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Literature DB >> 31642082

More or less - the same? mRNA fluctuations are balanced during translation.

Abstract

Transcription factors have been traditionally studied at the level of transcription, neglecting a potential impact on protein translation. A new study published by Lorent et al (2019) describes a mechanism by which fluctuations in mRNA abundance are counteracted during translation upon estrogen receptor-alpha (ERα) depletion. This phenomenon, termed translational offsetting, is prevalent and programmed to maintain essential proteins at constant levels.

Entities: Gene

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Year: 2019 PMID： 31642082 PMCID： PMC6885732 DOI： 10.15252/embj.2019103651

Source DB: PubMed Journal: EMBO J ISSN： 0261-4189 Impact factor: 11.598

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References

11 in total

1. Translational offsetting as a mode of estrogen receptor α-dependent regulation of gene expression.

Authors: Julie Lorent; Eric P Kusnadi; Vincent van Hoef; Richard J Rebello; Matthew Leibovitch; Johannes Ristau; Shan Chen; Mitchell G Lawrence; Krzysztof J Szkop; Baila Samreen; Preetika Balanathan; Francesca Rapino; Pierre Close; Patricia Bukczynska; Karin Scharmann; Itsuhiro Takizawa; Gail P Risbridger; Luke A Selth; Sebastian A Leidel; Qishan Lin; Ivan Topisirovic; Ola Larsson; Luc Furic
Journal: EMBO J Date: 2019-09-26 Impact factor: 11.598

2. N(6)-methyladenosine Modulates Messenger RNA Translation Efficiency.

Authors: Xiao Wang; Boxuan Simen Zhao; Ian A Roundtree; Zhike Lu; Dali Han; Honghui Ma; Xiaocheng Weng; Kai Chen; Hailing Shi; Chuan He
Journal: Cell Date: 2015-06-04 Impact factor: 41.582

Review 3. Alternative mRNA transcription, processing, and translation: insights from RNA sequencing.

Authors: Eleonora de Klerk; Peter A C 't Hoen
Journal: Trends Genet Date: 2015-01-30 Impact factor: 11.639

Review 4. Regulation of mRNA translation by signaling pathways.

Authors: Philippe P Roux; Ivan Topisirovic
Journal: Cold Spring Harb Perspect Biol Date: 2012-11-01 Impact factor: 10.005

Review 5. On the Dependency of Cellular Protein Levels on mRNA Abundance.

Authors: Yansheng Liu; Andreas Beyer; Ruedi Aebersold
Journal: Cell Date: 2016-04-21 Impact factor: 41.582

6. Tumour-specific proline vulnerability uncovered by differential ribosome codon reading.

Authors: Fabricio Loayza-Puch; Koos Rooijers; Levi C M Buil; Jelle Zijlstra; Joachim F Oude Vrielink; Rui Lopes; Alejandro Pineiro Ugalde; Pieter van Breugel; Ingrid Hofland; Jelle Wesseling; Olaf van Tellingen; Axel Bex; Reuven Agami
Journal: Nature Date: 2016-02-15 Impact factor: 49.962

More or less - the same? mRNA fluctuations are balanced during translation.

1. Translational offsetting as a mode of estrogen receptor α-dependent regulation of gene expression.

2. N(6)-methyladenosine Modulates Messenger RNA Translation Efficiency.

Review 3. Alternative mRNA transcription, processing, and translation: insights from RNA sequencing.

Review 4. Regulation of mRNA translation by signaling pathways.

Review 5. On the Dependency of Cellular Protein Levels on mRNA Abundance.

6. Tumour-specific proline vulnerability uncovered by differential ribosome codon reading.

7. Translation efficiency is determined by both codon bias and folding energy.

Review 8. Next-generation analysis of gene expression regulation--comparing the roles of synthesis and degradation.

9. Optimization of Codon Translation Rates via tRNA Modifications Maintains Proteome Integrity.

10. Transcription Impacts the Efficiency of mRNA Translation via Co-transcriptional N6-adenosine Methylation.