; Thomas Naderer; Helena L Piraino; Tanya A Bashtannyk; Judy M Callaghan; Malcolm J McConville
Journal:  J Biol Chem       Date:  2003-08-05       Impact factor: 5.157

8.  Discovery of inhibitors of Leishmania β-1,2-mannosyltransferases using a click-chemistry-derived guanosine monophosphate library.

Authors:  Phillip van der Peet; Julie E Ralton; Malcolm J McConville; Spencer J Williams
Journal:  PLoS One       Date:  2012-02-29       Impact factor: 3.240
  8 in total
  1 in total

1.  Analysis of the diversity of the glycoside hydrolase family 130 in mammal gut microbiomes reveals a novel mannoside-phosphorylase function.

Authors:  Ao Li; Elisabeth Laville; Laurence Tarquis; Vincent Lombard; David Ropartz; Nicolas Terrapon; Bernard Henrissat; David Guieysse; Jeremy Esque; Julien Durand; Diego P Morgavi; Gabrielle Potocki-Veronese
Journal:  Microb Genom       Date:  2020-10
  1 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.