Riikka J Gunnar1,2, Kaisa Kanerva3, Silja Salmi4, Taru Häyrinen5, Leena Haataja6, Mikko P Pakarinen2,7, Laura Merras-Salmio1,2. 1. Department of Pediatric Gastroenterology, New Children's Hospital, Helsinki University Hospital. 2. Pediatric Liver and Gut Research Group, Faculty of Medicine, Pediatric Research Center. 3. Department of Psychology and Logopedics. 4. Fammi Counseling and Psychological Services. 5. Department of Physiotherapy, New Children's Hospital, Helsinki University Hospital. 6. Department of Pediatric Neurology, New Children's Hospital, Pediatric Research Center, University of Helsinki and Helsinki University Hospital. 7. Department of Pediatric Surgery, New Helsinki University Children's Hospital, Helsinki, Finland.
Abstract
OBJECTIVE: The impact of pediatric intestinal failure (IF) on neurodevelopment beyond infancy has not been systematically studied. Our aim was to evaluate cognitive and motor impairment and to identify risk factors for adverse outcomes among children with IF. METHODS: We conducted a cross-sectional single-center study at the Helsinki University Children's Hospital. Patients with IF with >60 days of parental nutrition (PN) dependency aged between 3 and 16 years (n = 40) were invited to participate. The cognitive and motor skills were evaluated using validated tests: Wechsler Preschool and Primary Scale of Intelligence, 3rd edition, Wechsler Intelligence Scale for Children, 4th edition, and Movement Assessment Battery for Children, 2nd edition. RESULTS: All the patients attending the study tests (n = 30, males = 24) were included. Their median age, gestational age, and birth weight was 7.5 (range 3-16) years, 35 (interquartile range [IQR] 28-38) weeks and 2238 (IQR 1040-3288) grams, respectively. Median duration of PN was 13 (IQR 5-37) months and 9 patients were currently on PN. Median intelligence quotient was 78 (IQR 65-91) and 10 (35%) patients had an intelligence quotient under 70 (-2 standard deviation). Significant motor impairment was detected in 10 patients (36%) and milder difficulties in 8 (28%). Adverse cognitive outcome was associated with neonatal short bowel syndrome, number of interventions under general anesthesia, and length of inpatient status, whereas adverse motor outcome was associated with prematurity. CONCLUSION: Clinically significant cognitive and motor impairments are alarmingly common among neonatal patients with IF. We recommend early neurodevelopmental follow-up for all children with IF.
OBJECTIVE: The impact of pediatric intestinal failure (IF) on neurodevelopment beyond infancy has not been systematically studied. Our aim was to evaluate cognitive and motor impairment and to identify risk factors for adverse outcomes among children with IF. METHODS: We conducted a cross-sectional single-center study at the Helsinki University Children's Hospital. Patients with IF with >60 days of parental nutrition (PN) dependency aged between 3 and 16 years (n = 40) were invited to participate. The cognitive and motor skills were evaluated using validated tests: Wechsler Preschool and Primary Scale of Intelligence, 3rd edition, Wechsler Intelligence Scale for Children, 4th edition, and Movement Assessment Battery for Children, 2nd edition. RESULTS: All the patients attending the study tests (n = 30, males = 24) were included. Their median age, gestational age, and birth weight was 7.5 (range 3-16) years, 35 (interquartile range [IQR] 28-38) weeks and 2238 (IQR 1040-3288) grams, respectively. Median duration of PN was 13 (IQR 5-37) months and 9 patients were currently on PN. Median intelligence quotient was 78 (IQR 65-91) and 10 (35%) patients had an intelligence quotient under 70 (-2 standard deviation). Significant motor impairment was detected in 10 patients (36%) and milder difficulties in 8 (28%). Adverse cognitive outcome was associated with neonatal short bowel syndrome, number of interventions under general anesthesia, and length of inpatient status, whereas adverse motor outcome was associated with prematurity. CONCLUSION: Clinically significant cognitive and motor impairments are alarmingly common among neonatal patients with IF. We recommend early neurodevelopmental follow-up for all children with IF.
Authors: Lotte E Vlug; Merel W Verloop; Bram Dierckx; Lotte Bosman; Jurgen C de Graaff; Edmond H H M Rings; René M H Wijnen; Barbara A E de Koning; Jeroen S Legerstee Journal: J Pediatr Gastroenterol Nutr Date: 2022-03-01 Impact factor: 3.288
Authors: Sjoerd C J Nagelkerke; Hedy A van Oers; Lotte Haverman; Lotte E Vlug; Barbara A E de Koning; Marc A Benninga; Merit M Tabbers Journal: J Pediatr Gastroenterol Nutr Date: 2022-01-01 Impact factor: 3.288