Literature DB >> 9481823

Lipophosphoglycan (LPG) and the identification of virulence genes in the protozoan parasite Leishmania.

S M Beverley1, S J Turco.   

Abstract

Leishmania exploits several strategies to survive within the phagolysosome of vertebrate macrophages and be transmitted by sand fly vectors. Recent advances in functional genetic analysis provide a new avenue for identifying genes implicated in the infectious cycle of the parasite, such as those necessary for the synthesis and expression of the key surface glycoconjugate, lipophosphoglycan (LPG).

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Year:  1998        PMID： 9481823     DOI： 10.1016/S0966-842X(97)01180-3

Source DB:  PubMed          Journal:  Trends Microbiol        ISSN： 0966-842X            Impact factor:   17.079


  62 in total

1.  Proteophosphoglycans of Leishmania mexicana. Molecular cloning and characterization of the Leishmania mexicana ppg2 gene encoding the proteophosphoglycans aPPG and pPPG2 that are secreted by amastigotes and promastigotes.

Authors:  U Göpfert; N Goehring; C Klein; T Ilg
Journal:  Biochem J       Date:  1999-12-15       Impact factor: 3.857

2.  Episomal expression of specific sense and antisense mRNAs in Leishmania amazonensis: modulation of gp63 level in promastigotes and their infection of macrophages in vitro.

Authors:  D Q Chen; B K Kolli; N Yadava; H G Lu; A Gilman-Sachs; D A Peterson; K P Chang
Journal:  Infect Immun       Date:  2000-01       Impact factor: 3.441

3.  AuBr(3) mediated glycosidations: synthesis of tetrasaccharide motif of the Leishmania donovani lipophosphoglycan.

Authors:  Gopalsamy Sureshkumar; Srinivas Hotha
Journal:  Glycoconj J       Date:  2012-06-03       Impact factor: 2.916

4.  Heterogeneity of wild Leishmania major isolates in experimental murine pathogenicity and specific immune response.

Authors:  C Kébaïer; H Louzir; M Chenik; A Ben Salah; K Dellagi
Journal:  Infect Immun       Date:  2001-08       Impact factor: 3.441

5.  Hydrophilic Acylated Surface Protein A (HASPA) of Leishmania donovani: Expression, Purification and Biophysico-Chemical Characterization.

Authors:  Manoj Kumar; Kishu Ranjan; Vijay Singh; Chandramani Pathak; Anju Pappachan; Desh Deepak Singh
Journal:  Protein J       Date:  2017-08       Impact factor: 2.371

Review 6.  Insight into a conserved lifestyle: protein-carbohydrate adhesion strategies of vector-borne pathogens.

Authors:  Rhoel R Dinglasan; Marcelo Jacobs-Lorena
Journal:  Infect Immun       Date:  2005-12       Impact factor: 3.441

7.  Coiling phagocytosis of trypanosomatids and fungal cells.

Authors:  M G Rittig; K Schröppel; K H Seack; U Sander; E N N'Diaye; I Maridonneau-Parini; W Solbach; C Bogdan
Journal:  Infect Immun       Date:  1998-09       Impact factor: 3.441

8.  The role(s) of lipophosphoglycan (LPG) in the establishment of Leishmania major infections in mammalian hosts.

Authors:  Gerald F Späth; L A Garraway; Salvatore J Turco; Stephen M Beverley
Journal:  Proc Natl Acad Sci U S A       Date:  2003-07-17       Impact factor: 11.205

9.  Characterization of a subunit of the outer dynein arm docking complex necessary for correct flagellar assembly in Leishmania donovani.

Authors:  Simone Harder; Meike Thiel; Joachim Clos; Iris Bruchhaus
Journal:  PLoS Negl Trop Dis       Date:  2010-01-26

10.  Leishmania major glycosylation mutants require phosphoglycans (lpg2-) but not lipophosphoglycan (lpg1-) for survival in permissive sand fly vectors.

Authors:  Anna Svárovská; Thomas H Ant; Veronika Seblová; Lucie Jecná; Stephen M Beverley; Petr Volf
Journal:  PLoS Negl Trop Dis       Date:  2010-01-12
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