Mehmet Fatih Küçük1, Ayşe Ayan2, Devrim Toslak3, Elçin Süren3, Lütfiye Yaprak3, Ersan Çetinkaya3, Muhammet Kazım Erol3, Deniz Turgut Çoban3. 1. Department of Ophthalmology, Faculty of Medicine, Alanya Alaaddin Keykubat University, Temel Tıp Bilimleri Binası Kestel Kampüsü Alanya, 07070, Antalya, Turkey. mehmet.kucuk@alanya.edu.tr. 2. Department of Rheumatology, Health Sciences University Antalya Training and Research Hospital, Antalya, Turkey. 3. Department of Ophthalmology, Health Sciences University Antalya Training and Research Hospital, Antalya, Turkey.
Abstract
AIMS: Determining whether nailfold capillary involvement is present in patients with Age-related macular degeneration (AMD) and whether there are different nailfold capillaroscopy findings between wet and dry types. METHODS: From January 2016 to December 2017, with an initial diagnosis of AMD, 53 consecutive adult patients (AMD group) and 91 age- and sex-matched healthy individuals were studied prospectively. There was no history of any other ocular disease and other disease affecting nailfold capillaries. All subjects underwent a complete ophthalmic examination. The classified and advanced stages of wet and dry types were not included. All nailfold capillaroscopy examinations were performed by the same rheumatologist. RESULTS: It was found that the frequency of major capillaroscopic findings such as capillary ectasia, micro-hemorrhage, tortuosity, neo-formation, bizarre capillary, and bushy capillaries increased in the AMD group according to the normal group, but no significant relationship was found for capillary aneurysm. In dry or wet type of AMD in terms of ectasia, micro-hemorrhage, tortuosity, neo-formation, bizarre structure, bushy structure, or aneurism of nailfold capillaries, no significant correlation was found. CONCLUSIONS: Nailfold capillaroscopy can detect microvascular changes in the nailfold capillary, in early and late stages of AMD. There were morphological changes in the nailfold capillaries of AMD patients, suggesting that there are systemic superficial microvascular changes that may be due to the systemic nature of the disease.
AIMS: Determining whether nailfold capillary involvement is present in patients with Age-related macular degeneration (AMD) and whether there are different nailfold capillaroscopy findings between wet and dry types. METHODS: From January 2016 to December 2017, with an initial diagnosis of AMD, 53 consecutive adult patients (AMD group) and 91 age- and sex-matched healthy individuals were studied prospectively. There was no history of any other ocular disease and other disease affecting nailfold capillaries. All subjects underwent a complete ophthalmic examination. The classified and advanced stages of wet and dry types were not included. All nailfold capillaroscopy examinations were performed by the same rheumatologist. RESULTS: It was found that the frequency of major capillaroscopic findings such as capillary ectasia, micro-hemorrhage, tortuosity, neo-formation, bizarre capillary, and bushy capillaries increased in the AMD group according to the normal group, but no significant relationship was found for capillary aneurysm. In dry or wet type of AMD in terms of ectasia, micro-hemorrhage, tortuosity, neo-formation, bizarre structure, bushy structure, or aneurism of nailfold capillaries, no significant correlation was found. CONCLUSIONS: Nailfold capillaroscopy can detect microvascular changes in the nailfold capillary, in early and late stages of AMD. There were morphological changes in the nailfold capillaries of AMD patients, suggesting that there are systemic superficial microvascular changes that may be due to the systemic nature of the disease.
Authors: Jan M Provis; Philip L Penfold; Elisa E Cornish; Trent M Sandercoe; Michele C Madigan Journal: Clin Exp Optom Date: 2005-09 Impact factor: 2.742
Authors: Yogesan Kanagasingam; Alauddin Bhuiyan; Michael D Abràmoff; R Theodore Smith; Leonard Goldschmidt; Tien Y Wong Journal: Prog Retin Eye Res Date: 2013-11-07 Impact factor: 21.198